Tuning Exciton Coupling of Non-Conjugated Cyanine Dimers for Efficient Photodynamic Immunotherapy DOI
Hua Gu, P. Yuan, Juan Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Cyanine dyes usually serve as good fluorescence probes but not efficient photosensitizers owing to the spin-forbidden intersystem crossing process and short excited-state lifetime. Nevertheless, structure-derived energy release from excited state could enable function efficiently. In this work, we developed cyanine dimers (2o-Cy, 2m-Cy, 2p-Cy) based on exciton coupling effects by connecting two Cy5.5 molecules at N-indole site with nonconjugated ortho/meta/para-bis(bromomethyl)benzene linkers. These exhibited significantly enhanced molar extinction coefficients (32-45 × 104 M cm-1) well satisfactory triplet quantum yields (32-44%) lifetimes (10.6-11.9 μs), leading a substantially reactive oxygen species production along antitumor activity under both normoxic hypoxic conditions. Furthermore, 2p-Cy NPs ablated primary tumors, inhibited distant tumor growth, prevented metastatic regrowth via photoinduced innate immune activation. This dimer-based strategy represents powerful approach develop high-performance photosensitive for photodynamic immunotherapy.

Language: Английский

Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics DOI
Shiping Yang, Qian Jia, Xinwen Ou

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

Citations

7

A new nanomaterial - carbonized polymer dots and their applications: A review DOI
Xiaoyu Li,

Chunyuan Kang,

Songyuan Tao

et al.

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 120122 - 120122

Published: Feb. 1, 2025

Language: Английский

Citations

4

Unlocking the potential of iridium-osmium carbolong conjugates: a high-performance photocatalyst for melanoma therapy DOI
Haobing Wang, Rongfang Wang, Shiyan Chen

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

1

Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity DOI Creative Commons
Weidong Xiao,

Mingquan Gao,

Banghui Mo

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 491 - 491

Published: March 28, 2025

Background: Endoplasmic reticulum (ER)-targeted phototherapy has emerged as a promising approach to amplify ER stress, induce immunogenic cell death (ICD), and enhance anti-tumor immunity. However, its impact on the antigenicity of dying tumor cells remains poorly understood. Methods: Laser activation ER-targeted photosensitizer ER-Cy-poNO2 was performed investigate effects antigenicity. Transcriptomic analysis carried out assess gene expression changes. Immunopeptidomics profiling used identify high-affinity major histocompatibility complex class I (MHC-I) ligands. In vitro functional studies were conducted evaluate dendritic maturation T lymphocyte activation, while in vivo experiments by combining identified peptide with poly IC Results: significantly remodeled antigenic landscape 4T-1 cells, enhancing their immunogenicity. revealed upregulation antigen processing presentation pathways. multiple MHC-I ligands, IF4G3986–994 (QGPKTIEQI) showing exceptional vitro, promoted enhanced lymphocytes activation. vivo, combination elicited robust immunity, characterized increased CD8+ infiltration, reduced regulatory (Tregs) microenvironment, elevated systemic Interferon-gamma (IFN-γ) levels, significant growth inhibition without toxicity. Conclusions: These findings establish mechanistic link between stress-driven ICD, immunopeptidome remodeling, adaptive immune highlighting potential platform for identifying peptides advancing peptide-based cancer vaccines.

Language: Английский

Citations

1

Expanding the Horizons of Phototherapy: A Review on the Superior Performance of Chalcogen‐Based Photosensitizers and Photothermal Agents for Cancer Therapy DOI Creative Commons
Subhrakant Jena,

Pranay Mohanty,

L. K. Dash

et al.

ChemPhotoChem, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Phototherapy, encompassing photodynamic therapy (PDT) and photothermal (PTT), presents a promising cancer treatment strategy with high spatial specificity minimal invasiveness. Optimizing these techniques hinges on the design of high‐performance photosensitizers (PSs) agents (PTAs). Single‐atom chalcogen substitution, at both endocyclic exocyclic positions in conventional organic chromophores, has proven to be novel for enhancing their photophysical photochemical properties. Ideal PSs/PTAs exhibit biocompatibility, visible‐to‐near‐infrared (vis–NIR) absorption, efficient triplet state harvesting, feasible heat energy transfer efficiency. Moreover, chalcogen‐based show promise synergistic multimodal therapies, integrating imaging treatment. This review comprehensively examines recent advancements (within last five years) utilizing substitution robust PDT/PTT. It provides holistic perspective spectroscopic characterization computational analyses, singlet‐oxygen/triplet quantum yields, generation efficiency, vitro/in vivo biological evaluations chalcogen‐substituted PSs/PTAs. is anticipated that this will stimulate further research endeavors area.

Language: Английский

Citations

1

Molecular fluorination strategy for regulating NIR AIEgens to boost phototheranostics of nasopharyngeal carcinoma DOI
Ping Zheng,

Yuxun Ding,

Alim Abdurahman

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0

Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy DOI Creative Commons

Yangtian Ye,

Shaojing Zhao,

E Pang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a significant challenge. Herein, we optimally selected the molecule IT-4F an acceptor-donor-acceptor (A-D-A) structure prepare water-dispersible nanoparticles (NPs) by assembly DSPE-PEG-NH2. Such NPs have NIR absorption fluorescence peaks at 728 817 nm, respectively. They can singlet (1O2) superoxide anion (O2-·) irradiation, 1O2 generation quantum yield 31.5%. also effectively convert photon-energy into heat PCE 42.8%. outstanding properties enable them be used in imaging guided therapy (PTT), photodynamic (PDT). Moreover, PDT PTT triggered immunogenic cell death PANoptosis tumor cells, which not only inhibited growth metastasis mice model, but induced robust immune response, evidenced increased infiltration CD8+ T CD4+ dendritic decreased presence immunosuppressive cells such as myeloid-derived suppressor regulatory cells. efficacy organoid human breast cancer was verified.

Language: Английский

Citations

0

Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy DOI

Shaoqi Xie,

Chang Liu,

Yue Cao

et al.

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0

Rational design and self-assembly of amphiphilic conjugated porphyrin small molecules for PDT/PTT synergistic therapy DOI

Binyu Zhao,

Haolan Li,

Cheng Li

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142002 - 142002

Published: March 1, 2025

Language: Английский

Citations

0

Mesoporous bowl-shaped polydopamine co-loaded temozolomide and indocyanine green for synergistically inhibiting glioblastoma DOI
Guangwei Zheng, Lei Ding,

Jingzheng Gan

et al.

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0