Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis

Phytomedicine, Год журнала: 2024, Номер 128, С. 155258 - 155258

Опубликована: Янв. 11, 2024

Язык: Английский

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Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Дек. 6, 2022

Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long history of treating dysentery in the clinic. Over past two decades, polytrophic, pharmacological, and biochemical properties BBR have been intensively studied. The key functions BBR, including anti-inflammation, antibacterial, antioxidant, anti-obesity, even antitumor, discovered. However, underlying mechanisms BBR-mediated regulation still need to be explored. Given that is also natural nutrition supplement, modulatory effects on nutritional immune responses attracted more attention investigators. In this mini-review, we summarized latest achievements inflammation, gut microbes, macrophage polarization, associated with their possible tools pathogenesis therapy ulcerative colitis cancer recent 5 years. We discuss therapeutic efficacy anti-inflammatory actions benefit future clinical applications.

Язык: Английский

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Recent advances in natural small molecules as drug delivery systems

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(21), С. 4584 - 4599

Опубликована: Янв. 1, 2023

Drug delivery systems (DDSs) are a multidisciplinary approach toward the effective of drugs to their target sites. Natural small molecule (NSM) compounds with anticancer activity, self-assembly and co-assembly functions show great potential for application as novel DDSs in biomedical field. NSMs widely sourced, have many modification sites, readily form hydrogen bonds, π-π interactions, van der Waals other non-covalent bonds solvents, resulting ordered structures. Moreover, good biocompatibility bioactivity allow compositions based on these be used life science applications such tissue engineering, drug cell imaging, showing medical value DDSs. In this review, we summarise role, assembly principles natural products triterpenoids, diterpenoids, sterols, alkaloids polysaccharides construction systems, which expected provide an important reference development more active nanomaterials study single or multi-component interactions.

Язык: Английский

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DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma

Cancer Research, Год журнала: 2024, Номер 84(10), С. 1613 - 1629

Опубликована: Фев. 21, 2024

Abstract Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8+ T cells impair antitumor immunity thereby HCC progression. TGFβ1 induced which recruited cells. Binding NET-DNA inhibited function while increasing apoptosis secretion, forming positive feedback loop further stimulate formation immunosuppression. Mechanistically, N-terminus TMCO6 interacted with suppressed T-cell receptor signaling NFκB p65 nuclear translocation. Blocking inhibiting PAD4 potent effects wild-type mice but not TMCO6−/− mice. In clinical samples, expressing had an exhausted phenotype. inhibition or deficiency combined anti-PD-1 abolished NET-driven vivo. Collectively, this study unveils role impairing binding identifies targeting axis as immunotherapeutic strategy blocking Significance: is mediates dysfunction HCC, indicating NET-TMCO6 promising target overcoming immunosuppression

Язык: Английский

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Nanotechnology-empowered lung cancer therapy: From EMT role in cancer metastasis to application of nanoengineered structures for modulating growth and metastasis

Environmental Research, Год журнала: 2023, Номер 232, С. 115942 - 115942

Опубликована: Апрель 19, 2023

Язык: Английский

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Unlocking the potential of Berberine: Advancing cancer therapy through chemosensitization and combination treatments

Cancer Letters, Год журнала: 2024, Номер 597, С. 217019 - 217019

Опубликована: Июнь 5, 2024

Язык: Английский

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Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Phytotherapy Research, Год журнала: 2024, Номер 38(8), С. 4336 - 4350

Опубликована: Июль 12, 2024

Lung cancer is the second most prevalent and ranks first in cancer-related death worldwide. Due to resistance development conventional therapy strategies, including chemotherapy, radiotherapy, targeted therapy, immunotherapy, various natural products their extracts have been revealed as alternatives. Berberine (BBR), which present stem, root, bark of trees, could exert anticancer activities by regulating tumor cell proliferation, apoptosis, autophagy, metastasis, angiogenesis, immune responses via modulating several signaling pathways within microenvironment. its poor water solubility, pharmacokinetics/bioavailability profile, extensive p-glycoprotein-dependent efflux, BBR application (pre) clinical studies restricted. To overcome these limitations, can be encapsulated nanoparticle (NP)-based drug delivery systems, monotherapy or combinational improve therapeutic efficacy. Nanoformulations also facilitate selective into lung cells. In addition BBR, especially cancer, here we reviewed nanoformulations, polymeric NPs, metal-based carbon nanostructures, others, treatment cancer.

Язык: Английский

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Natural Products with Anti-tumorigenesis Potential Targeting Macrophage

Phytomedicine, Год журнала: 2024, Номер 131, С. 155794 - 155794

Опубликована: Июнь 1, 2024

Язык: Английский

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Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(24), С. 15827 - 15827

Опубликована: Дек. 13, 2022

Neutrophils represent the most abundant cell type of leukocytes in human blood and have been considered a vital player innate immune system first line defense against invading pathogens. Recently, several studies showed that neutrophils play an active role response during cancer development. They exhibited both pro-oncogenic anti-tumor activities under influence various mediators tumor microenvironment. can be divided into subpopulations, thus contradicting traditional concept as homogeneous population with specific function immunity opening new horizons for therapy. Despite promising achievements this field, full understanding tumor–neutrophil interplay is currently lacking. In review, we try to summarize current view on neutrophil heterogeneity cancer, discuss different communication pathways between tumors neutrophils, focus implementation these findings develop neutrophil-based therapies.

Язык: Английский

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Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 396(12), С. 3595 - 3603

Опубликована: Июнь 2, 2023

Abstract Lung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more than 1.9 million cases each year due to its complex and poorly understood molecular mechanisms that result in unregulated cell proliferation metastasis. β-Catenin a developmentally active protein controls proliferation, metastasis, polarity fate during homeostasis aids progression via epithelial–mesenchymal transition. Therefore, inhibition β-catenin pathway could attenuate LC. Berberine, an isoquinoline alkaloid which known anti-cancer anti-inflammatory properties, demonstrates poor solubility bioavailability. In our study, we have encapsulated berberine into liquid crystalline nanoparticles improve physiochemical functions studied if these target inhibit human lung adenocarcinoma line (A549) at both gene levels. We observed first time 5 µM significantly expression protein. The interaction between was further validated by simulation studies. Targeting with represents promising strategy management progression.

Язык: Английский

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