Multiple functions of the herpesvirus UL14 gene product in viral infection DOI Creative Commons

Jieyu Wan,

Mingshu Wang, Anchun Cheng

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Окт. 23, 2024

Herpesviruses are a family of double-stranded DNA viruses with tegument structure and genome composed single sequence terminal repeat (TR) sequences. The herpesvirus UL14 gene encodes the protein (pUL14), which has various subcellular localizations plays vital role in regulating immediate-early (IE) transcription expression, influences intracellular localization patterns several proteins belonging to capsid packaging machinery, participates secondary envelopment, viral particle release. Additionally, pUL14 roles maintaining cellular homeostasis preventing apoptosis. This review discusses how engages life cycle herpesviruses provides new ideas for further research on pUL14's function infection.

Язык: Английский

The novel lncRNA-9802/miR-1646 axis affects cell proliferation of DF-1 by regulating Bax/Bcl-2 signaling pathway DOI

Shuo Han,

Shuang Zhao, Yaolu Zhao

и другие.

Research in Veterinary Science, Год журнала: 2023, Номер 164, С. 105047 - 105047

Опубликована: Окт. 12, 2023

Язык: Английский

Процитировано

2

LORF9 of Marek’s disease virus is involved in the early cytolytic replication of B lymphocytes and can act as a target for gene deletion vaccine development DOI
Xiaojing Zhu,

Lele Wang,

Lele Gong

и другие.

Journal of Virology, Год журнала: 2023, Номер 97(12)

Опубликована: Ноя. 28, 2023

ABSTRACT Marek’s disease (MD) is a poultry characterized by severe immunosuppression and the development of T cell lymphomas caused virus (MDV). Our study focuses on role viral LORF9 gene in MD pathogenesis vaccine development. We found that deletion mutant (Md5BAC Δ ) showed significantly reduced pathogenicity compared with parental strain. The essential for early cytolytic infection B cells. Interestingly, Md5BAC provided adequate immunological protection against very virulent MDV challenge induced distinct host immune response CVI988/Rispens Transcriptome analysis revealed led to different expression innate immunity-associated genes. Overall, our provides insights into highlights its importance IMPORTANCE (MDV) highly infectious oncogenic can induce chickens. encodes more than 100 genes, most which have unknown functions. This work indicated necessary replication lymphocytes. In addition, we has comparative protective effect strain challenge. significant discovery be exploited as possible target an vaccine.

Язык: Английский

Процитировано

2

CRISPR-cas technology and use in antiviral development DOI Open Access
Zeynep Yolhan Şeflek, Mustafa Hasöksüz

Journal of Istanbul Veterinary Sciences, Год журнала: 2024, Номер 8(2), С. 195 - 206

Опубликована: Авг. 31, 2024

Throughout history, viral diseases have periodically reached pandemic proportions and had devastating effects on human history. With the advancement of science technology, antivirals been developed continue to be in fight against diseases. The difficulty development antirival has tried use new technologies antiviral. One these is CRISPR/Cas system. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) defines a series DNA sequences called clusters regularly interspaced palindromic repeats, CAS endonucleases that as guide recognize cut specific chains related region. While protein engineering systems defined before can off-target cause undesirable results, system reduces this risk by Watson-Crick base pairing. In infections humans animals, vaccine protection methods are widely used due problems developing antivirals. On other hand, vaccination, inadequacies long-term immunity emergence or epidemics mutational changes viruses pave way for This article emphasizes history working areas CRISPR-Cas technology potential applications method antiviral animal

Язык: Английский

Процитировано

0

Multiple functions of the herpesvirus UL14 gene product in viral infection DOI Creative Commons

Jieyu Wan,

Mingshu Wang, Anchun Cheng

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Окт. 23, 2024

Herpesviruses are a family of double-stranded DNA viruses with tegument structure and genome composed single sequence terminal repeat (TR) sequences. The herpesvirus UL14 gene encodes the protein (pUL14), which has various subcellular localizations plays vital role in regulating immediate-early (IE) transcription expression, influences intracellular localization patterns several proteins belonging to capsid packaging machinery, participates secondary envelopment, viral particle release. Additionally, pUL14 roles maintaining cellular homeostasis preventing apoptosis. This review discusses how engages life cycle herpesviruses provides new ideas for further research on pUL14's function infection.

Язык: Английский

Процитировано

0