Multisubstituted Indoles by a Dual Gold/Silver-Catalyzed Aminoalkynylation of 2-Alkynylanilines DOI
Peng Shen, Huanjun Zhang, Dan Xiao

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

A straightforward and efficient method for the synthesis of multisubstituted indoles has been developed through a dual gold/silver-catalyzed aminoalkynylation 2-alkynylanilines using hypervalent iodine(III) reagents under open-air conditions. This approach features in situ generation alkynyl Au(III) species, which facilitates with excellent functional group tolerance high yields. Mechanistic studies reveal that gold(III) intermediate plays crucial role reaction pathway. Moreover, protocol is scalable to gram quantities offers potential further transformation into diverse functionalized compounds.

Язык: Английский

Gold-catalyzed selective modification of peptides: synthesis of cyclic and acyclic peptide derivatives DOI
Guozhi Zhao,

Chengjie Guo,

Dongping Wang

и другие.

Gold bulletin, Год журнала: 2025, Номер 58(1)

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

0
Multisubstituted Indoles by a Dual Gold/Silver-Catalyzed Aminoalkynylation of 2-Alkynylanilines DOI
Peng Shen, Huanjun Zhang, Dan Xiao

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

A straightforward and efficient method for the synthesis of multisubstituted indoles has been developed through a dual gold/silver-catalyzed aminoalkynylation 2-alkynylanilines using hypervalent iodine(III) reagents under open-air conditions. This approach features in situ generation alkynyl Au(III) species, which facilitates with excellent functional group tolerance high yields. Mechanistic studies reveal that gold(III) intermediate plays crucial role reaction pathway. Moreover, protocol is scalable to gram quantities offers potential further transformation into diverse functionalized compounds.

Язык: Английский

Процитировано

0