Cells,
Год журнала:
2022,
Номер
11(7), С. 1212 - 1212
Опубликована: Апрель 4, 2022
The
current
efforts
in
photodynamic
therapy
(PDT)
of
brain
cancer
are
focused
on
the
development
novel
photosensitizers
with
improved
properties,
targeted
specific
localization,
and
sensitivity
to
irradiation
dose,
ensuring
effectiveness
PDT
fewer
side
effects
for
normal
nerve
tissue.
Here,
we
characterize
four
tetracyanotetra(aryl)porphyrazine
group
(pz
I-IV)
functional
activity
neuron-glial
networks
primary
hippocampal
cultures
their
application
conditions
under
PDT.
data
revealed
that
pz
I-IV
leads
a
significant
decrease
main
parameters
calcium
pronounced
changes
network
characteristics.
observed
negative
were
aggravated
Considering
restructuring
architectonics
can
lead
severe
impairments
synaptic
transmission
loss
functions,
feasibility
direct
based
tumors
is
highly
controversial.
Nevertheless,
unique
properties
retain
great
prospect
use
another
origin
cellular
metabolism.
Physiological Reviews,
Год журнала:
2022,
Номер
102(4), С. 1625 - 1667
Опубликована: Апрель 4, 2022
For
nearly
50
years
the
proximal
tubule
(PT)
has
been
known
to
reabsorb,
process,
and
either
catabolize
or
transcytose
albumin
from
glomerular
filtrate.
Innovative
techniques
approaches
have
provided
insights
into
these
processes.
Several
genetic
diseases,
nonselective
PT
cell
defects,
chronic
kidney
disease
(CKD),
acute
injury
lead
significant
albuminuria,
reaching
nephrotic
range.
Albumin
is
also
stimulate
cascades.
Thus,
mechanisms
of
reabsorption,
catabolism,
transcytosis
are
being
reexamined
with
use
that
allow
for
novel
molecular
cellular
discoveries.
Megalin,
a
scavenger
receptor,
cubilin,
amnionless,
Dab2
form
multireceptor
complex
mediates
binding
uptake
directs
proteins
lysosomal
degradation
after
endocytosis.
mediated
by
pH-dependent
affinity
neonatal
Fc
receptor
(FcRn)
in
endosomal
compartments.
This
reclamation
pathway
rescues
urinary
losses
extending
its
serum
half-life.
altered
oxidation,
glycation,
carbamylation
because
other
bound
ligands
do
not
bind
FcRn
traffics
lysosome.
sorting
mechanism
reclaims
physiological
eliminates
potentially
toxic
albumin.
The
clinical
importance
metabolism
increased
as
now
used
therapeutic
agents
extend
their
half-life
minimize
filtration
injury.
purpose
this
review
update
integrate
evolving
information
regarding
reabsorption
processing
cells
including
discussion
disorders
considerations.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 477 - 477
Опубликована: Дек. 28, 2022
Mucopolysaccharidoses
(MPSs)
constitute
a
heterogeneous
group
of
lysosomal
storage
disorders
characterized
by
the
accumulation
glycosaminoglycans
(GAGs).
Although
dysfunction
is
mainly
affected,
several
cellular
organelles
such
as
mitochondria,
endoplasmic
reticulum,
Golgi
apparatus,
and
their
related
process
are
also
impaired,
leading
to
activation
pathophysiological
cascades.
While
supplying
missing
enzymes
mainstream
for
treatment
MPS,
including
enzyme
replacement
therapy
(ERT),
hematopoietic
stem
cell
transplantation
(HSCT),
or
gene
(GT),
use
modulators
available
restore
affected
recovering
homeostasis
may
be
simultaneous
approach.
This
review
summarizes
current
knowledge
about
consequences
GAGs
discusses
potential
that
can
reestablish
normal
function
beyond
ERT-,
HSCT-,
GT-based
alternatives.
Proceedings of the National Academy of Sciences,
Год журнала:
2023,
Номер
120(43)
Опубликована: Окт. 17, 2023
Liquid
droplet
has
emerged
as
a
flexible
intracellular
compartment
that
modulates
various
cellular
processes.
Here,
we
uncover
an
antimetastatic
mechanism
governed
by
the
liquid
droplets
formed
through
liquid–liquid
phase
separation
(LLPS)
of
SQSTM1/p62
and
neighbor
BRCA1
gene
1
(NBR1).
Some
tyrosine
kinase
inhibitors
(TKIs)
initiated
lysosomal
stress
response
promotes
LLPS
p62
NBR1,
resulting
in
spreading
p62/NBR1
droplets.
Interestingly,
droplet,
degradation
RAS-related
C3
botulinum
toxin
substrate
was
accelerated
inhibitor
apoptosis
protein
1,
which
limits
cancer
cell
motility.
Moreover,
activity
TKIs
completely
overridden
double
knockout
cells
both
vitro
vivo.
Thus,
our
results
demonstrate
function
critical
determinant
behavior,
may
provide
insight
into
clinical
biological
significance
LLPS.
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
677, С. 842 - 852
Опубликована: Авг. 16, 2024
Nanoparticles
have
become
versatile
assets
in
the
medical
field,
providing
notable
benefits
across
diverse
arenas
including
controlled
drug
delivery,
imaging,
and
immunological
assays.
Among
these,
non-lamellar
lipid
nanoparticles,
notably
cubosomes
hexosomes,
showcase
remarkable
biocompatibility
stability,
rendering
them
as
optimal
choices
for
theranostic
applications.
Particularly,
incorporating
edge
activators
like
sodium
taurocholate
enhances
potential
of
these
nanoparticles
dermal
transdermal
overcoming
stratum
corneum,
a
first
line
defense
our
skin.
This
study
reports
on
formulation
monoolein-based
hexosomes
stabilized
by
Span
80
co-encapsulating
Chlorin
e6
coenzyme
QH
photodynamic
therapy
skin
metastatic
melanoma.
The
formulations
were
optimized
using
small-angle
X-ray
scattering,
cryo-transmission
electron
microscopy
confirmed
presence
or
depending
ratio
between
80.
Furthermore,
co-loaded
exhibited
high
encapsulation
efficiencies
both
Ce6
QH.
In
vitro
studies
human
melanoma
cells
(Me45)
demonstrated
activity
loaded
formulations.
These
findings
show
possibility
formulating
more
biocompatible
cancer
treatment.
Cells,
Год журнала:
2022,
Номер
11(19), С. 3093 - 3093
Опубликована: Окт. 1, 2022
In
this
review,
we
shed
light
on
recent
advances
regarding
the
characterization
of
biochemical
pathways
cellular
mechanosensing
and
mechanotransduction
with
particular
attention
to
their
role
in
neurodegenerative
disease
pathogenesis.
While
mechanistic
components
these
are
mostly
uncovered
today,
crosstalk
between
mechanical
forces
soluble
intracellular
signaling
is
still
not
fully
elucidated.
Here,
recapitulate
general
concepts
mechanobiology
mechanisms
that
govern
processes,
examine
stimuli
response,
highlighting
effect
organelles'
homeostasis
dysfunction.
particular,
discuss
current
knowledge
about
translation
mechanosignaling
into
signaling,
focusing
those
diseases
encompass
metabolic
accumulation
mutant
proteins
have
as
primary
characteristics
formation
pathological
aggregates,
such
Alzheimer's
Disease,
Huntington's
Amyotrophic
Lateral
Sclerosis
Parkinson's
Disease.
Overall,
findings
elucidate
how
may
be
crucial
understand
pathogenic
underlying
emphasize
importance
for
identifying
potential
therapeutic
targets.
