Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota DOI Creative Commons
Jing Li, Y. Xu, Tianhao Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Nephrotic syndrome (NS) represents a prevalent among various chronic kidney disease pathologies and is known for its higher severity worse prognosis compared with glomerulonephritis. Understanding pathogenesis identifying more effective treatment modalities have long been concern of specialists. With the introduction gut-kidney axis concept progress in omics technologies, alterations gut microbiota observed primary secondary NS. This link has extensively researched conditions such as diabetic nephropathy immunoglobulin A (IgA) nephropathy. Thus, dysbiosis seen crucial contributing factor NS; however, there lack comprehensive reviews that elucidate changes across different NS describe mechanistic role disease. Moreover, serving an innate regulator microbiota, traditional Chinese medicine (TCM) potential to exert profound impact on expression inflammation-promoting agents, decreasing levels endotoxins uremic toxins. In addition, it strengthens stability intestinal barrier while controlling metabolic function body through efficient modulation microbiota. intricate process yields far-reaching consequences

Language: Английский

The causal association between cardiovascular proteins and diabetic nephropathy: a Mendelian randomization study DOI
Fengyun Wang, Qiqi Ma

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Language: Английский

Citations

0
No Genetic Causality between Branched-Chain Amino Acids and Diabetic Nephropathy: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Qiqi Ma,

Shuaihua Song,

Gaosi Xu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 25, 2024

Abstract Background Numerous studies have reported the close relationship between branched-chain amino acids (BCAA) and diabetic nephropathy (DN). Nevertheless, whether there is a genetically causal association them remains profoundly elusive. Methods A two-sample Mendelian randomization (MR) analysis was performed using large genome-wide of European population. The primarily evaluated by inverse variance weighted (IVW) method. In addition, MR-Egger regression, median, simple mode, MR-weighted mode were also conducted as supplemented methods. For sensitivity, Cochrane’s Q test, MR-PRESSO employed to evaluate heterogeneity pleiotropy, respectively. Results According IVW method, no significant effect measured three BCAA DN (valine: OR: 1.202, 95% CI: 0.714–2.023, P = 0.488; isoleucine: 0.878, 0.400–1.924, 0.744; leucine: 1.395, 0.686–2.839, 0.358; total BCAA: 1.374, 0.703–2.685, 0.352). reverse MR analysis, an exposure factor had on 1.004, 0.994–1.014, 0.412; 0.999, 0.990–1.009, 0.910; 1.001, 0.992–1.011, 0.802; 1.002, 0.993–1.012, 0.628). Conclusion Our results first demonstrated at genetic level.

Language: Английский

Citations

0
Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota DOI Creative Commons
Jing Li, Y. Xu, Tianhao Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Nephrotic syndrome (NS) represents a prevalent among various chronic kidney disease pathologies and is known for its higher severity worse prognosis compared with glomerulonephritis. Understanding pathogenesis identifying more effective treatment modalities have long been concern of specialists. With the introduction gut-kidney axis concept progress in omics technologies, alterations gut microbiota observed primary secondary NS. This link has extensively researched conditions such as diabetic nephropathy immunoglobulin A (IgA) nephropathy. Thus, dysbiosis seen crucial contributing factor NS; however, there lack comprehensive reviews that elucidate changes across different NS describe mechanistic role disease. Moreover, serving an innate regulator microbiota, traditional Chinese medicine (TCM) potential to exert profound impact on expression inflammation-promoting agents, decreasing levels endotoxins uremic toxins. In addition, it strengthens stability intestinal barrier while controlling metabolic function body through efficient modulation microbiota. intricate process yields far-reaching consequences

Language: Английский

Citations

0