Опубликована: Янв. 1, 2024
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Язык: Английский
Gut, Год журнала: 2024, Номер 73(10), С. 1749 - 1762
Опубликована: Июнь 8, 2024
Mounting evidence underscores the pivotal role of intestinal barrier and its convoluted network with diet microbiome in pathogenesis inflammatory bowel disease (IBD) colitis-associated colorectal cancer (CRC). Moreover, bidirectional association liver brain, known as gut-brain axis, plays a crucial developing complications, including extraintestinal manifestations IBD CRC metastasis. Consequently, healing represents therapeutic target these inflammatory-dependent disorders, assessment predicting outcomes, response to therapy manifestations.New advanced technologies are revolutionising our understanding paradigm, enabling accurate aiding unravelling complexity axis. Cutting-edge endoscopic imaging techniques, such ultra-high magnification endocytoscopy probe-based confocal laser endomicroscopy, new allowing real-time exploration 'cellular' barrier. Additionally, novel spatial technology platforms, multispectral imaging, upconversion nanoparticles, digital profiling, optical spectroscopy mass cytometry, enable deep comprehensive 'molecular' 'ultrastructural' In this promising landscape, artificial intelligence standardising integrating tools, thereby contributing prediction outcomes.Looking ahead, integrated approach holds promise uncovering targets, breaking ceiling IBD. Novel molecules, dietary interventions modulation strategies aim restore, reinforce, or modulate These advancements have potential for transformative personalised approaches managing
Язык: Английский
Процитировано
19
Gut Microbes, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 24, 2025
The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in health of host development diseases. As vital component intestinal microecosystem, influences synthesis release many through mechanisms such as modulating environment, producing metabolites, impacting mucosal barriers, generating immune inflammatory responses, releasing neurotransmitters. Conversely, exert feedback regulation on by nutrient absorption utilization, bacterial biological behavior composition. distributions are anatomically intertwined, close interactions crucial for maintaining homeostasis. Interventions leveraging have been employed clinical management metabolic diseases bowel diseases, bariatric surgery fecal transplantation, offering promising targets treatment dysbiosis-related
Язык: Английский
Процитировано
2
European Journal of Internal Medicine, Год журнала: 2023, Номер 119, С. 13 - 30
Опубликована: Окт. 4, 2023
Язык: Английский
Процитировано
29
BMC Microbiology, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 3, 2024
Abstract Background Colorectal cancer (CRC) is a prevalent malignant malignancy affecting the gastrointestinal tract that usually treated clinically with chemotherapeutic agents, whereas agents can cause severe toxicity, which brings great pain to patients. Therefore, finding effective adjuvant for chemotherapy crucial. Methods In this study, CRC mouse model was successfully constructed using AOM/DSS, and treatment carried out by probiotic Bifidobacterium longum SX-1326 ( B. SX-1326) in combination irinotecan. Combining various techniques of modern biomedical research, such as Hematoxylin Eosin (H&E), Immunohistochemistry (IHC), Western blotting 16S rDNA sequencing, we intend elucidate effect mechanism improving anticancer efficacy reducing side effects on different levels molecules, animals, bacteria. Results Our results showed enhanced expression Cleaved Caspase-3 (M vs. U = p < 0.01) down-regulated level B-cell lymphoma-2 (Bcl-2) through up-regulation p53 signaling pathway mice, resulted an Moreover, also able regulate gut-brain-axis (GBA) restoring damaged enterochromaffin cells, release 5-hydroxytryptamine (5-HT) brain tissue (I 89.26 75.03, 0.05), further alleviating adverse nausea vomiting. addition, reversed dysbiosis mice increasing Dehalobacterium , Ruminnococcus Mucispirillum . And alleviated colorectal inflammation downregulating TLR4/MyD88/NF-κB pathway. Conclusions conclusion, our work reveals has favorable irinotecan amelioration post-chemotherapy effects, provides theoretical basis data safe efficient adjuvant.
Язык: Английский
Процитировано
12
Annals of Hepatology, Год журнала: 2025, Номер unknown, С. 101777 - 101777
Опубликована: Янв. 1, 2025
Non-alcoholic fatty liver disease (NAFLD), now recognized as metabolic dysfunction-associated steatotic (MASLD), represents a significant and escalating global health challenge. Its prevalence is intricately linked to obesity, insulin resistance, other components of the syndrome. As our comprehension MASLD deepens, it has become evident that this condition extends beyond liver, embodying complex, multi-systemic with hepatic manifestations mirror broader landscape. This comprehensive review delves into critical interplay between gut-liver axis oxidative stress, elucidating their pivotal roles in etiology progression MASLD. Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger stress through enhanced ROS production hepatocytes Kupffer cells, leading mitochondrial dysfunction lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation endotoxins like LPS, which activate inflammatory pathways TLR4 signaling promote via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB Nrf2 serve crucial mediators axis, regulating responses orchestrating antioxidant defenses; (4) Oxidative stress-induced damage function creates destructive feedback loop, further exacerbating inflammation progression. These findings highlight complex interrelationship pathogenesis, suggesting potential therapeutic targets for management.
Язык: Английский
Процитировано
1
Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
1
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 197, С. 114243 - 114243
Опубликована: Март 2, 2024
In vitro models that mimic the pathophysiology in vivo are important tools to study mechanisms of disease and assess pharmacology toxicity drugs. this work, we report development a novel model intestinal inflammation. This is based on co-culture epithelial Caco-2 cells murine J774A.1 macrophages. The shown barrier both healthy inflamed state. state, without external stimulation, were co-cultured one system affecting integrity inducing release cytokines from To intestine, primed with an optimised cytokine cocktail (TNF-⍺, IFN-γ IL-1β) pre-exposed lipopolysaccharide (LPS) for 24 h before combining two cell lines into co-culture. these conditions, significant disruption increase pro-inflammatory (TNF-⍺ IL-6) levels released macrophages detected. data also show inflammation was temporary reversible upon removal inflammatory stimulus. new could be valuable tool investigating safety efficacy drugs context provides advantages over other reported terms cost simplicity.
Язык: Английский
Процитировано
7
Fish & Shellfish Immunology, Год журнала: 2024, Номер 152, С. 109785 - 109785
Опубликована: Июль 23, 2024
Язык: Английский
Процитировано
6
Environmental Research, Год журнала: 2024, Номер 249, С. 118437 - 118437
Опубликована: Фев. 10, 2024
The widespread prevalence of micro and nanoplastics in the environment raises concerns about their potential impact on human health. Recent evidence demonstrates presence blood tissues following ingestion inhalation, yet specific risks mechanisms nanoplastic toxicity remain inadequately understood. In this study, we aimed to explore molecular underlying at both systemic levels by analyzing transcriptomic/metabolomic responses signaling pathways intestines mice after oral administration nanoplastics. Transcriptome analysis nanoplastic-administered revealed a notable upregulation genes involved pro-inflammatory immune responses. addition, substantially reduced expression tight junction proteins, including occludin, zonula occluden-1, tricellulin, which are crucial for maintaining gut barrier integrity function. Importantly, increased permeability exacerbated dextran sulfate sodium-induced colitis. Further investigation into highlighted significant activation transsducer activator transcription (STAT)1 STAT6 administration, was line with elevation interferon JAK-STAT pathway signatures identified through transcriptome enrichment analysis. Additionally, consumption specifically induced nuclear factor kappa-B (NF-κB) extracellular signal-regulated kinase (ERK)1/2 intestines. Collectively, study identifies contributing adverse effects mediated intestine, providing novel insights pathophysiological consequences exposure.
Язык: Английский
Процитировано
5
European Journal of Clinical Investigation, Год журнала: 2024, Номер 54(7)
Опубликована: Апрель 18, 2024
Abstract Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a leading cause of end‐stage associated with increased mortality and cardiovascular disease. Obesity diabetes are the most important risk factors MASLD. It well‐established that obesity‐associated insulin resistance leads to situation tissue lipotoxicity characterized by an accumulation excess fat in non‐fat tissues such as liver, promoting development MASLD, its progression into metabolic steatohepatitis. Methods Here, we aimed review impact disrupted intestinal permeability, antimicrobial proteins bacterial endotoxin Results Conclusion Recent studies demonstrated obesity‐ obesogenic diets‐associated alterations microbiota along disruption barrier integrity, alteration and, consequence, enhanced translocation bloodstream might contribute this pathological process through impacting metabolism inflammation.
Язык: Английский
Процитировано
5