Accumulated melanin in molds provides wavelength-dependent UV tolerance DOI Creative Commons

Yushi Onoda,

Miharu Nagahashi,

Michiyo Yamashita

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

Novel Nitric Oxide Donor–Azole Conjugation Strategy for Efficient Treatment of Cryptococcus neoformans Infections DOI
Fangfang Wang, Jianbing Wu,

Mingke Yuan

и другие.

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(20), С. 14221 - 14240

Опубликована: Окт. 11, 2023

Invasive fungal infections (IFIs) such as cryptococcal meningitis (CM) remain a serious health issue worldwide due to drug resistance closely related biofilm formation. Unfortunately, available antifungal drugs with ideal safety and promising potency are still lacking; thus, the research of new candidate therapeutic approach is urgently needed. As an important gas messenger molecule, nitric oxide (NO) shows vital inhibition on various microorganism biofilms. Hence, three series novel NO-donating azole derivatives were designed synthesized, in vitro activity well mechanism action was investigated. Among them, 3a 3e displayed excellent against Cryptococcus neoformans depending release NO. Moreover, more stable analogue 3h demonstrated markedly anti-CM effects via intranasal dropping, avoiding first-pass possessing better brain permeability bypass blood-brain barrier. These results present dropping for treatment CM, warranting further studies.

Язык: Английский

Процитировано

5
Mechanism Underlying Light Intensity-Induced Melanin Synthesis of Auricularia heimuer Revealed by Transcriptome Analysis DOI Creative Commons
Zhiheng Qiu,

Yanliang Gao,

Shuang Wang

и другие.

Cells, Год журнала: 2022, Номер 12(1), С. 56 - 56

Опубликована: Дек. 23, 2022

is a traditional edible and medicinal mushroom, which widely used in biochemical research regarded as good dietary supplement. The color of the ear-like fruiting body an important indicator its commercial quality. However, mechanism by light intensity influences melanin synthesis

Язык: Английский

Процитировано

8
Hepatoprotective Effect of Annulohypoxylon stygium Melanin on Acute Alcoholic Liver Injury in Mice DOI
Ruofan Liu,

Cuiyuan Mo,

Xuetuan Wei

и другие.

Applied Biochemistry and Biotechnology, Год журнала: 2024, Номер 196(9), С. 6395 - 6408

Опубликована: Фев. 21, 2024

Язык: Английский

Процитировано

1
Uncovering the Mechanisms: The Role of Biotrophic Fungi in Activating or Suppressing Plant Defense Responses DOI Creative Commons
Michel Leiva-Mora, Yanelis Capdesuñer, Ariel Villalobos-Olivera

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 635 - 635

Опубликована: Сен. 5, 2024

This paper discusses the mechanisms by which fungi manipulate plant physiology and suppress defense responses producing effectors that can target various host proteins. Effector-triggered immunity effector-triggered susceptibility are pivotal elements in complex molecular dialogue underlying plant-pathogen interactions. Pathogen-produced effector molecules possess ability to mimic pathogen-associated patterns or hinder binding of pattern recognition receptors. Effectors directly nucleotide-binding domain, leucine-rich repeat receptors, downstream signaling components defense. Interactions between these receptor-like kinases plants critical this process. Biotrophic adeptly exploit networks key hormones, including salicylic acid, jasmonic abscisic ethylene, establish a compatible interaction with their hosts. Overall, highlights importance understanding interplay fungal develop effective strategies for disease management.

Язык: Английский

Процитировано

1
Accumulated melanin in molds provides wavelength-dependent UV tolerance DOI Creative Commons

Yushi Onoda,

Miharu Nagahashi,

Michiyo Yamashita

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

1