As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies DOI
Jiangao Li,

Niu Niu,

Deliang Wang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 137(1)

Опубликована: Сен. 21, 2024

Abstract Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near‐infrared (NIR‐II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation‐induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation‐locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic‐shifts wavelength centered NIR‐II region. Meanwhile, AIE tendency mainly originated from flexibly propeller‐like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal‐chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Язык: Английский

The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer DOI
Caifa You,

Leyuan Tian,

Jun Zhu

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(2), С. 2010 - 2020

Опубликована: Янв. 7, 2025

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance excited states energy dissipations. In this study, a multifunctional iridium(III) complex exploited by coordination AIE-active N^N ancillary ligand trivalent iridium ion. The resultant DPTPzIr significantly outperforms its parent terms absorption/emission wavelengths, reactive oxygen species (ROS) production, photothermal conversion, which simultaneously endow nanoparticles matched absorption peak to commercial 808 nm laser, longest NIR-II (above 1100 nm) among those previously reported AIE complexes, potentiated type-I ROS generation, as high 60.5% conversion efficiency. Consequently, perform well multimodal image-guided photodynamic therapy-photothermal breast tumor-bearing mice, enabling precise tumor diagnosis complete ablation biocompatibility. Our present work provides simple, feasible, effective paradigm development advanced agents.

Язык: Английский

Процитировано

6
As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies DOI
Jiangao Li,

Niu Niu,

Deliang Wang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)

Опубликована: Сен. 21, 2024

Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near-infrared (NIR-II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation-induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation-locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic-shifts wavelength centered NIR-II region. Meanwhile, AIE tendency mainly originated from flexibly propeller-like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence-photoacoustic-photothermal trimodal imaging-guided photothermal-chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Язык: Английский

Процитировано

8
Harnessing donor cyclization strategy: Converting type II to type I photosensitizers and enhancing AIE performance for NIR-II FL/MR imaging-guided photodynamic therapy under hypoxia condition DOI

Chonglu Li,

Jie Li,

Yida Pang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 155471 - 155471

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4
Molecular fluorination strategy for regulating NIR AIEgens to boost phototheranostics of nasopharyngeal carcinoma DOI
Ping Zheng,

Yuxun Ding,

Alim Abdurahman

и другие.

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0
A Spiro‐Based NIR‐II Photosensitizer with Efficient ROS Generation and Thermal Conversion Performances for Imaging‐Guided Tumor Theranostics DOI Open Access

Y. W. Jin,

Kang Xu, Baoyi Ren

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Organic photosensitizers (PSs) possessing NIR‐II emission and photodynamic/photothermal effect have received a great sense of attention for their cutting‐edge applications in imaging‐guided multimodal phototherapy. However, it is highly challenging to design efficient PSs with high luminescence phototherapy performance simultaneously. In this study, spiro‐functionalization strategy proposed alleviate aggregate‐caused quenching promote photodynamic therapy, the verified via spiro[fluorine‐9,9ʹ‐xanthene]‐modified PS (named SFX‐IC) an acceptor–donor–acceptor configuration. SFX‐IC‐based nanoparticles (NPs) display molar extinction coefficient 7.05 × 10 4 m ‒1 cm −1 at 645 nm due strong intramolecular charge‐transfer characteristics. As expected, as‐prepared NPs show fluorescence quantum yield 1.1%, thanks spiro‐configuration that suppressing excessively intermolecular π–π stacking. Furthermore, SFX‐IC not only efficiently generate 1 O 2 ∙− under 660 laser irradiation, but also possess good photothermal conversion efficiency 47.14%. Consequently, can be served as versatile phototheranostic agents fluorescence/photoacoustic phototherapy, manifesting spiro‐functionalized powerful tool construct emitting PSs.

Язык: Английский

Процитировано

0
Recent Progress of Molecular Design in Organic Type I Photosensitizers DOI
Tao Xiong, Yingchao Chen, Mingle Li

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Photodynamic therapy (PDT) represents a high‐efficient and non‐invasive therapeutic modality for current future tumor treatments, drawing extensive attention in the fields of antitumor drug clinical phototherapy. In recent years, photosensitizer (PS) market PDT applications have expanded to address various cancers skin diseases. However, hypoxic environment within tumors poses substantial challenge capability reactive oxygen species‐dependent PDT. Consequently, researches increasingly focus from type II I mechanism, which relies on radical production with less or no dependence. Despite significant progress development PSs, holistic understanding regarding design principles these molecules remains elusive. Specifically, electron transfer‐mediated are extensively studied years but is insufficiently addressed existing reviews. This review systematically summarizes advancements molecular rationales organic categorizing them into three key fundamental strategies: modulating PS charge distribution, singlet forbidden via low triplet excited state, accelerating formation inducing transfer. aims offer valuable insights advancement anti‐hypoxia

Язык: Английский

Процитировано

0
Optimizing energy transfer in NIR ruthenium(II) complexes to enhance stability and efficiency in sonodynamic therapy DOI Creative Commons

Dazhuang Xu,

Qixuan Dai,

Jian Sun

и другие.

Ultrasonics Sonochemistry, Год журнала: 2025, Номер unknown, С. 107415 - 107415

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies DOI
Jiangao Li,

Niu Niu,

Deliang Wang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 137(1)

Опубликована: Сен. 21, 2024

Abstract Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near‐infrared (NIR‐II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation‐induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation‐locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic‐shifts wavelength centered NIR‐II region. Meanwhile, AIE tendency mainly originated from flexibly propeller‐like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal‐chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Язык: Английский

Процитировано

0