Acta Facultatis Medicae Naissensis,
Год журнала:
2024,
Номер
41(1), С. 5 - 9
Опубликована: Янв. 1, 2024
People
with
circadian
rhythm
disturbances
are
at
an
elevated
risk
of
mental
disorders,
and
conversely,
those
disorders
more
susceptible
to
the
disruption.
A
steady
cycle
sleep
wakefulness
that
is
phase-shifted
relative
prior
local
solar
time
may
be
characterized
by
a
short
endogenous
period.
Advanced
sleep-wake
phase
disorder
(ASPD)
substantial
advancement
phase,
followed
sleep-related
symptoms.
ASPD
challenging
manage,
current
treatment
options
varying
in
efficacy
potential
side
effects.
Further
research
needed
identify
effective
elucidate
underlying
mechanisms
ASPD.
More
better
understand
molecular
metabolic
changes
associated
aging
contribute
development
disorder.
Psychiatry and Clinical Neurosciences,
Год журнала:
2022,
Номер
77(2), С. 84 - 93
Опубликована: Ноя. 17, 2022
Although
some
patients
have
persistent
symptoms
or
develop
new
following
coronavirus
disease
2019
(COVID-19)
infection,
neuropsychiatric
aspects
of
long
COVID
are
not
well
known.
This
review
summarizes
and
provides
an
update
on
the
dimensions
COVID.
Its
manifestations
commonly
include
fatigue,
cognitive
impairment,
sleep
disorders,
depression,
anxiety,
post-traumatic
stress
disorder.
There
no
specific
tests
for
COVID,
but
characteristic
findings
such
as
hypometabolism
positron
emission
tomography
been
reported.
The
possible
mechanisms
inflammation,
ischemic
effects,
direct
viral
invasion,
social
environmental
changes.
Some
patient
characteristics
severity
complications
acute
COVID-19
infection
may
be
associated
with
increased
risk
symptoms.
Long
resolve
spontaneously
persist,
depending
type
established
treatments
lacking,
various
psychological
pharmacological
attempted.
Vaccination
against
plays
a
key
role
in
prevention
disease.
With
differences
among
SARS-CoV-2
variants,
including
omicron
variant,
likely
to
change
future.
Further
studies
clarifying
effective
warranted.
Post
COVID-19
syndrome,
also
known
as
"Long
COVID,"
is
a
complex
and
multifaceted
condition
that
affects
individuals
who
have
recovered
from
SARS-CoV-2
infection.
This
systematic
review
meta-analysis
aim
to
comprehensively
assess
the
global
prevalence
of
depression,
anxiety,
sleep
disorder
in
coping
with
syndrome.
This
study
carried
out
to
examine
the
effects
of
nursing
care
given
coronary
intensive
patients
according
their
circadian
rhythms
on
sleep
quality,
pain,
anxiety,
and
delirium.
was
designed
as
a
randomised
controlled,
clinical
investigation.
The
population
consisted
treated
in
unit
training
research
hospital
between
September
2022
February
2023.
Total
44
participants
were
included.
included
followed
up
for
3
days
unit.
Data
collected
using
"Patient
Information
Form,
Sleep
Quality
Scale
Coronary
Intensive
Care
Patients
(SQ-CC),
Visual
Analogue
(VAS),
Morningness-Eveningness
Questionnaire
(MEQ),
Hospital
Anxiety
Depression
(HADS),
Delirium
Screening
Checklist
(ICDSC)."
In
addition,
melatonin
cortisol
measurements
made,
data
taken
with
smartwatch.
intermediate
chronotype,
delirium,
ventilator
support,
or
sedative
drugs
excluded.
chronotypes
determined,
intervention
group
by
rhythms.
No
made
control
group,
routine
continued
accordance
functioning.
Frequency
distribution,
dependent
independent
sample
t-test,
Wilcoxon
test,
repeated
measures
analysis
variance,
Mann
Whitney
U,
chi-square
used
evaluate
data.
has
been
registered
ClinicalTrials.gov
(Identifiers:
NCT04934436).
During
statistical
analysis,
groups
coded
Group
A
B,
ensuring
blinding
statistician.
group's
quality
increased
compared
(post-test
SQ-CC
total
scores:
22.41
±
6.67
vs.
50.45
10.63,
p
<
0.001).
Although
no
significant
difference
found
result
study,
there
decrease
pain
score
(VAS
pre-test:
1.55
2.15,
post-test:
0.68
2.21,
=
0.036).
anxiety
decreased
significantly
HADS-Anxiety
3.18
3.29
8.50
5.66,
post-test
delirium
higher
ICDSC
0.32
0.48
1.18
0.50,
Melatonin
both
without
statistically
differences
them
(melatonin
levels:
>
0.05).
Considering
sound
levels
environment,
first-night
decibel
mean
than
(first-night
mean:
56.58
2.43
dB
54.51
2.41
dB,
Finally,
smartwatch
show
times
(p
0.05),
but
had
more
deep
sleep,
while
less
sleep.
Nursing
rhythm
increases
reduces
risk
acute
syndrome
Current Alzheimer Research,
Год журнала:
2022,
Номер
19(9), С. 641 - 657
Опубликована: Авг. 1, 2022
Abstract:
The
COVID-19
pandemic
is
caused
by
the
severe
acute
respiratory
syndrome
coronavirus
(SARS-CoV-2),
a
pathogen
with
neuroinvasive
potential.
Neurological
manifestations
include
loss
of
smell
and
taste,
headache,
dizziness,
stroke,
potentially
fatal
encephalitis.
Several
studies
found
elevated
proinflammatory
cytokines,
such
as
TNF-α,
IFN-γ,
IL-6
IL-8,
IL-
10
IL-16,
IL-17A,
IL-18
in
severely
critically
ill
patients
may
persist
even
after
apparent
recovery
from
infection.
Biomarker
on
CSF
plasma
serum
have
also
shown
high
level
IL-6,
intrathecal
IgG,
neurofilament
light
chain
(NFL),
glial
fibrillary
acidic
protein
(GFAP),
tau
protein.
Emerging
evidence
matter
has
established
concept
COVID-19-associated
neuroinflammation,
context
cytokine
storm.
While
short-term
implications
this
condition
are
extensively
documented,
its
longterm
yet
to
be
understood.
association
aforementioned
cytokines
pathogenesis
neurodegenerative
diseases,
including
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis,
increase
patients'
risk
developing
diseases.
Analysis
biomarkers
can
contribute
early
detection
disease's
exacerbation,
monitoring
neurological
disease
devising
scales,
identifying
treatment
targets.
