Exercise leads to sex-specific recovery of behavior and pathological AD markers following adolescent ethanol exposure in the TgF344-AD model DOI Creative Commons

Nicole L. Reitz,

Polliana T. Nunes,

Lisa M. Savage

и другие.

Frontiers in Behavioral Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Авг. 1, 2024

Introduction Human epidemiological studies suggest that heavy alcohol consumption may lead to earlier onset of Alzheimer’s Disease (AD), especially in individuals with a genetic predisposition for AD. Alcohol-related brain damage (ARBD) during critical developmental timepoint, such as adolescence, interacts AD-related pathologies accelerate disease progression later life. The current study investigates if voluntary exercise mid-adulthood can recover memory deficits caused by the interactions between adolescence ethanol exposure and AD-transgenes. Methods Male female TgF344-AD wildtype F344 rats were exposed an intragastric gavage water (control) or 5 g/kg 20% (adolescent intermittent ethanol; AIE) 2 day on/off schedule throughout (PD27-57). At 6 months old, either remained their home cage (stationary) placed wheel running apparatus 4 weeks then underwent several behavioral tests. number cholinergic neurons basal forebrain measure neurogenesis hippocampus assessed. Results Voluntary recovers spatial working selectively AIE improves pattern separation impairment seen control rats. There sex-dependent effects on pathology: Exercise integration recently born AIE-exposed led decrease amyloid burden entorhinal cortex, but only male Although was not affected AD-transgenes sex, did reduce Discussion These data provide support even after symptom onset, AD related cognitive decline associated neuropathologies be rescued unique sex-specific ways.

Язык: Английский

Exercise Ameliorates Dysregulated Mitochondrial Fission, Mitochondrial Respiration, and Neuronal Apoptosis in Parkinson’s Disease Mice via the Irisin/AMPK/SIRT1 Pathway DOI
Nan Li, Bin Wang, Yuanxin Wang

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Язык: Английский

Процитировано

1
Structural-Activity Relationship of Rare Ginsenosides from Red Ginseng in the Treatment of Alzheimer’s Disease DOI Open Access
Xianwen Ye, Haixia Zhang, Qian Li

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 8625 - 8625

Опубликована: Май 11, 2023

Rare ginsenosides are the major components of red ginseng. However, there has been little research into relationship between structure and their anti-inflammatory activity. In this work, BV-2 cells induced by lipopolysaccharide (LPS) or nigericin, activity eight rare ginsenosides, target proteins expression AD were compared. addition, Morris water maze test, HE staining, thioflavins urine metabonomics used to evaluate effect Rh4 on mice. Our results showed that configuration influences ginsenosides. Ginsenosides Rk1, Rg5, Rk3, have significant compared S-Rh1, R-Rh1, S-Rg3, R-Rg3. S-Rh1 S-Rg3 more pronounced than R-Rh1 R-Rg3, respectively. Furthermore, two pairs stereoisomeric can significantly reduce level NLRP3, caspase-1, ASC in cells. Interestingly, improve learning ability mice, cognitive impairment, hippocampal neuronal apoptosis Aβ deposition, regulate AD-related pathways such as tricarboxylic acid cycle sphingolipid metabolism. findings conclude with a double bond those without, 20(S)-ginsenosides excellent 20(R)-ginsenosides.

Язык: Английский

Процитировано

14
Abnormal amyloid precursor protein processing in periodontal tissue in a murine model of periodontitis induced by Porphyromonas gingivalis DOI
Hui Shen, Yiting Jiang,

Che Qiu

и другие.

Journal of Periodontal Research, Год журнала: 2024, Номер 59(2), С. 395 - 407

Опубликована: Фев. 4, 2024

Abstract Objective The study aimed to investigate the change of amyloid precursor protein (APP) processing and β (Aβ) metabolites in linking periodontitis Alzheimer's disease (AD). Background Aβ is one main pathological features AD, few studies have discussed changes its expression peripheral tissues or analyzed relationship between imbalance production clearance. Methods A murine model was established by oral infection with Porphyromonas gingivalis (P. gingivalis) . Micro‐computed tomography (Micro‐CT) used observe destruction alveolar bone. Nested quantitative polymerase chain reaction (qPCR) measure small quantities P.gingivalis DNA different tissues. Behavioral experiments were performed cognitive function mice. mRNA levels TNF‐α , IL‐6 IL‐8 RANKL OPG APP695 APP751 APP770 BACE1 gingival cortex detected RT‐PCR. Aβ1‐40 Aβ1‐42 crevicular fluid (GCF) plasma tested ELISA. Results P. found cause bone resorption impaired learning memory. gingiva, blood group nested qPCR ( p < .05). RANKL/OPG tissue significantly higher than that control Similarly, upregulated observed tissuses GCF those Conclusion can directly invade brain via hematogenous infection. invasion could trigger an immune response lead clearance tissues, which may abnormal metabolite brain, resulting occurrence development AD.

Язык: Английский

Процитировано

6
Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activity DOI
Mingyue Li, Jinghui Xu, Lili Li

и другие.

Experimental Neurology, Год журнала: 2024, Номер 376, С. 114770 - 114770

Опубликована: Апрель 4, 2024

Язык: Английский

Процитировано

6
Unveiling the potential of estrogen: Exploring its role in neuropsychiatric disorders and exercise intervention DOI Creative Commons

Wenke He,

Sen Zhang, Zhengtang Qi

и другие.

Pharmacological Research, Год журнала: 2024, Номер 204, С. 107201 - 107201

Опубликована: Май 3, 2024

Neuropsychiatric disorders shorten human life spans through multiple ways and become major threats to health. Exercise can regulate the estrogen signaling, which may be involved in depression, Alzheimer's disease (AD) Parkinson's (PD), other neuropsychiatric as well their sex differences. In nervous system, is an important regulator of cell development, synaptic brain connectivity. Therefore, this review aimed investigate potential system exercise intervention better understand its specific. exert a protective effect regulating expression receptors, are neuroprotection, neurodevelopment, neuronal glucose homeostasis. These processes mediated by downstream factors including N-myc regulatory gene 2 (Ndrg2), serotonin (5-HT), delta like canonical Notch ligand 1 (DLL1), NOD-like receptor thermal protein domain associated 3 (NLRP3), etc. addition, act on response element (ERE) fragment genes estrogenic β-amyloid precursor cleavase (BACE1). However, there few studies relationship between exercise, signaling pathway, disorders. Hence, we how mediates mechanism We aim provide theoretical perspective for affecting female health support design prescriptions.

Язык: Английский

Процитировано

6
Methylene Blue Pretreatment Protects Against Repeated Neonatal Isoflurane Exposure-Induced Brain Injury and Memory Loss DOI

Chongyun Wu,

Qianting Deng,

Ling Zhu

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер 61(8), С. 5787 - 5801

Опубликована: Янв. 17, 2024

Язык: Английский

Процитировано

5
The role of estrogen in Alzheimer’s disease pathogenesis and therapeutic potential in women DOI
Xinyi Wang,

Shu Feng,

Qianting Deng

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

5
Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis DOI

Yuhe Zhang,

Chen Yan,

Shushu Yuan

и другие.

Experimental Brain Research, Год журнала: 2023, Номер 241(6), С. 1661 - 1673

Опубликована: Май 18, 2023

Язык: Английский

Процитировано

11
Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity DOI Creative Commons
Zhihai Huang, Yulan Zhang,

Xiaohui Ma

и другие.

Theranostics, Год журнала: 2023, Номер 13(3), С. 913 - 930

Опубликована: Янв. 1, 2023

Rationale: Adverse experiences in early life including abuse, trauma and neglect, have been linked to poor physical mental health outcomes. Emerging evidence implies that those who experienced adversity (ELA) are more likely develop cognitive dysfunction depressive-like symptoms adulthood. The molecular mechanisms responsible for the negative consequences of ELA, however, remain unclear. In absence effective management options, anticipatory guidance is mainstay ELA prevention. Furthermore, there no available treatment prevents or alleviates neurologic sequelae especially traumatic stress. Hence, present study aims investigate these associations evaluate whether photobiomodulation (PBM), a non-invasive therapeutic procedure, can prevent behavioral manifestations later life. Methods: was induced by repeated inescapable electric foot shock rats from postnatal day 21 26. On immediately following last shock, 2-min daily PBM applied transcranially 7 consecutive days. Cognitive depression-like behaviors were measured battery tests Subsequently, oligodendrocyte progenitor cells (OPCs) differentiation, proliferation apoptosis lineage (OLs), mature oligodendrocyte, myelinating level oxidative damage, reactive oxygen species (ROS) total antioxidant capacity analyzed using immunofluorescence staining, capillary-based immunoassay (ProteinSimple®) assay kit. Results: exposed exhibited obvious dysfunction, reduction OPCs diminished generation survival OLs, decreased matured oligodendrocyte. deficit oligodendrocytes observed, conjunction with an imbalance redox homeostasis accumulated damage. These alternations concomitant behaviors. Importantly, we found largely prevented pathologies reversed resulting ELA. Conclusions: Collectively, findings provide new insights into mechanism which affects neurological Moreover, our support may be promising strategy ELA-induced develops

Язык: Английский

Процитировано

10
The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory with Respect to the Oxidative Status of Rats DOI

Gita Kholghi,

Vahide Alipour,

Maede Rezaie

и другие.

Neurochemical Research, Год журнала: 2023, Номер 48(7), С. 2077 - 2092

Опубликована: Фев. 14, 2023

Язык: Английский

Процитировано

10