Integrating network pharmacology with molecular docking and dynamics to uncover therapeutic targets and signaling mechanisms of vitamin D3 in Parkinson’s disease
Molecular Diversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Язык: Английский
Recent Insights on the Role of Nuclear Receptors in Alzheimer’s Disease: Mechanisms and Therapeutic Application
Xiaoxiao Shan,
Dawei Li,
Huihui Yin
и другие.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1207 - 1207
Опубликована: Янв. 30, 2025
Nuclear
receptors
(NRs)
are
ligand-activated
transcription
factors
that
regulate
a
broad
array
of
biological
processes,
including
inflammation,
lipid
metabolism,
cell
proliferation,
and
apoptosis.
Among
the
diverse
family
NRs,
peroxisome
proliferator-activated
(PPARs),
estrogen
receptor
(ER),
liver
X
(LXR),
farnesoid
(FXR),
retinoid
(RXR),
aryl
hydrocarbon
(AhR)
have
garnered
significant
attention
for
their
roles
in
neurodegenerative
diseases,
particularly
Alzheimer’s
disease
(AD).
NRs
influence
pathophysiology
AD
through
mechanisms
such
as
modulation
amyloid-beta
(Aβ)
deposition,
regulation
inflammatory
pathways,
improvement
neuronal
function.
However,
dual
role
progression,
where
some
may
exacerbate
while
others
offer
therapeutic
potential,
presents
critical
challenge
application
treatment.
This
review
explores
functional
diversity
highlighting
involvement
AD-related
processes
discussing
prospects
NR-targeting
strategies.
Furthermore,
key
challenges,
necessity
precise
identification
beneficial
detailed
structural
analysis
molecular
dynamics
simulations,
further
investigation
NR
AD,
tau
pathology
autophagy,
also
discussed.
Collectively,
continued
research
is
essential
to
clarify
ultimately
facilitating
potential
use
diagnosis,
prevention,
treatment
AD.
Язык: Английский
Endogenous 17β-estradiol regulates sexually dimorphic anxiety responses in zebrafish via the HPI axis and 5-HT/DA pathways
Frontiers in Marine Science,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 7, 2025
Anxiety
is
a
multifaceted
emotional
response
exhibited
by
animals
when
confronted
with
potential
threats.
Among
most
vertebrates,
including
mammals
and
fish,
there
pronounced
sexual
dimorphism
in
anxiety
responses,
females
typically
demonstrating
higher
levels
than
males.
Concurrently,
endogenous
estrogen
levels,
specifically
17β-estradiol
(E2),
are
significantly
compared
to
This
suggests
positive
regulatory
role
of
E2
on
anxiety,
contributing
sexually
dimorphic
fish.
To
elucidate
the
mediating
male
zebrafish
(
Danio
rerio
)
were
administered
(E2-M),
while
treated
letrozole
(LET,
an
aromatase
inhibitor
that
reduces
synthesis,
LET-F)
for
60
days,
plasma
brain
detected
was
evaluated
novel
tank
diving
test.
Females
(C-F)
showed
along
elevated
cortisol
brain,
reduced
serotonin
(5-HT)
dopamine
(DA)
males
(C-M).
Treatment
LET
decreased
female
zebrafish,
which
corresponded
lower
increased
5-HT
DA
content.
Additionally,
expression
genes
associated
E2,
cortisol,
5-
HT,
pathways
relevantly
altered.
Conversely,
treatment
(E2-M)
content,
corresponding
changes
gene
expression.
These
findings
strongly
suggest
positively
regulates
responses
possibly
modulating
synthesis
action
5-HT/DA
brain.
Язык: Английский
The role of estrogen in Alzheimer’s disease pathogenesis and therapeutic potential in women
Xinyi Wang,
Shu Feng,
Qianting Deng
и другие.
Molecular and Cellular Biochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Язык: Английский
Genome-wide association study of copy number variations in Parkinson's disease
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
Our
study
investigates
the
impact
of
copy
number
variations
(CNVs)
on
Parkinson's
disease
(PD)
pathogenesis
using
genome-wide
data,
aiming
to
uncover
novel
genetic
mechanisms
and
improve
understanding
role
CNVs
in
sporadic
PD.
Язык: Английский
Is exposure to Bisphenol A associated with Attention-Deficit Hyperactivity Disorder (ADHD) and associated executive or behavioral problems in children? A comprehensive systematic review.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
167, С. 105938 - 105938
Опубликована: Ноя. 16, 2024
Numerous
studies
have
investigated
environmental
risk
factors
in
ADHD,
and
Bisphenol
A
(BPA),
an
endocrine
disruptor,
is
suspected
by
several
reviews.
However,
the
quality
of
has
never
been
carefully
assessed,
leading
us
to
rigorously
examine
associations
between
BPA
exposure
ADHD
associated
symptoms
children.
Using
PRISMA
criteria,
we
conducted
a
systematic
review
on
MEDLINE/PubMed,
Web
Science,
EBSCOhost,
PsycINFO,
PsycARTICLES
Cochrane
databases.
We
used
ROBINS-E
tool
assess
quality,
GRADE
Approach.
This
study
was
registered
with
PROSPERO,
CRD42023377150.
Out
10446
screened
articles,
46
were
included.
Unlike
pre-existing
reviews,
most
failed
find
clear
links
or
symptoms,
high
bias
very
low
level
certainty.
Our
reveals
insufficient
evidence
regarding
impact
despite
some
behavioral
results
that
cannot
be
generalized.
Future
will
require
improved
consideration
confounding
more
precise
sampling
methods.
did
not
receive
specific
funding.
Язык: Английский