Natural Product Communications,
Год журнала:
2024,
Номер
19(2)
Опубликована: Фев. 1, 2024
Cadmium
(Cd),
a
highly
toxic
heavy
metal,
accumulates
in
the
liver
and
kidneys
human
body
by
several
routes.
Tomatoes
related
processed
food
possess
multiple
physiological
functions
such
as
antioxidation,
antiinflammation,
anticancer.
Herein,
to
investigate
whether
tomato
extract
(TE)
can
protect
against
cadmium
chloride
(CdCl
2
)-induced
oxidative
damage
kidneys,
models
were
established
vitro
vivo,
control
group
TE
intervention
groups
also
set
up.
A
significant
elevation
was
observed
Cd
concentration
level
of
alanine
transaminase
(ALT),
aspartate
aminotransferase
(AST),
blood
urea
nitrogen
(BUN),
creatinine
(CR),
uric
acid
(UA)
serum
CdCl
-treated
rats
compared
with
group,
contrast,
these
values
reduced
following
intervention.
Moreover,
it
found
that
exposure
decreased
superoxide
dismutase
(SOD)
activity,
glutathione
(GSH)
level,
catalase
(CAT)
activity
raised
malondialdehyde
(MDA)
serum,
tissues,
kidney
HepG2
cells,
which
be
reversed
mitigate
damage.
In
addition,
exerted
an
inhibitory
effect
on
cell
apoptosis
both
brought
intoxication,
manifested
downregulation
Caspase-3
protein
up-regulation
B-cell
lymphoma
gene
(Bcl-2)
after
treatment.
Altogether,
our
study
reinforces
previous
findings
disrupted
redox
homeostasis,
leading
kidneys.
More
importantly,
suggest
hepatorenal
protective
toxicity
is
implicated
inhibition
stress
apoptosis.
Nanomaterials,
Год журнала:
2023,
Номер
13(21), С. 2887 - 2887
Опубликована: Окт. 31, 2023
Timely
diagnosis
and
appropriate
antitumoral
treatments
remain
of
utmost
importance,
since
cancer
remains
a
leading
cause
death
worldwide.
Within
this
context,
nanotechnology
offers
specific
benefits
in
terms
therapy
by
reducing
its
adverse
effects
guiding
drugs
to
selectively
target
cells.
In
comprehensive
review,
we
have
summarized
the
most
relevant
novel
outcomes
range
2010-2023,
covering
design
application
nanosystems
for
therapy.
We
established
general
requirements
nanoparticles
be
used
drug
delivery
strategies
their
uptake
tumor
microenvironment
vasculature,
including
reticuloendothelial
system
surface
functionalization
with
protein
corona.
After
brief
review
classes
nanovectors,
covered
different
therapies.
First,
advances
encapsulation
(such
as
paclitaxel
fisetin)
into
nanoliposomes
nanoemulsions
are
described,
well
relevance
current
clinical
trials.
Then,
polymeric
presented,
namely
ones
comprising
poly
lactic-co-glycolic
acid,
polyethylene
glycol
(and
PEG
dilemma)
dendrimers.
The
quantum
dots
bioimaging
is
also
covered,
systems
zinc
sulfide
indium
phosphide.
Afterwards,
reviewed
gold
(spheres
anisotropic)
plasmon-induced
photothermal
iron
oxide
nanoparticles,
such
magnetite
maghemite,
has
been
analyzed
fields,
magnetic
resonance
imaging,
immunotherapy,
hyperthermia,
delivery.
Lastly,
recent
using
carbon
nanomaterials,
graphene
oxide,
nanotubes,
fullerenes,
dots.
Finally,
compared
passive
active
targeting
theranostics.
This
aims
(nano)mark
on
ongoing
journey
towards
realizing
remarkable
potential
realm
therapeutics.
ACS Omega,
Год журнала:
2023,
Номер
8(21), С. 18940 - 18950
Опубликована: Май 15, 2023
Heavy
metal
contamination
in
soil,
such
as
cadmium
(Cd),
poses
a
serious
threat
to
global
food
security
and
human
health.
It
must
be
managed
using
environmentally
friendly
cost-effective
technologies.
Plants
with
high
resistance
Cd
stress
biomass
production
could
potential
candidates
for
the
phytoremediation
of
Cd-contaminated
soils
improve
phytoextraction.
In
this
regard,
present
study
was
carried
out
determine
effect
gibberellic
acid
(GA3),
indole
acetic
(IAA),
fertilizers
(N,
P,
K)
on
Parthenium
hysterophorus
growth
well
phytoextraction
capabilities.
A
pot
experiment
conducted
various
combinations
PGRs
fertilizers,
treatments
arranged
five
replicates
completely
randomized
design.
After
harvesting,
each
plant
divided
into
parts
stems,
roots,
leaves,
different
growth,
physiological,
biochemical
parameters
were
recorded.
Results
showed
that
under
stress,
all
significantly
decreased.
With
combined
application
regulators
(GA3
IAA)
nutrients,
alleviated
improved.
comparison
control
treatment,
N
+
P
K
GA3
IAA
resulted
highest
fresh
dry
root
(12.31
5.11
g
pot-1),
shoot
(19.
69
6.99
leaves
(16.56
7.09
entire
(48.56
19.19
pot-1).
Similarly,
same
treatment
higher
chlorophyll
b
total
contents
which
2.19,
2.03,
3.21
times
than
control,
without
any
treatment.
The
combination
also
proline
phenolic
contents.
case
enzyme
activities,
led
increase
catalase
(2.5
times),
superoxide
(3.5
peroxidase
(3.7
times)
compared
control.
N+
P+
IAA,
maximum
values
BCF
(8.25),
BAC
(2.6),
RF
(5.14%)
measured
potential.
On
basis
these
findings,
it
is
concluded
P.
has
grow,
produce
most
biomass,
act
hyperaccumulator
soil.
Frontiers in Toxicology,
Год журнала:
2022,
Номер
4
Опубликована: Июль 6, 2022
Reactive
oxygen
species
(ROS)
and
reactive
nitrogen
(RNS)
are
formed
as
a
result
of
natural
cellular
processes,
intracellular
signaling,
or
adverse
responses
associated
with
diseases
exposure
to
oxidizing
chemical
non-chemical
stressors.
The
action
ROS
RNS,
collectively
referred
(RONS),
has
recently
become
highly
relevant
in
number
outcome
pathways
(AOPs)
that
capture,
organize,
evaluate
portray
causal
relationships
pertinent
adversity
disease
progression.
RONS
can
potentially
act
key
event
(KE)
the
cascade
leading
an
(AO)
within
such
AOPs,
but
also
known
modulate
events
along
AOP
continuum
without
being
itself.
A
substantial
discussion
therefore
been
undertaken
series
workshops
named
“Mystery
ROS”
elucidate
role
effects
stressors
nanoparticles,
chemical,
ionizing
non-ionizing
radiation.
This
review
introduces
background
for
production,
reflects
on
direct
indirect
RONS,
addresses
diversity
terminology
used
different
fields
research,
provides
guidance
developing
harmonized
approach
defining
common
developer
community.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
254, С. 114757 - 114757
Опубликована: Март 10, 2023
Soil
and
water
are
increasingly
at
risk
of
contamination
from
the
toxic
heavy
metals
lead
(Pb)
cadmium
(Cd).
Arabis
paniculata
(Brassicaceae)
is
a
hyperaccumulator
(HMs)
found
widely
distributed
in
areas
impacts
by
mining
activities.
However,
mechanism
which
A.
tolerates
HMs
still
uncharacterized.
For
this
experiment,
we
employed
RNA
sequencing
(RNA-seq)
order
to
find
Cd
(0.25
mM)-
Pb
(2.50
mM)-coresponsive
genes
paniculata.
In
total,
4490
1804
differentially
expressed
(DEGs)
were
identified
root
tissue,
955
2209
DEGs
shoot
after
exposure,
respectively.
Interestingly
gene
expression
corresponded
similarly
both
Pd
27.48%
co-upregulated
41.00%
co-downregulated.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
Gene
Ontology
(GO)
analyses
showed
that
co-regulated
predominantly
involved
transcription
factors
(TFs),
cell
wall
biosynthesis,
metal
transport,
plant
hormone
signal
transduction,
antioxidant
enzyme
activity.
Many
critical
Pb/Cd-induced
phytohormone
biosynthesis
HM
also
identified.
Especially
ABCC9
was
co-downregulated
tissues
but
tissues.
The
co-downregulation
roots
prevented
entering
vacuole
rather
than
cytoplasm
for
transporting
shoots.
While
shoots,
results
vacuolar
accumulation,
may
explain
why
hyperaccumulator.
These
will
help
reveal
molecular
physiological
processes
underlying
tolerance
exposure
paniculata,
aid
future
efforts
utilize
phytoremediation.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 12
Опубликована: Фев. 3, 2022
Ischemic
stroke
is
a
leading
cause
of
disability
and
mortality
worldwide.
Thus,
it
urgent
to
explore
its
pathophysiological
mechanisms
find
new
therapeutic
strategies
for
successful
treatment.
The
relationship
between
oxidative
stress
ischemic
increasingly
appreciated
attracting
considerable
attention.
ROS
serves
as
source
stress.
It
byproduct
mitochondrial
metabolism
but
primarily
functional
product
NADPH
oxidases
(NOX)
family
members.
Nicotinamide
adenine
dinucleotide
phosphate
oxidase
4
(NOX4)
most
closely
related
the
formation
during
stroke.
Its
expression
significantly
upregulated
after
cerebral
ischemia,
making
promising
target
treating
Several
drugs
targeting
NOX4,
such
SCM-198,
Iso,
G-Rb1,
betulinic
acid,
electroacupuncture,
have
shown
efficacy
treatments
MTfp-NOX4
POC
provides
novel
insight
treatment
Combinations
these
therapies
also
provide
approaches
therapy
In
this
review,
we
summarize
subcellular
location,
expression,
NOX4
in
occurrence
development
We
discuss
regulatory
further
comment
on
shortcomings
current
NOX4-targeted
studies
direction
improvement.
Water,
Год журнала:
2022,
Номер
14(23), С. 3980 - 3980
Опубликована: Дек. 6, 2022
Polycyclic
aromatic
hydrocarbons
(PAHs)
distributed
in
air
and
soil
are
harmful
because
of
their
carcinogenicity,
mutagenicity,
teratogenicity.
Biodegradation
is
an
environmentally
friendly
economical
approach
to
control
these
types
contaminants
has
become
essential
method
for
remediating
environments
contaminated
with
petroleum
hydrocarbons.
The
bacteria
isolated
identified
using
a
mineral
nutrient
medium
containing
PAHs
as
the
sole
source
carbon
energy
biochemical
differential
tests.
Thus,
this
study
focuses
on
some
fungi
that
degrade
oil
This
provides
comprehensive,
up-to-date,
efficient
overview
hydrocarbon
contaminant
bioremediation
considering
modification
by
microorganisms,
emphasizing
new
knowledge
gained
recent
years.
shows
acceptably
biodegradable
removal
cost-effective.
Moreover,
microbial
biodegradation
utilizes
enzymatic
catalytic
activities
microorganisms
increases
degradation
pollutants
several
times
compared
conventional
methods.
Biological
treatment
carried
out
two
ways:
stimulation
propagation.
In
first
method,
growth
indigenous
area
increases,
pollution
eliminated.
second
other
hand,
there
no
effective
area,
so
added
environment.
