Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Янв. 27, 2022

Cancer is the leading cause of death and one greatest barriers to increased life expectancy worldwide. Currently, chemotherapy with synthetic drugs remains predominant ways for cancer treatment, which may lead drug resistance normal organ damage. Increasing researches have suggested that apoptosis, a type programmed cell death, promising way therapy. Furthermore, natural products are important sources finding new high availability, low cost toxicity. As well-known isoquinoline alkaloid, accumulating evidence has revealed berberine (BBR) exerts potential pro-apoptotic effects on multiple cancers, including breast, lung, liver, gastric, colorectal, pancreatic, ovarian cancers. The related signal pathways AMP-activated protein kinase, mitogen-activated kinase B pathways. In this review, we provide timely comprehensive summary detailed molecular mechanisms BBR in treating three types (breast, lung liver cancer) by inducing apoptosis. also discuss existing challenges strategies improve BBR's bioavailability. Hopefully, review provides valuable information comprehension highlight BBR, would be beneficial further development compound as an effective clinical

Язык: Английский

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Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Дек. 6, 2022

Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long history of treating dysentery in the clinic. Over past two decades, polytrophic, pharmacological, and biochemical properties BBR have been intensively studied. The key functions BBR, including anti-inflammation, antibacterial, antioxidant, anti-obesity, even antitumor, discovered. However, underlying mechanisms BBR-mediated regulation still need to be explored. Given that is also natural nutrition supplement, modulatory effects on nutritional immune responses attracted more attention investigators. In this mini-review, we summarized latest achievements inflammation, gut microbes, macrophage polarization, associated with their possible tools pathogenesis therapy ulcerative colitis cancer recent 5 years. We discuss therapeutic efficacy anti-inflammatory actions benefit future clinical applications.

Язык: Английский

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Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications

Antioxidants, Год журнала: 2023, Номер 12(10), С. 1883 - 1883

Опубликована: Окт. 19, 2023

Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis chinensis and other Berberis plants. BBR possesses various bioactivities, including antioxidant, anti-inflammation, anticancer, immune-regulation, antimicrobial activities. Growing scientific evidence underscores BBR’s substantial neuroprotective potential, prompting increased interest scrutiny. In this comprehensive review, we elucidate the attributes of BBR, delineate underlying molecular mechanisms, assess its clinical safety efficacy. The multifaceted mechanisms responsible for neuroprotection encompass attenuation oxidative stress, mitigation inflammatory responses, inhibition apoptotic pathways, facilitation autophagic processes, modulation CYP450 enzyme activities, neurotransmitter levels, gut microbiota composition. Furthermore, engages numerous signaling PI3K/Akt, NF-κB, AMPK, CREB, Nrf2, MAPK to confer effects. This review aims provide a knowledge base, stimulate broader discourse, facilitate advancements in application neuroprotection.

Язык: Английский

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Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115210 - 115210

Опубликована: Июль 25, 2023

This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (QLYD) against atherosclerosis (AS) through network pharmacology, molecular docking, bioinformatic analysis experimental validation.The compositions QLYD were collected from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP) literature, where main active components corresponding identified. The therapeutic AS excavated using OMIM database, DrugBank DisGeNET CTD database GEO datasets. protein-protein interaction (PPI) common was constructed visualized by Cytoscape 3.7.2 software. Gene ontology (GO) Kyoto encyclopedia genes genomes (KEGG) performed to analyze function core in PPI network. Molecular docking carried out AutoDockTools, AutoDock Vina, PyMOL software verify correlation between targets. Mouse model established results pharmacology verified vivo experiments.Totally 49 225 obtained, 68 identified intersecting with AS-related Five hub including IL6, VEGFA, AKT1, TNF, IL1B screened GO reported that these had associations mainly cellular response oxidative stress, regulation inflammatory response, epithelial cell apoptotic process, blood coagulation. KEGG pathway demonstrated correlated AGE-RAGE signaling diabetic complications, TNF pathway, IL-17 MAPK NF-kappa B pathway. Results indicated good binding affinity FOS, TNF. Animal experiments showed could inhibit inflammation, improve lipid levels reduce plaque area mice prevent treat AS.QLYD may exert anti-inflammatory anti-oxidative stress effects multi-component, multi-target multi-pathway AS.

Язык: Английский

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Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Gels, Год журнала: 2023, Номер 9(5), С. 431 - 431

Опубликована: Май 22, 2023

Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons Bombyx mori through alkali or enzymatic treatments. SF exhibits biological properties, such as mechanical biocompatibility, biodegradability, bioabsorbability, low immunogenicity, tunability, making it a versatile material widely applied in fields, particularly tissue engineering. In engineering, often fabricated into hydrogel form, with advantages added materials. hydrogels have mostly been studied for their use regeneration enhancing cell activity at defect site counteracting tissue-damage-related factors. This review focuses on hydrogels, firstly summarizing fabrication properties then detailing regenerative effects scaffolds cartilage, bone, skin, cornea, teeth, eardrum recent years.

Язык: Английский

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Natural self-healing injectable hydrogels loaded with exosomes and berberine for infected wound healing

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100875 - 100875

Опубликована: Ноя. 19, 2023

Complete and rapid healing of infected skin wounds remains a challenge in current clinical treatment. In this study, we prepared self-healing injectable CK hydrogel by crosslinking two natural polysaccharides, carboxymethyl chitosan oxidized konjac glucomannan, based on the Schiff base bond. To enhance biological function hydrogel, multi-functionalized hydrogen loading it with berberine (BBR) stem cell-derived exosomes (Exo), forming composite CK@BBR&Exo, which could be injected directly into wound through needle adhered to wound. Furthermore, properties CK@BBR&Exo increased its usefulness service life. Additionally, drug-loaded was versatile, inhibiting bacterial growth, regulating inflammatory response, promoting neovascularization wounds, thus achieving wounds. These results suggest that CK@BBR&Exo-injectable is an ideal dressing for treating

Язык: Английский

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Proceedings of the International Scientific and Practical Conference

Опубликована: Дек. 7, 2023

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Язык: Английский

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Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 159, С. 114226 - 114226

Опубликована: Янв. 17, 2023

Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, can lead to decreased lung function, respiratory failure even death. The pathogenesis research treatment strategy of PF significantly lag behind the medical progress clinical needs. this disease remains thorny problem, effective therapeutic drugs are still limited. Monomeric compounds from traditional Chinese medicine own various biological activities high safety. They play broad part in treating diseases also candidate drug for preventing PF. In paper, we reviewed mechanism action potential value anti-PF monomeric medicine. These attenuate inflammatory response, oxidative stress, epithelial mesenchymal transformation other processes through many signaling pathways, inhibit activation differentiation fibroblasts, thus contributing This review provide new ideas development efficiency with low toxicity.

Язык: Английский

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Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Язык: Английский

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Emerging Trends in Bilosomes as Therapeutic Drug Delivery Systems

Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 697 - 697

Опубликована: Май 23, 2024

In recent years, there has been a notable surge in the utilization of stabilized bile acid liposomes, chemical conjugates, complexes, mixed micelles, and other drug delivery systems derived from acids, often referred to as bilosomes. The molecular structure interactions these amphiphilic compounds provide distinctive captivating subject for investigation. enhanced stability new generation bilosomes inside gastrointestinal system results prevention degradation an improvement mucosal penetration. These characteristics render be prospective nanocarrier pharmaceutical administration, prompting researchers investigate their potential domains. This review paper discusses that have emerged viable modality realm significant promise use across several Moreover, this underscores need additional investigation advancement order comprehensively comprehend uses effectiveness field administration. study explores current scholarly attention on carriers delivery. Therapeutic areas where shown outstanding performance terms are outlined graphical abstract.

Язык: Английский

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