Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Янв. 9, 2023

Abstract The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis the process generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, transformation. mTORC1, Myc, noncoding RNA signaling pathways are primary mediators work jointly with polymerases proteins to control protein synthesis. Activation of mTORC1 required for normal fetal growth development tissue regeneration after birth. Myc implicated cancer by enhancing Pol II activity, leading uncontrolled growth. deregulation RNAs such as microRNAs, long RNAs, circular involved developing blood, neurodegenerative diseases, atherosclerosis. We review similarities differences between eukaryotic bacterial molecular mechanism ribosome-targeting antibiotics resistance. also most recent findings dysfunction COVID-19 other conditions discuss consequences frameshifting, ribosome-stalling, ribosome-collision. summarize various diseases. Furthermore, we current clinical trials, prospective vaccines COVID-19, therapies targeting cancer, cardiovascular disease, aging, disease.

Язык: Английский

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Photocatalytic degradation of sulfamethoxazole using TiO2-based materials – Perspectives for the development of a sustainable water treatment technology

The Science of The Total Environment, Год журнала: 2022, Номер 856, С. 159122 - 159122

Опубликована: Сен. 29, 2022

Язык: Английский

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Emerging groundwater contaminants: A comprehensive review on their health hazards and remediation technologies

Groundwater for Sustainable Development, Год журнала: 2022, Номер 20, С. 100868 - 100868

Опубликована: Ноя. 2, 2022

Язык: Английский

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Pharmaceutical waste-water treatment via advanced oxidation based integrated processes: An engineering and economic perspective

Journal of Water Process Engineering, Год журнала: 2023, Номер 54, С. 103977 - 103977

Опубликована: Июнь 28, 2023

Язык: Английский

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Usage of antibiotics in aquaculture and the impact on coastal waters

Marine Pollution Bulletin, Год журнала: 2023, Номер 188, С. 114645 - 114645

Опубликована: Янв. 30, 2023

Язык: Английский

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A cryptic plasmid is among the most numerous genetic elements in the human gut

Cell, Год журнала: 2024, Номер 187(5), С. 1206 - 1222.e16

Опубликована: Фев. 1, 2024

Plasmids are extrachromosomal genetic elements that often encode fitness-enhancing features. However, many bacteria carry "cryptic" plasmids do not confer clear beneficial functions. We identified one such cryptic plasmid, pBI143, which is ubiquitous across industrialized gut microbiomes and 14 times as numerous crAssphage, currently established the most abundant element in human gut. The majority of mutations pBI143 accumulate specific positions thousands metagenomes, indicating strong purifying selection. monoclonal individuals, likely due to priority effect version first acquired, from one's mother. can transfer between Bacteroidales, although it does appear impact bacterial host fitness vivo, transiently acquire additional content. important practical applications including its use identifying fecal contamination potential an alternative approach track colonic inflammatory states.

Язык: Английский

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Molecular imprinting technology for next-generation water treatment via photocatalysis and selective pollutant adsorption

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(3), С. 112768 - 112768

Опубликована: Апрель 10, 2024

Язык: Английский

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Metagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens

The Science of The Total Environment, Год журнала: 2025, Номер 961, С. 178403 - 178403

Опубликована: Янв. 1, 2025

Antimicrobial resistance (AMR) is a global health challenge, with hospitals and wastewater treatment plants (WWTPs) serving as significant pathways for the dissemination of antibiotic genes (ARGs). This study investigates potential wastewater-based epidemiology (WBE) an early warning system assessing burden AMR at population level. In this comprehensive year-long study, effluent was collected weekly from three large hospitals, treated untreated were monthly associated community WWTPs. Metagenomic analysis revealed significantly higher relative abundance diversity ARGs in hospital than Notably, conferring to clinically antibiotics such β-lactams, aminoglycosides, sulfonamides, tetracyclines more prevalent effluents. Conversely, rifampicin MLS (macrolides-lincosamide-streptogramin) commonly detected WWTPs, particularly effluent. Network identified bacterial hosts, which are key carriers these ARGs. The further highlighted variability ARG removal efficiencies across none achieving complete elimination or reduction diversity. Additionally, profiles remained relatively consistent throughout indicating persistent release baseload pathogenic bacteria into surface waters, potentially polluting aquatic environments entering food chain. underscores need routine WBE surveillance, enhanced strategies, hospital-level source control measures mitigate environment.

Язык: Английский

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Antibiotic contamination in wastewater treatment plant effluents: Current research and future perspectives

Environmental Nanotechnology Monitoring & Management, Год журнала: 2025, Номер unknown, С. 101047 - 101047

Опубликована: Янв. 1, 2025

Язык: Английский

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A review on plasmonic-based heterojunction photocatalysts for degradation of organic pollutants in wastewater

Journal of Materials Science, Год журнала: 2023, Номер 58(15), С. 6474 - 6515

Опубликована: Март 25, 2023

Язык: Английский

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