Heart Rate Variability and Autonomic Nervous System Imbalance: Potential Biomarkers and Detectable Hallmarks of Aging and Inflammaging

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102521 - 102521

Опубликована: Сен. 1, 2024

Язык: Английский

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Aging and “Age-Related” Diseases - What Is the Relation?

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

The study explores the intricate relationship between aging and development of noncommunicable diseases [NCDs], focusing on whether these are inevitable consequences or primarily driven by lifestyle factors. By examining epidemiological data, particularly from hunter-gatherer societies, highlights that many NCDs prevalent in modern populations rare suggesting a significant influence choices. It delves into mechanisms through which poor diet, smoking, other factors contribute to systemic physiological imbalances, characterized oxidative stress, insulin resistance hyperinsulinemia, dysregulation sympathetic nervous system, renin-angiotensin-aldosterone immune system. interplay this pattern individual such as genetic susceptibility, biological variability, epigenetic changes microbiome is proposed play crucial role range age-related NCDs. Modified biomolecules oxysterols advanced glycation end products also their development. Specific benign prostatic hyperplasia, Parkinson's disease, glaucoma osteoarthritis analyzed illustrate mechanisms. concludes while contributes risk NCDs, role, offering potential avenues for prevention intervention healthier living practices. One possible approach could be try restore balance, e.g. dietary measures [e.g. Mediterranean Okinawan diet Paleolithic diet] conjunction with [a combination of] pharmacological interventions changes.

Язык: Английский

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PM2.5-mediated cardiovascular disease in aging: Cardiometabolic risks, molecular mechanisms and potential interventions

The Science of The Total Environment, Год журнала: 2024, Номер 954, С. 176255 - 176255

Опубликована: Сен. 12, 2024

Язык: Английский

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Similar Patterns of Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue and Post-COVID-19 Syndromes

Pathophysiology, Год журнала: 2024, Номер 31(1), С. 1 - 17

Опубликована: Янв. 5, 2024

Background: There is a considerable overlap between the clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Many their common symptoms can be linked to dysregulation autonomic nervous system (dysautonomia). This study aimed objectively assess function in general group patients with PCC ME/CFS whose disease was not related COVID-19. We hypothesize that similarity chronic extends objective abnormalities. Methods: Synchronous recordings an electrocardiogram continuous dynamics blood pressure digital artery using Penaz method were obtained spiroarteriocardiorhythmography 34 diagnosed ME/CFS, whom onset associated COVID-19, 29 meeting definition 32 healthy controls. Heart rate variability (HRV) systolic diastolic (BPV) assessed at rest tests fixed respiratory rates. Indicators baroreflex regulation (baroreflex effectiveness index sensitivity) additionally determined rest. Results: The total power low-frequency high-frequency RR interval as well sensitivity significantly lower both compared Several diagnostic prediction models for developed based on HRV parameters. During slow breathing, parameters returned normal but patients. correlation analysis revealed close relationship HRV, BPV fatigue, HADS depressive/anxiety Conclusions: A similar pattern failure signs pathological acceleration age-dependent dysautonomia identified clinical, therapeutic implications these findings are discussed, light previously described relationships inflammation, vascular pathology, atherosclerotic cardiovascular dysfunction.

Язык: Английский

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Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 218, С. 111915 - 111915

Опубликована: Фев. 13, 2024

Язык: Английский

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Fermented red pepper paste (kochujang) modulates glucose metabolism and gut microbiota in parasympathetic suppression: Network pharmacology and In vivo study

Food Bioscience, Год журнала: 2024, Номер 61, С. 104531 - 104531

Опубликована: Июнь 16, 2024

Язык: Английский

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Autonomic nervous system imbalance in diabetic mouse choroids

Tissue and Cell, Год журнала: 2025, Номер 94, С. 102798 - 102798

Опубликована: Фев. 13, 2025

Язык: Английский

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Anesthetic sensitivity and resilience in the aging brain: implications for perioperative neurocognitive disorders

Anesthesiology and Perioperative Science, Год журнала: 2025, Номер 3(1)

Опубликована: Март 3, 2025

Язык: Английский

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Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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Altersbedingte Veränderungen des autonomen Nervensystems

DO - Deutsche Zeitschrift für Osteopathie, Год журнала: 2025, Номер 23(02), С. 4 - 10

Опубликована: Март 1, 2025

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