SIRT1 Activation by Natural Phytochemicals: An Overview

Frontiers in Pharmacology, Год журнала: 2020, Номер 11

Опубликована: Авг. 7, 2020

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+ as a cofactor. reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead tissue-specific degenerative events involved in the development several human pathologies, including cancer, neurodegeneration, cardiovascular disease. The most studied member this enzymes sirtuin 1 (SIRT1), associated with increasing insulin sensitivity. SIRT1 has been implicated both tumorigenic anticancer processes, regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders metabolism. Via regulation p53 deacetylation modulation autophagy, cellular response caloric restriction lifespan extension. In recent years, scientific interest focusing identification modulators led discovery novel small molecules targeting activity. This review will examine compounds natural origin recently found upregulate activity, such polyphenolic products fruits, vegetables, plants resveratrol, fisetin, quercetin, curcumin. We also discuss potential therapeutic effects these prevention treatment disorders, particular emphasis impact.

Язык: Английский

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Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113887 - 113887

Опубликована: Июль 24, 2021

Язык: Английский

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Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer

Phytomedicine, Год журнала: 2023, Номер 114, С. 154792 - 154792

Опубликована: Март 30, 2023

Язык: Английский

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Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis

Phytomedicine, Год журнала: 2024, Номер 128, С. 155258 - 155258

Опубликована: Янв. 11, 2024

Язык: Английский

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Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms

Nutrients, Год журнала: 2023, Номер 15(16), С. 3578 - 3578

Опубликована: Авг. 14, 2023

Sirtuins are a family of proteins with enzymatic activity. There seven mammalian sirtuins (SIRT1-SIRT7) that found in different cellular compartments. They part crucial pathways and regulated by many factors, such as chemicals, environmental stress, phytochemicals. Several vitro vivo studies have presented their involvement anti-inflammatory, antioxidant, antiapoptotic processes. Recent findings imply phytochemicals resveratrol, curcumin, quercetin, fisetin, berberine, kaempferol may regulate the activity sirtuins. Resveratrol mainly activates SIRT1 indirectly AMPK. Curcumin influences SIRT3, but its is broad, cells affected. Quercetin modulates SIRT1, which triggers antioxidant responses. Fisetin, through regulation, modifies lipid metabolism anti-inflammatory Berberine has wide spectrum effects significant impact on signaling pathways. Finally, induction. This review aims to summarize recent properties modulation sirtuin activity, particular focus biochemical aspects.

Язык: Английский

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Tailoring traditional Chinese medicine in cancer therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 21, 2025

Язык: Английский

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Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1098 - 1098

Опубликована: Янв. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Язык: Английский

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Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro

Viruses, Год журнала: 2021, Номер 13(2), С. 282 - 282

Опубликована: Фев. 11, 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a new human pathogen in late 2019 and it has infected over 100 million people less than year. There is clear need for effective antiviral drugs to complement current preventive measures, including vaccines. In this study, we demonstrate that berberine obatoclax, two broad-spectrum compounds, are against multiple isolates of SARS-CoV-2. Berberine, plant-derived alkaloid, inhibited SARS-CoV-2 at low micromolar concentrations which was originally developed an anti-apoptotic protein antagonist, sub-micromolar concentrations. Time-of-addition studies indicated acts on the stage viral life cycle. agreement, mildly affected RNA synthesis, but strongly reduced infectious titers, leading increase particle-to-pfu ratio. contrast, obatoclax acted early infection, line with its activity neutralize acidic environment endosomes. We assessed infection primary nasal epithelial cells were cultured air-liquid interface found induced repressed expression specific sets cytokines chemokines. Moreover, both replication these target cells. propose potential could be considered further efficacy testing.

Язык: Английский

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Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends

Molecules, Год журнала: 2022, Номер 27(12), С. 3705 - 3705

Опубликована: Июнь 9, 2022

Traditionally, herbal compounds have been the focus of scientific interest for last several centuries, and continuous research into their medicinal potential is underway. Berberine (BBR) an isoquinoline alkaloid extracted from plants that possess a broad array properties, including anti-diarrheal, anti-fibrotic, antidiabetic, anti-inflammatory, anti-obesity, antihyperlipidemic, antihypertensive, antiarrhythmic, antidepressant, anxiolytic effects, frequently utilized as traditional Chinese medicine. BBR promotes metabolisms glucose lipids by activating adenosine monophosphate-activated protein kinase, stimulating glycolysis inhibiting functions mitochondria; all these ameliorate type 2 diabetes mellitus. has also shown to benefits in congestive heart failure, hypercholesterolemia, atherosclerosis, non-alcoholic fatty liver disease, Alzheimer’s polycystic ovary syndrome. investigated interesting pharmacophore with contribute significantly development novel therapeutic medicines variety disorders. Despite its enormous promise, clinical application this was severely limited because unpleasant pharmacokinetic characteristics. Poor bioavailability, absorption, poor water solubility are some obstacles restricted use. Nanotechnology suggested possible solution problems. The present review aims at recent updates on important activities different types nanocarriers used delivery diseases.

Язык: Английский

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Photonic and magnetic materials for on-demand local drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 191, С. 114584 - 114584

Опубликована: Окт. 21, 2022

Nanomedicine has been considered a promising tool for biomedical research and clinical practice in the 21st century because of great impact nanomaterials could have on human health. The generation new smart nanomaterials, which enable time- space-controlled drug delivery, improve limitations conventional treatments, such as non-specific targeting, poor biodistribution permeability. These can respond to internal biological stimuli (pH, enzyme expression redox potential) and/or external (such temperature, ultrasound, magnetic field light) further precision therapies. To this end, photonic nanoparticles, gold, silver iron oxide, used increase sensitivity responsiveness stimuli. In review, we aim report main most recent systems that involve or stimulus-responsive release. uniqueness review lies highlighting versatility integrating these materials within different carriers. This leads enhanced performance terms vitro vivo efficacy, stability toxicity. We also point out current regulatory challenges translation from bench bedside, well yet unresolved matter regarding standardization materials.

Язык: Английский

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