The Cancer Journal,
Год журнала:
2023,
Номер
29(6), С. 287 - 292
Опубликована: Ноя. 1, 2023
The
United
States
has
seen
a
33%
decline
in
age-adjusted
cancer
mortality
since
1991.
Despite
this
achievement,
the
some
of
greatest
health
disparities
any
developed
nation.
US
government
policies
are
increasingly
directed
toward
reducing
and
promoting
equity.
These
govern
conduct
research,
prevention,
access,
payment
for
care.
Although
implementation
played
significant
role
successes
control,
inconsistent
policy
resulted
divergent
outcomes;
poorly
designed
or
inadequately
implemented
have
hindered
progress
death
rates
and,
certain
cases,
exacerbated
existing
disparities.
Examining
affecting
control
realizing
their
unintended
consequences
crucial
addressing
inequities.
Psychosomatic Medicine,
Год журнала:
2023,
Номер
86(5), С. 443 - 452
Опубликована: Ноя. 16, 2023
ABSTRACT
Objective
Lower
socioeconomic
status
(SES)
can
accelerate
immune
aging;
however,
it
is
unknown
whether
and
how
lifespan
context
(SEC)—the
relative
wealth
quality
of
the
communities
an
individual
lives
in
across
their
lifespan—impacts
aging.
We
examined
effects
childhood
adulthood
SEC
on
late-differentiated
cells
investigated
mediating
moderating
role
cytomegalovirus
(CMV),
a
key
driver
Methods
Adults
60
years
older
(
N
=
109)
reported
addresses
from
birth
to
age
years,
which
were
coded
for
county-level
employment,
education,
income
construct
latent
variable,
averaged
ages
0
18
(childhood
SEC)
19
(adulthood
SEC).
Blood
was
drawn
semiannually
5
CMV
serostatus
flow
cytometry
estimates
CD8
+
T
natural
killer
cells.
Models
adjusted
chronological
age,
time,
sex,
SES
(current
education).
Results
associated
with
higher
percentages
via
seropositivity
(indirect
effects,
p
values
.015–.028).
In
addition,
interaction
between
T-cell
aging
.049)
demonstrated
that
negatively
among
CMV−
but
not
CMV+
adults.
Conclusions
Beyond
current
SES,
related
distinct
patterns
by
phase.
importantly
may
influence
who
acquires
CMV,
turn
predicts
levels
aging,
whereas
protective
against
These
initial
results
need
be
explored
larger
samples.
The Cancer Journal,
Год журнала:
2023,
Номер
29(6), С. 287 - 292
Опубликована: Ноя. 1, 2023
The
United
States
has
seen
a
33%
decline
in
age-adjusted
cancer
mortality
since
1991.
Despite
this
achievement,
the
some
of
greatest
health
disparities
any
developed
nation.
US
government
policies
are
increasingly
directed
toward
reducing
and
promoting
equity.
These
govern
conduct
research,
prevention,
access,
payment
for
care.
Although
implementation
played
significant
role
successes
control,
inconsistent
policy
resulted
divergent
outcomes;
poorly
designed
or
inadequately
implemented
have
hindered
progress
death
rates
and,
certain
cases,
exacerbated
existing
disparities.
Examining
affecting
control
realizing
their
unintended
consequences
crucial
addressing
inequities.
