Natural Product Communications,
Год журнала:
2025,
Номер
20(4)
Опубликована: Апрель 1, 2025
Traditional
medicine
has
played
a
key
role
in
cancer
treatment,
particularly
developing
countries
where
herbal
remedies
are
extensively
utilized.
Ethnopharmacological
knowledge
highlighted
several
medicinal
plants
traditionally
used
to
treat
cancers.
However,
only
fraction
of
these
have
undergone
scientific
evaluation
validate
their
anticancer
potential.
This
review
summarizes
the
ethnopharmacological
use,
preclinical
studies,
and
clinical
trial
data
plant-derived
compounds
with
properties.
Preclinical
investigations
demonstrated
substantial
cytotoxic
activities
plant
extracts
isolated
fractions
against
various
human
cell
lines.
For
instance,
from
Acokanthera
schimperi,
Clematis
simensis,
Euphorbia
schimperiana,
Kalanchoe
petitiana
,
Plumbago
zeylanicum
potent
across
types,
IC50
values
ranging
between
0.086
6.37
μg/mL.
Building
on
findings,
progressed
trials.
Curcumin
Curcuma
longa
is
undergoing
Phase
II
for
advanced
pancreatic
cancer.
Tea
polyphenols
*indole-3-carbinol/3,3-diindolylmethane
shown
efficacy
trials
multiple
myeloma
breast
cancer,
respectively.
Besides,
epigallocatechin,
lycopene,
resveratrol
(Polygonum,
sulforaphane
(
Brassica
oleracea
),
roscovitine/seliciclib,
thymoquinone,
piperine,
Berberine
genistein
under
I–III
integrates
knowledge,
data,
evidence,
showing
drug
discovery.
While
significant
progress
been
made,
further
studies
required
isolate,
characterize,
elucidate
mechanisms
action
bioactive
compounds.
Bridging
traditional
contemporary
research
offers
promising
avenues
development
novel
chemotherapeutic
chemopreventive
agents,
advancing
fight
Plants,
Год журнала:
2024,
Номер
13(2), С. 290 - 290
Опубликована: Янв. 18, 2024
Non-small-cell
lung
cancer
(NSCLC)
is
renowned
for
its
aggressive
and
highly
metastatic
nature.
In
recent
years,
there
has
been
a
surge
in
interest
regarding
the
therapeutic
potential
of
traditional
medicinal
plants.
Dracaena
loureirin
(D.
loureirin),
Ficus
racemosa
Linn.
(F.
racemosa),
Harrisonia
perforata
(Blanco)
Merr.
(H.
perforata)
are
prominent
herbs
Thailand,
recognized
their
diverse
biological
activities,
including
antipyretic
anti-inflammatory
effects.
However,
prospective
anti-cancer
properties
against
NSCLC
remain
largely
unexplored.
This
study
aimed
to
evaluate
attributes
ethanolic
extracts
obtained
from
D.
loureiri
(DLEE),
F.
(FREE),
H.
(HPEE)
A549
adenocarcinoma
cell
lines.
Sulforhodamine
B
(SRB)
assay
results
revealed
that
only
DLEE
exhibited
cytotoxic
effects
on
cells,
whereas
FREE
HPEE
showed
no
such
cytotoxicity.
To
elucidate
mechanisms
DLEE,
cycle
apoptosis
assays
were
performed.
The
findings
demonstrated
inhibited
proliferation
induced
arrest
at
G0/G1
phase
cells
through
downregulation
key
regulator
proteins,
cyclin
D1,
CDK-2,
CDK-4.
Furthermore,
treatment
facilitated
by
suppressing
anti-apoptotic
proteins
(Bcl-2,
Bcl-xl,
survivin)
enhancing
apoptotic
(cleaved-caspase-3
cleaved-PARP-1).
summary,
our
provides
novel
insights
into
significant
cells.
work
represents
first
report
suggesting
capability
impede
growth
induction
apoptosis.
Evidence-based Complementary and Alternative Medicine,
Год журнала:
2022,
Номер
2022, С. 1 - 19
Опубликована: Окт. 25, 2022
Cancer
is
one
of
the
major
medical
challenges,
with
an
unacceptably
high
death
toll
worldwide.
In
Morocco,
medicinal
plants
continue
to
play
a
pivotal
therapeutic
role
despite
development
modern
sanitation
systems.
current
study,
ethnobotanical
survey
was
carried
out
at
Moroccan
national
institute
oncology,
Rabat,
and
we
aimed
(1)
establishing
exhaustive
inventory
indigenous
knowledge
used
manage
cancer
(2)
confirming
reported
ethnopharmacological
uses
through
bibliometric
review.
An
conducted
291
patients
National
Institute
Oncology,
during
period
4
months,
from
February
May
2019,
semistructured
interviews.
Ethnobotanical
indices,
including
informant
consensus
factor
(FIC),
use
report
(UR),
relative
frequency
citation
(RFC),
botanical
family
value
(FUV),
fidelity
level
(FL),
index
agreement
on
remedies
(IAR),
were
employed
in
data
analyses.
The
revealed
that
39
belonging
27
families
38
genera
treat
cancer.
most
ethnospecies
Aristolochia
longa
highest
RFC
(0.096),
followed
by
Nigella
sativa,
Ephedra
alata,
Euphorbia
resinifera,
Lavandula
dentata,
éwith
values
0.072,
0.054,
0.044,
respectively.
regard
plant
families,
Lamiaceae
contributed
number
five
species
(FUV
=
0.034),
Asteraceae
(4
species;
FUV
0.020),
Fabaceae
0.020).
leaves
are
popular
part
studied
population
against
cancer;
otherwise,
decoction
commonly
method
for
remedy
preparation
FIC
noticed
uterine
treatment
(0.86).
Considering
these
findings,
further
investigations
into
recorded
should
be
performed
assess
phytochemical
constituents
pharmaceutical
benefits
order
identify
their
active
compounds
any
drug
formulations.
Chemical Biology & Drug Design,
Год журнала:
2023,
Номер
102(1), С. 177 - 200
Опубликована: Март 11, 2023
Abstract
Berberine
(BBR)
is
a
potential
plant
metabolite
and
has
remarkable
anticancer
properties.
Many
kinds
of
research
are
being
focused
on
the
cytotoxic
activity
berberine
in
vitro
vivo
studies.
A
variety
molecular
targets
which
lead
to
effect
ranges
from
p‐53
activation,
Cyclin
B
expression
for
arresting
cell
cycles;
protein
kinase
(AKT),
MAP
IKB
antiproliferative
activity;
beclin‐1
involved
autophagy;
reduced
MMP‐9
MMP‐2
inhibition
invasion
metastasis
etc.
also
interferes
with
transcription
factor‐1
(AP‐1)
responsible
oncogenes
neoplastic
transformation
cell.
It
leads
various
enzymes
directly
or
indirectly
carcinogenesis
like
N
acetyl
transferase,
Cyclo‐oxygenase‐2,
Telomerase
Topoisomerase.
In
addition
these
actions,
plays
role
in,
regulation
reactive
oxygen
species
inflammatory
cytokines
preventing
cancer
formation.
properties
demonstrated
due
interaction
micro‐RNA.
The
summarized
information
presented
this
review
article
may
help
researchers,
scientists/industry
persons
use
as
promising
candidate
against
cancer.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 17, 2023
Calotropin
is
a
pharmacologically
active
compound
isolated
from
milkweed
plants
like
Calotropis
procera,
gigantea,
and
Asclepias
currasavica
that
belong
to
the
Asclepiadaceae
family.
All
of
these
are
recognised
as
medical
traditional
used
in
Asian
countries.
identified
highly
potent
cardenolide
has
similar
chemical
structure
cardiac
glycosides
(such
digoxin
digitoxin).
During
last
few
years,
cytotoxic
antitumor
effects
cardenolides
have
been
reported
more
frequently.
Among
cardenolides,
calotropin
most
promising
agent.
In
this
updated
comprehensive
review,
we
aimed
analyze
discuss
specific
mechanisms
molecular
targets
cancer
treatment
open
new
perspectives
for
adjuvant
different
types
cancer.
The
on
extensively
studied
preclinical
pharmacological
studies
vitro
using
cell
lines
vivo
experimental
animal
models
targeted
anticancer
signaling
pathways.
analyzed
information
specialized
literature
was
obtained
scientific
databases
until
December
2022,
mainly
PubMed/MedLine,
Google
Scholar,
Scopus,
Web
Science,
Science
Direct
MeSH
search
terms.
results
our
analysis
demonstrate
can
be
potential
chemotherapeutic/chemopreventive
adjunctive
agent
pharmacotherapeutic
management.
