Inorganics,
Год журнала:
2024,
Номер
12(12), С. 325 - 325
Опубликована: Дек. 13, 2024
Bromelain
(Br)
is
a
proteolytic
enzyme
with
various
pharmacological
properties,
such
as
antibacterial,
antioxidant,
anti-inflammatory,
anticancer,
and
anti-angiogenic
properties.
However,
due
to
its
low
solubility
bioavailability,
absorption
low,
so
delivery
mechanism
needed
achieve
the
desired
therapeutic
effects.
was
chemically
synthesized
loaded
onto
gold
nanoparticles
(AuNPs).
Different
methods
techniques
were
used
for
detection
characterization,
including
color-change
detection,
UV
spectroscopy,
XRD,
SEM,
TEM,
FTIR.
The
in
vitro
antioxidant
activity
detected
using
DPPH
assays,
wound-healing
investigated
mice.
current
study
revealed
that
formulated
AuNPs-Br
showed
effective
strongest
demonstrated
by
histopathological
vivo
studies,
ACS Omega,
Год журнала:
2024,
Номер
9(40), С. 41107 - 41129
Опубликована: Сен. 16, 2024
This
review
examines
the
convergence
of
silver
nanoparticles
(AgNPs),
three-dimensional
(3D)
printing,
and
wound
healing,
focusing
on
significant
advancements
in
these
fields.
We
explore
unique
properties
AgNPs,
notably
their
strong
antibacterial
efficacy
potential
applications
enhancing
recovery.
Furthermore,
delves
into
3D
printing
technology,
discussing
its
core
principles,
various
materials
employed,
recent
innovations.
The
integration
AgNPs
3D-printed
structures
for
regenerative
medicine
is
analyzed,
emphasizing
benefits
this
combined
approach
identifying
challenges
that
must
be
addressed.
comprehensive
overview
aims
to
elucidate
current
state
field
direct
future
research
toward
developing
more
effective
solutions
healing.
Nanotechnology Reviews,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
The
current
study
proposed
a
novel
simple
and
environmentally
friendly
approach
for
producing
silver
nanoparticles
(AgNPs)
using
an
extract
of
Moringa
oleifera
leaves
(MOL)
optimizing
the
different
experimental
factors
required
formation
stability
AgNPs.
was
confirmed
by
color
change
from
yellow
to
reddish-brown
with
surface
plasmon
resonance
band
at
412
nm.
morphology,
size,
elemental
composition
AgNPs
were
investigated
zeta
potential
dynamic
light
scattering,
field
emission
scanning
electron
microscopy,
energy
dispersive
X-ray,
X-ray
diffraction,
transmission
microscopy
analysis,
which
showed
crystalline
spherical
identification
functional
groups
supported
Fourier-transform
infrared
spectroscopy.
photocatalytic
activities
assessed
in
degradation
organic
Malachite
green
(MG)
dye
aqueous
solution.
Two
kinetic
adsorption
models,
pseudo-first-order
model
pseudo-second-order
model,
three
isotherm
Langmuir,
Freundlich,
Temkin,
used
mathematically
characterize
MG
process.
kinetics
Freundlich
found
be
good
agreement
data.
As
result
their
synergistic
interaction
MOL
solution,
activity
increases
they
can
successfully
adapt
photodegradation
dyes
industrial
effluents.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
273, С. 133089 - 133089
Опубликована: Июнь 14, 2024
This
review
shows
the
endeavors
performed
to
prepare
immobilized
formulations
of
bromelain
extract,
usually
from
pineapple,
and
their
use
in
diverse
applications.
extract
has
a
potent
proteolytic
component
that
is
based
on
thiol
proteases,
which
differ
depending
location
fruit.
Stem
fruit
are
areas
where
higher
activity
found.
The
edible
origin
this
enzyme
one
features
determines
applications
more
significant
degree.
been
wide
diversity
supports
via
different
strategies
(covalent
bonds,
ion
exchange),
also
forming
ex
novo
solids
(nanoflowers,
CLEAs,
trapping
alginate
beads,
etc.).
preexisting
nanoparticles
as
immobilization
relevant,
facilitates
main
enzyme,
therapeutic
(as
wound
dressing
healing
components,
antibacterial
or
anticancer,
mucus
mobility
control,
A
curiosity
spores
probiotic
microorganisms
adsorption,
order
have
perfect
vivo
compatibility.
Other
outstanding
stabilization
wine
versus
haze
during
storage,
mainly
when
chitosan.
Curiously,
scarcely
applied
production
bioactive
peptides.
Abstract
Rising
antibiotic
resistance
among
periodontal
pathogens
poses
a
major
challenge
to
treatment
outcomes.
This
work
investigates
the
possible
combinatorial
potential
of
AgNPs
synthesized
using
glycyrrhizin,
natural
biosurfactant,
combat
biofilm‐forming
bacteria
isolated
from
periodontitis
patients.
In
silico
findings
revealed
that
glycyrrhizin
had
higher
binding
affinity
score
‐9.102
compared
doxycycline
(−3.599)
for
gtfB
,
plays
an
indispensable
function
in
biofilm
integrity.
were
and
optimized
utilizing
design
experiments,
considering
factors
such
as
pH,
temperature,
incubation
time
concentration
variables.
while
The
resulting
GL‐AgNPs
characterized
by
different
analytical
techniques
FTIR,
XRD,
DLS,
SEM.
nanoparticles
non‐spherical,
uniform
average
size
72
nm,
zeta
potentials
ranged
−28
mV
−
42
mV.
Antimicrobial
suggested
exhibited
significant
antibacterial
anti‐biofilm
activity
prepared
sodium
borohydride
(
p
<
0.001).
Experimental
inhibited
formation
attenuating
Gtfase
activity.
Further,
show
effective
anti‐inflammatory
with
minimal
cytotoxicity.
Overall,
this
study
highlights
inherent
antimicrobial
surfactant
properties
greatly
improve
AgNPs,
providing
promising
approach
combating
biofilm‐producing
oral
periodontitis.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(4)
Опубликована: Фев. 26, 2025
ABSTRACT
The
recent
study
evaluated
the
protective
effect
of
Tribulus
platypterus
green‐synthesized
silver
nanoparticles
against
gentamicin‐induced
nephrotoxicity.
were
characterized
using
XRD,
UV‐Vis,
FT‐IR,
and
FE‐SEM.
exhibited
a
spherical
morphology
with
an
average
diameter
48
nm.
Both
traditional
innovative
kidney
injury
indicators
employed
to
evaluate
nephroprotective
effects
in
rat
model.
Administration
gentamicin
resulted
significant
reduction
(
p
≤
0.01)
Hb
concentration,
PCV,
RBC
count.
Conversely,
levels
creatinine,
erythropoietin,
serum
iron,
urea
increased
significantly
gentamicin‐treated
group.
leucogram
indicated
presence
leukocytosis,
granulocytosis,
thrombocytopenia.
Silver
enhanced
parameters
related
leukogram,
thrombocytes,
erythrogram.
In
animals
administered
AgNPs,
there
was
decrease
concentrations
urea,
AST,
ALT,
GGT,
ALP,
whereas
total
protein
albumin
showed
increase.
Furthermore,
AgNPs
notably
IL5,
IL10,
TGFβ,
IL3,
IL4,
while
simultaneously
reducing
TNFα,
IL6,
IL12,
IL18,
IL1.
These
results
suggest
that
could
serve
as
valuable
agent
derived
from
biological
source,
potentially
making
them
suitable
therapeutic
supplement
for
conditions
blood
disorders.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 21, 2025
Abstract
White
mustard
(
Sinapis
alba
L.)
seeds
are
the
most
commonly
used
species
in
herbal
medicine
to
treat
a
wide
range
of
inflammatory
disorders.
Due
its
increased
bioavailability
and
lower
toxicity,
green
biosynthesis
metal
nanoparticles
(M-NPs)
utilizing
plant
extract
as
capping
agent
has
been
demonstrated
over
number
years.
Thus,
current
study
sought
examine
vitro
biological
activity
copper
oxide
(CuO-NPs)
selenium
(Se-NPs)
that
were
biosynthesized
using
aqueous,
methanolic,
petroleum
ether
extracts
from
S.
seeds.
Phytochemical
activities
(antioxidant,
scavenging,
anti-diabetic,
anti-acetylcholinesterase,
anti-arthritic,
anti-inflammatory,
cytotoxic
activities)
assayed
all
prepared
before
after
being
for
M-NPs.
It
was
found
total
methanolic
possessed
highest
compared
other
native
extracts.
The
LC-ESI-MS/MS
analysis
secondary
metabolites
showed
contained
7
phenolic
acids
9
flavonoid
aglycones.
This
helped
find
active
ingredients.
We
characterized
8
acid
derivatives,
glycosides,
4
aliphatic
glucosinolates,
3
aromatic
aryl
glucosinolates
aqueous
extract.
Furthermore,
contains
concentrations
polyphenols,
condensed
tannins,
compounds.
Se-NPs
higher
those
CuO-NPs.
median
lethal
dose
(LD
50
)
studied
appeared
safer
findings
this
concluded
is
suitable
bioresource
biosynthesizing
through
nanotechnology,
with
efficiency
relation
metabolite
fingerprint.
