Molecular mechanism of nanomaterials induced liver injury: A review
World Journal of Hepatology,
Год журнала:
2024,
Номер
16(4), С. 566 - 600
Опубликована: Апрель 24, 2024
The
unique
physicochemical
properties
inherent
to
nanoscale
materials
have
unveiled
numerous
potential
applications,
spanning
beyond
the
pharmaceutical
and
medical
sectors
into
various
consumer
industries
like
food
cosmetics.
Consequently,
humans
encounter
nanomaterials
through
diverse
exposure
routes,
giving
rise
health
considerations.
Noteworthy
among
these
are
silica
specific
metallic
nanoparticles,
extensively
utilized
in
products,
which
garnered
substantial
attention
due
their
propensity
accumulate
induce
adverse
effects
liver.
This
review
paper
aims
provide
an
exhaustive
examination
of
molecular
mechanisms
underpinning
nanomaterial-induced
hepatotoxicity,
drawing
insights
from
both
vitro
vivo
studies.
Primarily,
most
frequently
observed
manifestations
toxicity
following
cells
or
animal
models
involve
initiation
oxidative
stress
inflammation.
Additionally,
we
delve
existing
employed
for
evaluating
hepatotoxic
nanomaterials,
emphasizing
persistent
endeavors
advance
bolster
reliability
nanotoxicology
research.
Язык: Английский
Exposure to low dose of Bisphenol A (BPA) intensifies kidney oxidative stress, inflammatory factors expression and modulates Angiotensin II signaling under hypertensive milieu
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2023,
Номер
38(1)
Опубликована: Сен. 18, 2023
Abstract
Humans
are
constantly
exposed
to
low
concentrations
of
ubiquitous
environmental
pollutant,
Bisphenol
A
(BPA).
Due
the
prevalence
hypertension
(one
major
risk
factors
cardiovascular
disease
[CVD])
in
population,
it
is
necessary
explore
adverse
effect
BPA
under
associated
pathogenic
milieu.
The
current
study
Nω‐nitro‐
l
‐arginine
methyl
ester
(L‐NAME)
induced
hypertensive
Wistar
rats
dose
(50
μg/kg)
for
30
days
period.
In
tissue
samples
immunohistochemistry,
real‐time
quantitative
polymerase
chain
reaction
and
enzymatic
assays
were
conducted.
Moreover,
studies
on
primary
kidney
cell
culture
employed
impact
exposure
at
nanomolar
level
(20−80
nM
range)
renal
cells
through
various
fluorescence
assays.
observed
results
illustrate
that
potentiates/aggravates
abnormalities
(renal
fibrosis),
oxidative
stress
(ROS
generation),
elevated
angiotensin‐converting
enzyme
activity,
malfunction
antioxidant
tricarboxylic
acid
cycle
enzymes,
lipid
inflammatory
factor
expression
(both
messenger
RNA
protein
TNF‐α
IL‐6).
Further,
vitro
levels
modulates
superoxide
total
ROS),
mitochondrial
physiology
(reduced
transmembrane
potential—∆ψm)
peroxidation
a
dependent
manner.
addition,
angiotensin
II
ROS
generation
was
aggravated
further
by
during
coexposure
cells.
Therefore,
assessment,
precise
investigation
(CVD
vulnerable)
populations
highly
suggested.
Язык: Английский
Short-term exposure of 2.4 GHz electromagnetic radiation on cellular ROS generation and apoptosis in SH-SY5Y cell line and impact on developing chick embryo brain tissue
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Янв. 21, 2025
Язык: Английский
Phase-dependent hepatotoxicity of Aluminum oxide nanoparticles mediated through the intestinal microbiota
Environment International,
Год журнала:
2025,
Номер
unknown, С. 109398 - 109398
Опубликована: Март 1, 2025
Aluminum
oxide
(Al2O3)
nanoparticles
(NPs)
are
extensively
utilized
in
the
food
industry
for
applications
such
as
packaging,
antimicrobial
coatings,
processing
equipment,
and
additives.
Despite
their
widespread
use,
mechanisms
underlying
Al2O3
NP-induced
hepatotoxicity
relationship
between
physicochemical
properties
toxicity
remain
inadequately
understood.
In
this
study,
we
explored
hepatotoxic
effects
of
α-Al2O3
γ-Al2O3
NPs
rats
subjected
to
oral
exposure
28
days.
Employing
an
integrated
metabolomics
microbiome
approach,
aimed
elucidate
potential
involved.
Our
findings
revealed
distinct
profiles
NPs,
potentially
mediated
by
differential
interactions
with
intestinal
microbiome.
exhibited
reduced
hepatotoxicity,
evidenced
minimal
liver
oxidative
stress,
which
may
be
associated
upregulation
digestion-related
flora
Peptococcaceae
Romboutsia,
influencing
accumulation
liver.
Conversely,
demonstrated
pronounced
characterized
histopathological
changes
elevated
levels
alanine
aminotransferase,
malondialdehyde,
glutathione.
This
increased
was
correlated
alterations
flora,
including
Ruminococcaceae
Exiguobacterium,
affected
metabolites
like
L-phenylalanine
arachidonic
acid,
contributing
hepatotoxicity.
The
results
underscore
importance
mediating
determining
differences
toxicities
different
NP
phases.
study
provides
valuable
insights
into
toxicological
impacts
phases,
paving
way
safer
nanomaterial
design
application
industry.
Язык: Английский
Human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during titanium dioxide nanoparticle (TiO2-NP) exposure
Molecular Omics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
increasing
exposure
to
nanoparticles
raises
a
concern
over
their
toxicity.
Язык: Английский
Bisphenol A (BPA) exposure aggravates hepatic oxidative stress and inflammatory response under hypertensive milieu – Impact of low dose on hepatocytes and influence of MAPK and ER stress pathways
Food and Chemical Toxicology,
Год журнала:
2023,
Номер
183, С. 114197 - 114197
Опубликована: Ноя. 27, 2023
Язык: Английский
Polyhydroxybutyrate (PHB)-Based sustainable bioplastic derived from Bacillus sp. KE4 isolated from kitchen waste effluent
Sustainable Chemistry and Pharmacy,
Год журнала:
2024,
Номер
39, С. 101507 - 101507
Опубликована: Март 26, 2024
Язык: Английский
Bacterial valorization of agricultural-waste into a nano-sized cellulosic matrix for mitigating emerging pharmaceutical pollutants: An eco-benign approach
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
277, С. 133684 - 133684
Опубликована: Июль 31, 2024
Язык: Английский
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) exposure induces hepatotoxicity and nephrotoxicity – role of oxidative stress, mitochondrial dysfunction and pathways of cytotoxicity
Toxicology Research,
Год журнала:
2024,
Номер
13(5)
Опубликована: Сен. 2, 2024
Abstract
Objective
Bisphenol
A
(BPA)
is
a
ubiquitous
pollutant
worldwide
and
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene
(MBP)
considered
major
active
metabolite
of
BPA
with
wide
range
potent
toxicological
properties.
However,
its
adverse
outcome
pathway
(AOP)
on
the
hepatic
renal
system
has
not
yet
been
explored.
Methods
Hence,
current
study
evaluated
effect
cell
survival,
oxidative
stress,
apoptosis.
In
addition,
influence
signalling
pathways
cytotoxicity
ROS
generating
enzymes
(NOX2
XO)
stress
was
explored
by
siRNA
knockdown
experiments.
Further,
molecular
interaction
SOD,
CAT,
HSA
(molecular
docking
dynamics)
validated
spectroscopy
(fluorescence
FTIR)
based
methods.
Results
The
indicates
that
MBP
exposure
dose
dependently
increased
cytotoxic
response,
apoptosis
in
both
hepatocytes
kidney
cells.
MAPK
influenced
overall
response
stimulatory
inhibitory
(SOD
CAT)
effects
were
observed,
along
robust
HSA.
Conclusions
observation
illustrates
adversely
impacts
cells
through
relevant
which
may
connect
missing
links
during
risk
assessment
BPA.
Язык: Английский