The role of purpose in life in healthy aging: implications for the Semmelweis Study and the Semmelweis-EUniWell Workplace Health Promotion Model Program
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 29, 2025
The
global
aging
population
presents
significant
challenges
to
public
health
systems,
particularly
in
countries
like
Hungary,
which
faces
some
of
the
least
favorable
indicators
European
Union.
To
address
these
challenges,
Purpose
Life
(PIL)
has
emerged
as
a
critical
determinant
healthy
aging,
influencing
physical,
mental,
and
social
health.
Defined
sense
meaning,
direction,
intentionality,
PIL
promotes
resilience,
mitigates
age-related
decline,
fosters
well-being.
This
review
explores
theoretical
frameworks,
mechanisms,
practical
implications
context
aging.
Biologically,
regulates
stress
responses,
contributing
reduced
disease
risk
improved
longevity.
Psychologically,
self-regulation,
positive
emotions,
buffer
against
mental
support
cognitive
Socially,
strengthens
meaningful
relationships,
prosocial
behaviors,
collective
purpose,
reducing
isolation
enhancing
cohesion.
These
mechanisms
interact
create
synergistic
effect
that
supports
trajectories.
Semmelweis
Study,
Hungary's
most
extensive
workplace
cohort
study,
offers
unique
opportunity
integrate
assessment
into
its
longitudinal
design,
providing
novel
insights
how
influences
outcomes.
Complementing
this
research,
Semmelweis-EUniWell
Workplace
Health
Promotion
Program
translates
actionable
interventions,
designed
enhance
employee
well-being
productivity.
Drawing
from
best
practices,
including
Blue
Zones
Mediterranean-inspired
Hungary
can
position
cornerstone
agenda.
Incorporating
PIL-focused
strategies
programs
national
policies
holds
potential
extend
healthspan,
reduce
healthcare
costs,
foster
resilient
purposeful
population.
highlights
transformative
addressing
multifaceted
advancing
goals.
Язык: Английский
Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Sleep
disorders,
particularly
insomnia
and
obstructive
sleep
apnea,
are
increasingly
implicated
as
significant
contributors
to
cognitive
decline,
dementia,
neurodegenerative
diseases
such
Alzheimer’s
disease
(AD)
vascular
impairment
dementia
(VCID).
However,
the
extent
specificity
of
these
associations
remain
uncertain.
This
meta-analysis
evaluates
impact
common
disorders
on
risk
developing
decline.
A
comprehensive
search
literature
was
conducted
identify
prospective
cohort
studies
assessing
risk.
Studies
reporting
estimates
for
AD,
or
decline
associated
with
insomnia,
other
(e.g.,
restless
legs
syndrome,
circadian
rhythm
excessive
daytime
sleepiness)
were
included.
Meta-analyses
performed
using
a
random-effects
model
calculate
pooled
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs).
Thirty-nine
included,
subgroup
analyses
showing
between
all-cause
apnea
(HR
1.33,
CI
1.09–1.61),
1.36,
1.19–1.55),
1.24–1.43).
Obstructive
increased
AD
1.45,
1.24–1.69),
though
its
association
did
not
reach
statistical
significance
1.35,
0.99–1.84).
Insomnia
significantly
both
1.59,
1.01–2.51)
1.49,
1.27–1.74).
highlights
critical
role
in
risk,
emphasizing
need
early
detection
management
disturbances.
Targeted
interventions
could
play
pivotal
reducing
among
high-risk
populations.
Язык: Английский