Pharmaceutics,
Год журнала:
2022,
Номер
14(4), С. 822 - 822
Опубликована: Апрель 8, 2022
Inflammatory
bowel
disease
(IBD)
is
a
chronic
recurrent
intestinal
and
includes
Crohn's
(CD)
ulcerative
colitis
(UC).
Due
to
the
complex
etiology
of
colitis,
current
treatments
IBD
are
quite
limited
mainly
concentrated
on
remission
disease.
In
addition,
side
effects
conventional
drugs
body
cannot
be
ignored.
also
has
certain
relationship
with
colitis-associated
cancer
(CAC),
inflammatory
cells
can
produce
large
number
tumor-promoting
cytokines
promote
tumor
progression.
recent
years,
exosomes
from
plants
have
been
found
ability
load
target
intestine
great
potential
for
treatment
diseases.
This
plant-derived
exosome-targeting
delivery
system
chemical
or
nucleic
acid
deliver
them
sites
stably
efficiently.
review
summarizes
pathophysiological
characteristics
CAC
as
well
application
prospect
plant
in
CAC.
Bacterial
infection
has
become
one
of
the
leading
causes
death
worldwide,
particularly
in
low-income
countries.
Despite
fact
that
antibiotics
have
provided
successful
management
bacterial
infections,
long-term
overconsumption
and
abuse
contributed
to
emergence
multidrug
resistant
bacteria.
To
address
this
challenge,
nanomaterials
with
intrinsic
antibacterial
properties
or
serve
as
drug
carriers
been
substantially
developed
an
alternative
fight
against
infection.
Systematically
deeply
understanding
mechanisms
is
extremely
important
for
designing
new
therapeutics.
Recently,
nanomaterials-mediated
targeted
bacteria
depletion
either
a
passive
active
manner
most
promising
approaches
treatment
by
increasing
local
concentration
around
cells
enhance
inhibitory
activity
reduce
side
effects.
Passive
targeting
approach
widely
explored
searching
nanomaterial-based
alternatives
antibiotics,
while
strategy
relies
on
biomimetic
biomolecular
surface
feature
can
selectively
recognize
In
review
article,
we
summarize
recent
developments
field
therapy
based
nanomaterials,
which
will
promote
more
innovative
thinking
focusing
multidrug-resistant
A
therapeutic
strategy
that
targets
multiple
proinflammatory
factors
in
inflammatory
bowel
disease
(IBD)
with
minimal
systemic
side
effects
would
be
attractive.
Here,
we
develop
a
drug-free,
biodegradable
nanomedicine
acts
against
IBD
by
scavenging
cell-free
DNA
(cfDNA)
and
reactive
oxygen
species
(ROS).
Polyethylenimine
(PEI)
was
conjugated
to
antioxidative
diselenide-bridged
mesoporous
organosilica
nanoparticles
(MONs)
formulate
(MON-PEI)
exhibited
high
cfDNA
binding
affinity
ROS-responsive
degradation.
In
ulcerative
colitis
Crohn’s
mouse
models,
orally
administered
MON-PEI
accumulated
preferentially
the
inflamed
colon
attenuated
colonic
peritoneal
inflammation
alleviating
cfDNA-
ROS-mediated
responses,
allowing
reduced
dose
frequency
ameliorating
even
after
delayed
treatment.
This
work
suggests
new
for
Phytotherapy Research,
Год журнала:
2022,
Номер
36(5), С. 2081 - 2094
Опубликована: Март 1, 2022
This
study
aimed
to
analyze
the
therapeutic
effect
of
Rhein
on
ulcerative
colitis
(UC)
in
mice
and
its
possible
mechanism.
LPS-induced
UC
cell
model
DSS-induced
mouse
were
used
antiinflammatory
vitro
vivo,
respectively.
Network
pharmacology
analysis
was
conducted
identify
potential
signaling
pathways
involved
treating
UC,
results
further
confirmed
through
western
blotting
assay.
16sRNA
sequencing
performed
regulatory
gut
microbiota
mice.
As
indicated
by
results,
could
significantly
inhibit
production
pro-inflammatory
cytokines
(e.g.,
TNF-α,
IL-6
IL-1β)
vivo
vitro,
alleviate
UC-associated
symptoms
colon
shortening,
weight
loss,
diarrhea
hematochezia).
The
PI3K/Akt/mTOR
pathway
predicted
as
interacting
protein
treatment
network
analysis.
It
found
assay
that
decreasing
phosphorylated
levels
PI3K,
Akt,
mTOR
p70S6K1.
By
gene
analysis,
administration
partially
reverse
dysbacteriosis
induced
DSS
decrease
pathogenic
bacteria
Enterobacteriaceae
Turicibacter).
positively
correlated
with
above,
whereas
increase
probiotics
Unspecified-S24-7
Rikenellaceae)
negatively
cytokines.
In
conclusion,
Rhine
had
anti-UC
efficacy,
which
demonstrated
mitigating
reducing
intestinal
inflammation
inhibiting
modulating
microbiota.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Авг. 31, 2022
Abstract
The
rapid
advancement
of
nanomedicine
and
nanoparticle
(NP)
materials
presents
novel
solutions
potentially
capable
revolutionizing
health
care
by
improving
efficacy,
bioavailability,
drug
targeting,
safety.
NPs
are
intriguing
when
considering
medical
applications
because
their
essential
unique
qualities,
including
a
significantly
higher
surface
to
mass
ratio,
quantum
properties,
the
potential
adsorb
transport
drugs
other
compounds.
However,
must
overcome
or
navigate
several
biological
barriers
human
body
successfully
deliver
at
precise
locations.
Engineering
carrier
biointerface
can
help
main
optimize
delivery
in
more
personalized
manner.
This
review
discusses
significant
heterogeneous
how
engineering
promote
carriers
prevail
over
hurdles
manner,
thus
ushering
era
Precision
Medicine.
We
also
summarize
nanomedicines'
current
advantages
disadvantages
administration,
from
natural/synthetic
sources
clinical
applications.
Additionally,
we
explore
innovative
NP
designs
used
both
non-personalized
customized
as
well
they
attain
therapeutic
strategy.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Янв. 4, 2023
While
several
artificial
nanodrugs
have
been
approved
for
clinical
treatment
of
breast
tumor,
their
long-term
applications
are
restricted
by
unsatisfactory
therapeutic
outcomes,
side
reactions
and
high
costs.
Conversely,
edible
plant-derived
natural
nanotherapeutics
(NTs)
source-widespread
cost-effective,
which
shown
remarkably
effective
in
disease
treatment.
Herein,
we
extracted
purified
exosome-like
NTs
from
tea
leaves
(TLNTs),
had
an
average
diameter
166.9
nm
a
negative-charged
surface
-
28.8
mV.
These
TLNTs
contained
adequate
slew
functional
components
such
as
lipids,
proteins
pharmacologically
active
molecules.
In
vitro
studies
indicated
that
were
effectively
internalized
tumor
cells
(4T1
cells)
caused
2.5-fold
increase
the
amount
intracellular
reactive
oxygen
species
(ROS)
after
incubation
8
h.
The
levels
ROS
triggered
mitochondrial
damages
arrested
cell
cycles,
resulting
apoptosis
cells.
mouse
experiments
revealed
achieved
good
effects
against
tumors
regardless
intravenous
injection
oral
administration
through
direct
pro-apoptosis
microbiota
modulation.
Strikingly,
TLNTs,
not
administration,
yielded
obvious
hepatorenal
toxicity
immune
activation.
findings
collectively
demonstrate
can
be
developed
promising
platform
cancer.
Resveratrol
is
a
polyphenol
with
diverse
pharmacological
activities,
but
its
clinical
efficacy
limited
due
to
low
solubility/permeability,
light-induced
isomerization,
auto-oxidation,
and
rapid
metabolism.
Nanodelivery
systems,
such
as
liposomes,
polymeric
nanoparticles,
lipid
nanocarriers,
micelles,
nanocrystals,
inorganic
nanoemulsions,
protein-based
exosomes,
macrophages,
red
blood
cells
(RBCs)
have
shown
great
potential
for
improving
the
solubility,
biocompatibility,
therapeutic
of
resveratrol.
This
review
comprehensively
summarizes
recent
advances
in
resveratrol
nanoencapsulation
describes
strategies
improve
pharmacokinetics
existing
nanoformulations,
enhance
targeting,
reduce
toxicity,
increase
drug
release
encapsulation
efficiency.
The
article
also
suggests
that
order
avoid
safety
issues,
nanoformulations
must
be
tested
vivo
wide
range
diseases.
