Investigative Ophthalmology & Visual Science,
Год журнала:
2024,
Номер
65(14), С. 41 - 41
Опубликована: Дек. 27, 2024
Purpose:
This
review
explores
the
role
of
pigment
epithelium-derived
factor
(PEDF)
in
retinal
degenerative
and
vascular
disorders
assesses
its
potential
both
as
an
adjunct
to
established
endothelial
growth
inhibiting
treatments
for
diseases
a
neuroprotective
therapeutic
agent.
Methods:
A
comprehensive
literature
was
conducted,
focusing
on
anti-angiogenic
properties
PEDF.
The
evaluated
effects
health,
dysregulation
ocular
disorders,
application
preclinical
models.
Advances
drug
delivery,
including
gene
therapy,
were
also
examined.
Results:
PEDF,
initially
identified
promoting
neuronal
differentiation,
is
potent
endogenous
angiogenesis
inhibitor.
Strong
are
observed
studies.
It
has
pro-apoptotic
antiproliferative
cells
thereby
reducing
neovascularization.
Although
promising,
clinical
development
limited
with
only
single
conducted
phase
I
trial
macular
Development
PEDF-derived
peptides
enhances
potency
specificity,
emerging
therapy
approaches
offer
sustained
PEDF
expression
long-term
treatment.
However,
questions
regarding
dosage,
durability,
efficacy
remain,
particularly
large
animal
Conclusions:
shows
significant
models
degeneration
disorders.
Despite
inconclusive
evidence
downregulation
primary
disease
driver,
many
studies
highlight
benefits
favorable
safety
profile.
could
enable
long-acting
PEDF-based
treatments,
but
further
research
needed
optimize
dosage
potentially
leading
trials
expanding
treatment
options
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Дек. 5, 2024
Abstract
Bioactive
peptides
and
proteins
(BAPPs)
are
promising
therapeutic
agents
for
tissue
repair
with
considerable
advantages,
including
multifunctionality,
specificity,
biocompatibility,
biodegradability.
However,
the
high
complexity
of
microenvironments
their
inherent
deficiencies
such
as
short
half-live
susceptibility
to
enzymatic
degradation,
adversely
affect
efficacy
clinical
applications.
Investigating
fundamental
mechanisms
by
which
BAPPs
modulate
microenvironment
developing
rational
delivery
strategies
essential
optimizing
administration
in
distinct
repairs
facilitating
translation.
This
review
initially
focuses
on
through
influence
via
reactive
oxygen
species,
blood
lymphatic
vessels,
immune
cells,
cells.
Then,
a
variety
platforms,
scaffolds
hydrogels,
electrospun
fibers,
surface
coatings,
assisted
particles,
nanotubes,
two-dimensional
nanomaterials,
nanoparticles
engineered
summarized
incorporate
effective
repair,
modification
aimed
at
enhancing
loading
efficiencies
release
kinetics
also
reviewed.
Additionally,
can
be
precisely
regulated
endogenous
stimuli
(glucose,
enzymes,
pH)
or
exogenous
(ultrasound,
heat,
light,
magnetic
field,
electric
field)
achieve
on-demand
tailored
specific
needs.
Furthermore,
this
potential
across
various
types,
bone,
cartilage,
intervertebral
discs,
muscle,
tendons,
periodontal
tissues,
skin,
myocardium,
nervous
system
(encompassing
brain,
spinal
cord,
peripheral
nerve),
endometrium,
well
ear
ocular
tissue.
Finally,
current
challenges
prospects
discussed.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Ferroptosis,
a
new
type
of
programmed
cell
death
proposed
in
recent
years,
is
characterized
mainly
by
reactive
oxygen
species
and
iron-mediated
lipid
peroxidation
differs
from
death,
such
as
apoptosis,
necrosis,
autophagy.
Ferroptosis
associated
with
variety
physiological
pathophysiological
processes.
Recent
studies
have
shown
that
ferroptosis
can
aggravate
or
reduce
the
occurrence
development
diseases
targeting
metabolic
pathways
signaling
tumors,
ischemic
organ
damage,
other
degenerative
related
to
peroxidation.
Increasing
evidence
suggests
closely
linked
onset
progression
various
ophthalmic
conditions,
including
corneal
injury,
glaucoma,
age-related
macular
degeneration,
diabetic
retinopathy,
retinal
detachment,
retinoblastoma.
Our
review
current
research
on
reveals
significant
advancements
our
understanding
pathogenesis,
aetiology,
treatment
these
conditions.
Ophthalmic Plastic and Reconstructive Surgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
To
test
a
novel
early
polytherapy
treatment
strategy
targeting
mitochondrial
bioenergetics,
glutamate
excitotoxicity,
and
sterile
inflammatory
response
molecular
pathways
associated
with
retinal
ganglion
cell
survival
following
optic
nerve
trauma.
Twenty
C57BL/6J
mice
were
subjected
to
sonication-induced
traumatic
neuropathy
injury.
The
control
group
(n
=
10)
received
intravitreal,
retrobulbar,
subcutaneous
phosphate
buffered
saline
injections
on
days
0
3
(no
repeat
retrobulbar
vehicle).
On
day
0,
the
of
intravitreal
interleukin-1
receptor
antagonist
ketamine,
ropivacaine,
etanercept.
Treatment
animals
had
1%
(wt/vol)
N-acetylcysteine
ad
libitum
supplemented
in
drinking
water
from
1.
3,
pan-ephrin
peptide
elamipretide
etanercept
given.
Pattern
electroretinogram
assessments
continued
at
weeks
1,
2,
4,
6,
8,
10,
12.
Optical
coherence
tomography
layer
thickness
was
measured
naive,
control,
groups
week
whole
mount
retinas
harvested
for
quantitation.
At
12
weeks,
averaged
density
count
lower
(413.37
±
41.77
cells/mm2)
compared
(553.97
18.00
cells/mm2;
p
<
0.001)
naive
(595.94
30.67cells/mm2;
groups.
Ganglion
complex
thicknesses
showed
(49.29
5.48
μm)
thinner
than
treated
(61.00
2.57
μm;
0.004)
(67.00
6.12
No
significant
difference
seen
between
recordings
revealed
statistically
decrease
amplitudes
all
time
points.
Apart
did
not
significantly
differ
baseline
any
point.
Early
combinatorial
therapeutic
intervention
address
disparate
trauma
effectively
halts
neurons'
progressive
structural
functional
degeneration.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2334 - 2334
Опубликована: Март 5, 2025
Oxidative
stress-induced
photoreceptor
cell
death
is
closely
associated
with
the
etiology
of
age-related
macular
degeneration
(AMD),
and
sodium
iodate
(SI)
has
been
widely
used
as
an
oxidant
stimulus
in
AMD
models
to
induce
retinal
pigment
epithelium
(RPE)
death.
However,
mechanism
underlying
SI-induced
remains
controversial
unclear.
In
this
study,
we
elucidate
that
ferroptosis
a
critical
form
induced
by
SI
photoreceptor-derived
661W
cells.
disrupts
system
Xc-,
leading
glutathione
(GSH)
depletion
triggering
lipid
peroxidation,
thereby
promoting
Additionally,
enhances
intracellular
Fe2+
levels,
which
further
facilitates
reactive
oxygen
species
(ROS)
accumulation,
making
cells
more
susceptible
ferroptosis.
Exogenous
GSH,
well
specific
inhibitors
such
Fer-1
antioxidants
like
NAC,
significantly
attenuate
These
findings
provide
new
insights
into
mechanisms
key
pathway
Free Radical Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Март 5, 2025
The
purpose
of
this
study
is
to
investigate
FABP3's
biological
function
and
potential
mechanism
in
cataract.
Treatment
H2O2
raised
FABP3
expression.
decreased
cell
viability,
enhanced
apoptosis,
promoted
Bax
cleaved
caspase-3
expression,
inhibited
Bcl-2
the
levels
IL-6,
IL-1β,
TNF-α,
MDA
level,
SOD
GSH
HLE-B3
cells.
However,
effects
on
inflammatory
cytokines,
oxidative
stress
were
reversed
by
knockdown
aggravated
overexpression.
increased
lipid
hydroperoxides
Fe2+,
but
reduced
expression
GPX4,
SLC7A11,
Ferritin
protein.
Nevertheless,
changes
hydroperoxides,
protein,
overexpression
caused
opposite
results.
In
addition,
inhibition
inflammation,
was
ferroptosis
inducer
(erastin),
promotion
inhibitor
(Fer-1).
Taken
together,
lens
epithelial
cells
treated
with
restrained
through
regulating
ferroptosis,
suggesting
that
might
be
a
target
for
cataract
treatment.
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Апрель 2, 2025
Sodium
fluoride-induced
ocular
damage
constitutes
a
significant
public
health
concern
globally;
however,
the
precise
molecular
mechanisms
underlying
this
issue
remain
obscure.
This
study
aims
to
investigate
effects
of
sodium
fluoride
on
myopia
and
offer
novel
theoretical
foundations
for
future
strategies
in
prevention
control.
The
experimental
data
showed
that
could
promote
progression,
through
bioinformatics
analysis,
we
found
affect
ferroptosis
pathway.
Western
blotting
redox
kit
assays
further
confirmed
activates
We
also
demonstrated
PIEZO1
plays
crucial
role
myopia,
inhibitor
(GsMTx4)
can
inhibit
Subsequently,
identified
as
potential
target
baicalin,
which
inhibited
expression
vivo
vitro,
by
docking
modeling
CETSA
assays.
Finally,
baicalin
via
PIEZO1.
Taken
together,
our
findings
indicate
progression
activating
pathway
PIEZO1,
targeting
delay
may
provide
new
drug
treatment
future.
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 986 - 986
Опубликована: Апрель 17, 2025
Iron
homeostasis
plays
an
important
role
in
maintaining
cellular
homeostasis;
however,
excessive
iron
can
promote
the
production
of
reactive
oxygen
species
(ROS).
Ferroptosis
is
iron-dependent
programmed
cell
death
that
characterized
by
accumulation,
elevated
lipid
peroxides,
and
overproduction
ROS.
The
maintenance
contingent
upon
activity
transferrin
receptor
(TfR),
ferritin
(Ft),
ferroportin
(FPn).
In
retina,
accumulation
peroxidation
contribute
to
development
age-related
macular
degeneration
(AMD).
This
phenomenon
be
explained
occurrence
Fenton
reaction,
which
interaction
between
divalent
hydrogen
peroxide
leads
generation
highly
hydroxyl
radicals.
radicals
exhibit
a
propensity
attack
proteins,
lipids,
nucleic
acids,
carbohydrates,
thereby
instigating
oxidative
damage
promoting
peroxidation.
Ultimately,
these
processes
culminate
retinal
degeneration.
this
context,
comprehensive
understanding
exact
mechanisms
underlying
ferroptosis
may
hold
significant
importance
for
developing
therapeutic
interventions.
review
summarizes
recent
findings
on
metabolism,
ferroptosis,
metabolism
aging
retina.
We
also
introduce
developments
strategies
using
chelating
agents.
Further
refinements
knowledges
would
deepen
our
comprehension
pathophysiology
AMD
advance
clinical
management
degenerative
retinopathy.
A
search
strategy
was
employed
identify
relevant
studies
AMD.
performed
systematic
searches
PubMed
Web
Science
electronic
databases
from
inception
current
date.
keywords
used
included
“ferroptosis”,
“AMD”,
“age-related
degeneration”,
“iron
metabolism”,
“oxidative
stress”,
“ferroptosis
pathways”.
Peer-reviewed
articles,
including
original
research,
reviews,
meta-analyses,
studies,
were
paper,
with
focus
molecular
AMDs.
Studies
not
directly
related
or
stress
context
excluded.
Furthermore,
articles
lacked
sufficient
data
peer-reviewed
(e.g.,
conference
abstracts,
editorials,
opinion
pieces)
considered.
