Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 23, 2024
Herpesviruses
are
a
family
of
double-stranded
DNA
viruses
with
tegument
structure
and
genome
composed
single
sequence
terminal
repeat
(TR)
sequences.
The
herpesvirus
UL14
gene
encodes
the
protein
(pUL14),
which
has
various
subcellular
localizations
plays
vital
role
in
regulating
immediate-early
(IE)
transcription
expression,
influences
intracellular
localization
patterns
several
proteins
belonging
to
capsid
packaging
machinery,
participates
secondary
envelopment,
viral
particle
release.
Additionally,
pUL14
roles
maintaining
cellular
homeostasis
preventing
apoptosis.
This
review
discusses
how
engages
life
cycle
herpesviruses
provides
new
ideas
for
further
research
on
pUL14's
function
infection.
Journal of Virology,
Год журнала:
2023,
Номер
97(12)
Опубликована: Ноя. 28, 2023
ABSTRACT
Marek’s
disease
(MD)
is
a
poultry
characterized
by
severe
immunosuppression
and
the
development
of
T
cell
lymphomas
caused
virus
(MDV).
Our
study
focuses
on
role
viral
LORF9
gene
in
MD
pathogenesis
vaccine
development.
We
found
that
deletion
mutant
(Md5BAC
Δ
)
showed
significantly
reduced
pathogenicity
compared
with
parental
strain.
The
essential
for
early
cytolytic
infection
B
cells.
Interestingly,
Md5BAC
provided
adequate
immunological
protection
against
very
virulent
MDV
challenge
induced
distinct
host
immune
response
CVI988/Rispens
Transcriptome
analysis
revealed
led
to
different
expression
innate
immunity-associated
genes.
Overall,
our
provides
insights
into
highlights
its
importance
IMPORTANCE
(MDV)
highly
infectious
oncogenic
can
induce
chickens.
encodes
more
than
100
genes,
most
which
have
unknown
functions.
This
work
indicated
necessary
replication
lymphocytes.
In
addition,
we
has
comparative
protective
effect
strain
challenge.
significant
discovery
be
exploited
as
possible
target
an
vaccine.
Journal of Istanbul Veterinary Sciences,
Год журнала:
2024,
Номер
8(2), С. 195 - 206
Опубликована: Авг. 31, 2024
Throughout
history,
viral
diseases
have
periodically
reached
pandemic
proportions
and
had
devastating
effects
on
human
history.
With
the
advancement
of
science
technology,
antivirals
been
developed
continue
to
be
in
fight
against
diseases.
The
difficulty
development
antirival
has
tried
use
new
technologies
antiviral.
One
these
is
CRISPR/Cas
system.
CRISPR
(Clustered
Regularly
Interspaced
Short
Palindromic
Repeats)
defines
a
series
DNA
sequences
called
clusters
regularly
interspaced
palindromic
repeats,
CAS
endonucleases
that
as
guide
recognize
cut
specific
chains
related
region.
While
protein
engineering
systems
defined
before
can
off-target
cause
undesirable
results,
system
reduces
this
risk
by
Watson-Crick
base
pairing.
In
infections
humans
animals,
vaccine
protection
methods
are
widely
used
due
problems
developing
antivirals.
On
other
hand,
vaccination,
inadequacies
long-term
immunity
emergence
or
epidemics
mutational
changes
viruses
pave
way
for
This
article
emphasizes
history
working
areas
CRISPR-Cas
technology
potential
applications
method
antiviral
animal
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 23, 2024
Herpesviruses
are
a
family
of
double-stranded
DNA
viruses
with
tegument
structure
and
genome
composed
single
sequence
terminal
repeat
(TR)
sequences.
The
herpesvirus
UL14
gene
encodes
the
protein
(pUL14),
which
has
various
subcellular
localizations
plays
vital
role
in
regulating
immediate-early
(IE)
transcription
expression,
influences
intracellular
localization
patterns
several
proteins
belonging
to
capsid
packaging
machinery,
participates
secondary
envelopment,
viral
particle
release.
Additionally,
pUL14
roles
maintaining
cellular
homeostasis
preventing
apoptosis.
This
review
discusses
how
engages
life
cycle
herpesviruses
provides
new
ideas
for
further
research
on
pUL14's
function
infection.
