Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS/NF-κB pathway to regulate macrophage polarization

Carbohydrate Polymers, Год журнала: 2024, Номер 345, С. 122574 - 122574

Опубликована: Авг. 6, 2024

Язык: Английский

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Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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The prevention of multi-drug resistance in cancers through the application of nanotechnology-based targeted delivery systems for combination therapies involving traditional Chinese medicine

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100386 - 100386

Опубликована: Фев. 4, 2024

The most significant obstacle in addressing cancer is the development of multidrug resistance during chemotherapy. Cancer cells have ability to endure numerous cycles traditional chemotherapy drugs before ultimately developing treatment. Combining a strategy used address problem resistance. Persistent challenges with synthetic include catastrophic adverse reactions and other consequences. Natural compounds originating from Chinese medicine are acknowledged for their minimal toxicity possible benefits reversing induced by mainstream chemotherapeutic or targeted treatments. (MDR) an immediate clinical justification unsatisfactory recurrence metastasis precipitated MDR, leading high risk death. unique nano-delivery method therapeutic management MDR cancers has emerged as key use nanotechnology. Because its anticancer prospective, (TCM)-combination therapy emerging treatment modality essential option cancer. By precisely regulating release medicines delivering pharmaceuticals cancerous cells, nano drug-delivery devices offer amazing pave way growth TCM-combination therapies. present review examines literature on three important topics: mechanism chemotherapy, role herbs formulation treatment, incorporation TCM nanotechnology-based drug delivery systems circumvent limitations system. Major sources work PubMed, Google Scholar, ResearchGate, Embase, ScienceDirect. All aspects pertaining TCM, nanotechnology more than 50 years were considered, emphasis formulation, various forms advances system result nanotechnology, everything else between. As becomes closely associated realm practice broadening. Furthermore, it enhances prospects future research facilitates advancement modern Traditional Medicine (TCM). integrating into meticulously designed system, will enhance both treat prevent diseases even greater efficacy previously. This article nano-TCM explores characteristics, compositions, relevant techniques preparation application MDR. In addition, comprehensive elucidation had been given respect objective this study was analyze existing body (TCM) that can be encompasses like active components utilization (MDR), potential advancements obstacles TCM-based combinations.

Язык: Английский

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Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics

Advanced Functional Materials, Год журнала: 2024, Номер 34(32)

Опубликована: Май 6, 2024

Abstract Efforts to develop advanced bone substitutes for effective regeneration in substantial defects have led the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential mimicking native tissue. Inspired by biomineralization process, hydrothermal treatment is used synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling structure bone‐like apatite induced hydroxyapatite vivo. The vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. upregulation proteins BMP2 ITGB1, along downregulation osteoclastic FGF21 IGFBP1, synergistic effect biomimetic on activation MAPK signaling pathway. In vivo, showe early angiogenic capabilities, leading improved critical‐size femoral osteoporotic rats. Histological staining confirms complete bridging new tissue group, nanoindentation tests indicate formation mature mineralized Collectively, these findings suggest a novel strategy fabricating bone‐mimicking constructs potential applications disease modeling.

Язык: Английский

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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

Язык: Английский

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Detoxification and underlying mechanisms towards toxic alkaloids by Traditional Chinese Medicine processing: A comprehensive review

Phytomedicine, Год журнала: 2024, Номер 129, С. 155623 - 155623

Опубликована: Апрель 17, 2024

Alkaloids gained long-lasting interest worldwide for their extraordinary therapeutic effects of analgesic, anti-inflammation, and anti-tumor, offering a rich source lead compound design new drug discovery. However, some these alkaloids possess intrinsic toxicity. Processing (Paozhi) is pre-processing step before herbal medicines' application in traditional Chinese medicine (TCM) clinics, which has been employed centuries to mitigate the toxicity alkaloid-rich TCMs. To explore phenotypes, chemical basis, mode action, detoxification processing methods, underlying mechanisms, we can gain crucial insights into safe rational use toxic herbs, have great potential offer strategies discovery development, help improve quality life millions people. Literatures published or early accessed until December 31, 2023, were retrieved from databases including PubMed, Web Science, CNKI. The following keywords, such as "toxicity", "alkaloid", "detoxification", "processing", "traditional medicine", "medicinal plant", "plant", used combined separately screening. Toxicity TCM hepatotoxicity, nephrotoxicity, neurotoxicity, cardiotoxicity, other forms toxicity, primarily induced by pyrrolizidines, quinolizidines, isoquinolines, indoles, pyridines, terpenoids, amines. Whether toxic-alkaloid enriched part limited, heat-sensitive, are also components, critical factors choosing appropriate methods. mechanisms towards alkaloid-toxin includes physical removal, decomposition transformation, well biological modifications. Through this exploration, review possessing methods reduce unravel intricate behind detoxification, control herbs containing alkaloids, TCMs

Язык: Английский

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Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.

Язык: Английский

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Enhancing Efficacy and Mitigating Toxicity of Semen Strychni: From Traditional Practices to Modern Pharmaceutical Innovations

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119515 - 119515

Опубликована: Фев. 1, 2025

Язык: Английский

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Nano technology-based drug delivery systems and herbal medicine

Journal of Drug Delivery and Therapeutics, Год журнала: 2025, Номер 15(3), С. 133 - 141

Опубликована: Март 15, 2025

Nanotechnology has revolutionized the field of herbal medicine by enhancing bioavailability and efficacy phytoconstituents. This review article discusses application nanotechnology in medicine, including use nanoparticles, liposomes, nanoemulsions for targeted drug delivery. The advantages nanotechnology-based formulations, such as improved solubility, stability, bioavailability, are highlighted. Additionally, potential therapeutic medicines, their anti-inflammatory, antioxidant, anticancer properties. also explores various types nanocarriers used polymeric solid lipid nanostructured carriers. role permeability retention medicines body is discussed. Overall, provides a comprehensive overview highlighting its Keywords: Nanotechnology, Herbal Liposomes, Nanosuspension, Nano emulsion.

Язык: Английский

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Unassuming Lichens: Nature’s Hidden Antimicrobial Warriors

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3136 - 3136

Опубликована: Март 28, 2025

In a hidden corner of the Earth, an ongoing war is being waged: battle between lichens and microorganisms. Lichens, ancient unique symbiotic organisms, with their survival wisdom, are bursting vitality in extreme environments. Over 80% secondary metabolites not found other making lichen-derived compounds promising resource for development new drugs, particularly against drug-resistant microorganisms, due to distinctive chemical structures biological activities. This article aims explore depth lichen species exhibiting antimicrobial activity focus on such as divaricatic acid, usnic vulpinic salazinic rhizocarpic which demonstrate significant effects various resistant including methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Candida albicans Meanwhile, this paper discusses potential applications challenges associated use medicine, agriculture, food industry, aiming elucidate these mysterious organisms researchers enthusiasts while promoting further research field antimicrobials.

Язык: Английский

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