Review on the Ethnopharmacological Use of Medicinal Plants and Their Anticancer Activity from Preclinical to Clinical Trial DOI Creative Commons
Tafere Mulaw Belete, Alemante Tafese Beyna

Natural Product Communications, Год журнала: 2025, Номер 20(4)

Опубликована: Апрель 1, 2025

Traditional medicine has played a key role in cancer treatment, particularly developing countries where herbal remedies are extensively utilized. Ethnopharmacological knowledge highlighted several medicinal plants traditionally used to treat cancers. However, only fraction of these have undergone scientific evaluation validate their anticancer potential. This review summarizes the ethnopharmacological use, preclinical studies, and clinical trial data plant-derived compounds with properties. Preclinical investigations demonstrated substantial cytotoxic activities plant extracts isolated fractions against various human cell lines. For instance, from Acokanthera schimperi, Clematis simensis, Euphorbia schimperiana, Kalanchoe petitiana , Plumbago zeylanicum potent across types, IC50 values ranging between 0.086 6.37 μg/mL. Building on findings, progressed trials. Curcumin Curcuma longa is undergoing Phase II for advanced pancreatic cancer. Tea polyphenols *indole-3-carbinol/3,3-diindolylmethane shown efficacy trials multiple myeloma breast cancer, respectively. Besides, epigallocatechin, lycopene, resveratrol (Polygonum, sulforaphane ( Brassica oleracea ), roscovitine/seliciclib, thymoquinone, piperine, Berberine genistein under I–III integrates knowledge, data, evidence, showing drug discovery. While significant progress been made, further studies required isolate, characterize, elucidate mechanisms action bioactive compounds. Bridging traditional contemporary research offers promising avenues development novel chemotherapeutic chemopreventive agents, advancing fight

Язык: Английский

Chitosan based composite scaffolds in skin wound repair: A review DOI
Anuradha Biswal, Shuvendu S. Purohit, Sarat K. Swain

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 84, С. 104549 - 104549

Опубликована: Май 9, 2023

Язык: Английский

Процитировано

32

Exploring the Anticancer Potential of Traditional Thai Medicinal Plants: A Focus on Dracaena loureiri and Its Effects on Non-Small-Cell Lung Cancer DOI Creative Commons
Xiaomin Huang, Punnida Arjsri, Kamonwan Srisawad

и другие.

Plants, Год журнала: 2024, Номер 13(2), С. 290 - 290

Опубликована: Янв. 18, 2024

Non-small-cell lung cancer (NSCLC) is renowned for its aggressive and highly metastatic nature. In recent years, there has been a surge in interest regarding the therapeutic potential of traditional medicinal plants. Dracaena loureirin (D. loureirin), Ficus racemosa Linn. (F. racemosa), Harrisonia perforata (Blanco) Merr. (H. perforata) are prominent herbs Thailand, recognized their diverse biological activities, including antipyretic anti-inflammatory effects. However, prospective anti-cancer properties against NSCLC remain largely unexplored. This study aimed to evaluate attributes ethanolic extracts obtained from D. loureiri (DLEE), F. (FREE), H. (HPEE) A549 adenocarcinoma cell lines. Sulforhodamine B (SRB) assay results revealed that only DLEE exhibited cytotoxic effects on cells, whereas FREE HPEE showed no such cytotoxicity. To elucidate mechanisms DLEE, cycle apoptosis assays were performed. The findings demonstrated inhibited proliferation induced arrest at G0/G1 phase cells through downregulation key regulator proteins, cyclin D1, CDK-2, CDK-4. Furthermore, treatment facilitated by suppressing anti-apoptotic proteins (Bcl-2, Bcl-xl, survivin) enhancing apoptotic (cleaved-caspase-3 cleaved-PARP-1). summary, our provides novel insights into significant cells. work represents first report suggesting capability impede growth induction apoptosis.

Язык: Английский

Процитировано

13

Exploring the Therapeutic Potential of Bioactive Compounds from Plant Sources DOI

Vivek Chintada,

Narasimha Golla

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence DOI Open Access
Naoufal El Hachlafi, Nesrine Benkhaira, Mohamed Ferioun

и другие.

Evidence-based Complementary and Alternative Medicine, Год журнала: 2022, Номер 2022, С. 1 - 19

Опубликована: Окт. 25, 2022

Cancer is one of the major medical challenges, with an unacceptably high death toll worldwide. In Morocco, medicinal plants continue to play a pivotal therapeutic role despite development modern sanitation systems. current study, ethnobotanical survey was carried out at Moroccan national institute oncology, Rabat, and we aimed (1) establishing exhaustive inventory indigenous knowledge used manage cancer (2) confirming reported ethnopharmacological uses through bibliometric review. An conducted 291 patients National Institute Oncology, during period 4 months, from February May 2019, semistructured interviews. Ethnobotanical indices, including informant consensus factor (FIC), use report (UR), relative frequency citation (RFC), botanical family value (FUV), fidelity level (FL), index agreement on remedies (IAR), were employed in data analyses. The revealed that 39 belonging 27 families 38 genera treat cancer. most ethnospecies Aristolochia longa highest RFC (0.096), followed by Nigella sativa, Ephedra alata, Euphorbia resinifera, Lavandula dentata, éwith values 0.072, 0.054, 0.044, respectively. regard plant families, Lamiaceae contributed number five species (FUV = 0.034), Asteraceae (4 species; FUV 0.020), Fabaceae 0.020). leaves are popular part studied population against cancer; otherwise, decoction commonly method for remedy preparation FIC noticed uterine treatment (0.86). Considering these findings, further investigations into recorded should be performed assess phytochemical constituents pharmaceutical benefits order identify their active compounds any drug formulations.

Язык: Английский

Процитировано

29

Current understanding and future prospects on Berberine for anticancer therapy DOI
Anjana Goel

Chemical Biology & Drug Design, Год журнала: 2023, Номер 102(1), С. 177 - 200

Опубликована: Март 11, 2023

Abstract Berberine (BBR) is a potential plant metabolite and has remarkable anticancer properties. Many kinds of research are being focused on the cytotoxic activity berberine in vitro vivo studies. A variety molecular targets which lead to effect ranges from p‐53 activation, Cyclin B expression for arresting cell cycles; protein kinase (AKT), MAP IKB antiproliferative activity; beclin‐1 involved autophagy; reduced MMP‐9 MMP‐2 inhibition invasion metastasis etc. also interferes with transcription factor‐1 (AP‐1) responsible oncogenes neoplastic transformation cell. It leads various enzymes directly or indirectly carcinogenesis like N acetyl transferase, Cyclo‐oxygenase‐2, Telomerase Topoisomerase. In addition these actions, plays role in, regulation reactive oxygen species inflammatory cytokines preventing cancer formation. properties demonstrated due interaction micro‐RNA. The summarized information presented this review article may help researchers, scientists/industry persons use as promising candidate against cancer.

Язык: Английский

Процитировано

22

The mechanism of dioscin preventing lung cancer based on network pharmacology and experimental validation DOI
Xi Peng, Yuji Niu, Yaru Zhang

и другие.

Journal of Ethnopharmacology, Год журнала: 2022, Номер 292, С. 115138 - 115138

Опубликована: Март 1, 2022

Язык: Английский

Процитировано

29

Berberine regulates PADI4-related macrophage function to prevent lung cancer DOI
Wenwen Gu, Mengdi Zhang, Fan Gao

и другие.

International Immunopharmacology, Год журнала: 2022, Номер 110, С. 108965 - 108965

Опубликована: Июнь 25, 2022

Язык: Английский

Процитировано

28

An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer DOI Creative Commons
Jovana Rajković, R Novaković, Jelica Grujić-Milanović

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Апрель 17, 2023

Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these are recognised as medical traditional used in Asian countries. identified highly potent cardenolide has similar chemical structure cardiac glycosides (such digoxin digitoxin). During last few years, cytotoxic antitumor effects cardenolides have been reported more frequently. Among cardenolides, calotropin most promising agent. In this updated comprehensive review, we aimed analyze discuss specific mechanisms molecular targets cancer treatment open new perspectives for adjuvant different types cancer. The on extensively studied preclinical pharmacological studies vitro using cell lines vivo experimental animal models targeted anticancer signaling pathways. analyzed information specialized literature was obtained scientific databases until December 2022, mainly PubMed/MedLine, Google Scholar, Scopus, Web Science, Science Direct MeSH search terms. results our analysis demonstrate can be potential chemotherapeutic/chemopreventive adjunctive agent pharmacotherapeutic management.

Язык: Английский

Процитировано

12

Myricetin: a potential plant-derived anticancer bioactive compound—an updated overview DOI
Suneel Kumar, Nitin Swamy, Hardeep Singh Tuli

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 396(10), С. 2179 - 2196

Опубликована: Апрель 21, 2023

Язык: Английский

Процитировано

12

Thapsigargin and its prodrug derivatives: exploring novel approaches for targeted cancer therapy through calcium signaling disruption DOI

Iqra Khurram,

Muhammad Umer Khan,

S.M. Ibrahim

и другие.

Medical Oncology, Год журнала: 2024, Номер 42(1)

Опубликована: Ноя. 19, 2024

Язык: Английский

Процитировано

5