Multisubstituted Indoles by a Dual Gold/Silver-Catalyzed Aminoalkynylation of 2-Alkynylanilines DOI
Peng Shen, Huanjun Zhang, Dan Xiao

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

A straightforward and efficient method for the synthesis of multisubstituted indoles has been developed through a dual gold/silver-catalyzed aminoalkynylation 2-alkynylanilines using hypervalent iodine(III) reagents under open-air conditions. This approach features in situ generation alkynyl Au(III) species, which facilitates with excellent functional group tolerance high yields. Mechanistic studies reveal that gold(III) intermediate plays crucial role reaction pathway. Moreover, protocol is scalable to gram quantities offers potential further transformation into diverse functionalized compounds.

Language: Английский

Gold-catalyzed selective modification of peptides: synthesis of cyclic and acyclic peptide derivatives DOI
Guozhi Zhao,

Chengjie Guo,

Dongping Wang

et al.

Gold bulletin, Journal Year: 2025, Volume and Issue: 58(1)

Published: March 20, 2025

Language: Английский

Citations

0
Multisubstituted Indoles by a Dual Gold/Silver-Catalyzed Aminoalkynylation of 2-Alkynylanilines DOI
Peng Shen, Huanjun Zhang, Dan Xiao

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

A straightforward and efficient method for the synthesis of multisubstituted indoles has been developed through a dual gold/silver-catalyzed aminoalkynylation 2-alkynylanilines using hypervalent iodine(III) reagents under open-air conditions. This approach features in situ generation alkynyl Au(III) species, which facilitates with excellent functional group tolerance high yields. Mechanistic studies reveal that gold(III) intermediate plays crucial role reaction pathway. Moreover, protocol is scalable to gram quantities offers potential further transformation into diverse functionalized compounds.

Language: Английский

Citations

0