Heart rate variability as a biomarker in health and affective disorders: A perspective on neuroimaging studies

NeuroImage, Год журнала: 2019, Номер 202, С. 116072 - 116072

Опубликована: Авг. 3, 2019

Язык: Английский

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Gut microbiome patterns depending on children’s psychosocial stress: Reports versus biomarkers

Brain Behavior and Immunity, Год журнала: 2019, Номер 80, С. 751 - 762

Опубликована: Май 18, 2019

Язык: Английский

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Psychological and biological resilience modulates the effects of stress on epigenetic aging

Translational Psychiatry, Год журнала: 2021, Номер 11(1)

Опубликована: Ноя. 27, 2021

Язык: Английский

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FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention

Pharmacology & Therapeutics, Год журнала: 2020, Номер 215, С. 107623 - 107623

Опубликована: Июль 2, 2020

Язык: Английский

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Acute and chronic sleep deprivation in residents: Cognition and stress biomarkers

Medical Education, Год журнала: 2020, Номер 55(2), С. 174 - 184

Опубликована: Июль 22, 2020

Insufficient sleep affects circadian hormonal profiles and inflammatory markers may modulate attention, executive functioning decision-making. Medical professionals specifically resident physicians, who are involved in long-term nightshift schedules during their post-graduate training, prone to acute chronic deprivation disruption, putting them at risk for making medical errors. The aim of the study was evaluate impact acute-on-chronic disruption among residents on selected physiological cognitive measures.Thirty-three surgical were evaluated twice - baseline after a 26-hour shift. Eighteen young attending physicians did not engage served as controls once. Measures included morning cortisol high-sensitivity C-reactive protein (hs-CRP), computerised tests attention behaviour, Behaviour Rating Inventory Executive Function, risk-taking questionnaire Pittsburgh Sleep Quality Index.Residents, but attendings, reported deprivation. Residents exhibited reduced levels elevated hs-CRP levels, compared attendings. had impaired global function A with further residents' function. demonstrated increased impulsivity slower processing time than attendings differ tendencies which assessed separate cohort.In real-life setting, exhibit low-grade systemic inflammation (hs-CRP) HPA-axis Their curtailment is associated greater impulsivity, processing, Future research warranted understand how improving working schedule by increasing duration minimise short-term potential risks training.

Язык: Английский

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Strategies for Promotion of a Healthy Lifestyle in Clinical Settings: Pillars of Ideal Cardiovascular Health: A Science Advisory From the American Heart Association

Circulation, Год журнала: 2021, Номер 144(24)

Опубликована: Окт. 25, 2021

Engagement in healthy lifestyle behaviors is suboptimal. The vast majority of the US population does not meet current recommendations. A defined by consuming a dietary pattern, engaging regular physical activity, avoiding exposure to tobacco products, habitually attaining adequate amounts sleep, and managing stress levels. For all these health there are well-established guidelines; however, promotion clinical settings can be challenging. It critical overcome challenges because greater heathy practices effectively motivates initiates patient behavior change. 5A Model (assess, advise, agree, assist, arrange) was developed provide framework for counseling with requisite attention demands settings. In this science advisory, we present strategies, based on Model, that clinicians other care professionals use efficient lifestyle-related change patients at levels cardiovascular disease risk every visit. addition, discuss underlying role psychological well-being counseling, how leverage technologies when providing brief patient-centered counseling. Greater during routine clinician visits will contribute promoting health.

Язык: Английский

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Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia-Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity

Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 20

Опубликована: Май 27, 2022

Myocardial ischemia-reperfusion injury (MIRI) is a type of severe to the ischemic myocardium that can occur following recovery blood flow, and for which, there no effective treatment. Panaxatriol saponin (PTS), major active component P. notoginseng, has been used clinically treat ischemia-related encephalopathy due its antioxidant activity, but effect on cardiomyopathy underlying mechanism action still unclear. This study was performed investigate protective PTS against MIRI explore potential mechanisms. Hydrogen peroxide (H2O2) stimulate cardiomyocytes, mimic in vitro. Cell viability tested using CCK-8 method. The activity H9c2 rat cardiomyocyte cell line examined 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA). levels superoxide dismutase-1 (SOD1), SOD2, heme oxygenase (HO-1) were determined by Western blotting and/or immunofluorescence. antiapoptotic determined. In addition, mitochondrial permeability transition pore (mPTP) opening membrane (ΔΨm) changes assessed. Changes Keap1/Nrf2 activation evaluated analysis, molecular docking, immunoprecipitation. An vivo model established rats, myocardial infarct size measured 2,3,5-triphenyltetrazolium chloride (TTC) staining. enzyme activities ELISA or biochemical analyses. Furthermore, Nrf2 evaluated, regulatory apoptosis blocker, ML385. results showed ameliorated induced H2O2, characterized increased viability, decreased reactive oxygen species (ROS) production, promotion SOD1, HO1 expression. inhibited also reduced mPTP stabilized ΔΨm cells. Molecular docking immunoprecipitation revealed disrupt interaction directly blocking binding site Keap1 protein. vivo, area infarction attenuated pathological damage (I/R) rats. markers PTS. Finally, regulated nuclear translocation Nrf2, ML385 blocked therapeutic These suggested targeting activity.

Язык: Английский

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Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults

Nutrients, Год журнала: 2022, Номер 14(21), С. 4553 - 4553

Опубликована: Окт. 28, 2022

Inflammation plays a pivotal in the occurrence and development of coronary heart disease (CHD). We aim to investigate association between Dietary Inflammatory Index (DII) CHD present study. In this cross-sectional study, adult participants from National Health Nutrition Examination Survey (NHANES) (1999–2018) were enrolled. The social demographic information, lifestyle factors, blood biochemical measurements, dietary status all systematically collected. Multivariable logistic regression was adopted risk DII. Besides, restricted cubic spline (RCS) analysis used explore whether there nonlinear DII CHD. Subgroup stratified by sex, age, race/ethnicity, BMI conducted evaluate among different populations. A total 45,306 adults NHANES included. Compared with individuals without CHD, DIIs significantly elevated. positive observed multivariable after adjusting for education levels, smoking, drinking, diabetes, hypertension, body mass index (BMI). Results RCS suggested relationship addition, increment had greater impact on female compared male individuals. is closely associated For better prevention treatment more attention should be paid controlling inflammation.

Язык: Английский

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Psychological Stress and Heart Disease: Fact or Folklore?

The American Journal of Medicine, Год журнала: 2022, Номер 135(6), С. 688 - 696

Опубликована: Март 9, 2022

Abstract

For at least a few centuries, if not millennia, psychological stress has been popularly believed to contribute heart disease. Does really disease? Are anecdotal, patient, and lay press reports that angina, attack, even cardiac death are caused by based on fact, or they just folklore? In this review, the study data supporting associations between cardiovascular risk, as well potential mechanisms which might disease precipitate myocardial ischemia infarction, critically reviewed summarized.

Язык: Английский

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New Progress in Early Diagnosis of Atherosclerosis

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(16), С. 8939 - 8939

Опубликована: Авг. 11, 2022

Coronary atherosclerosis is a potentially chronic circulatory condition that endangers human health. The biological cause underpinning cardiovascular disease coronary atherosclerosis, and acute events can develop due to thrombosis, platelet aggregation, unstable atherosclerotic plaque rupture. progressive, three specific changes appear, with fat spots stripes, thin-walled fiber then complex in arteries. progression severity of are correlated various levels calcium accumulation the artery. therapy diagnosis benefit from initial assessment size degree calcification. This article will discuss new progress early terms aspects: imaging, gene protein markers, trace elements. study intends present latest methods for diagnosing patients through literature review.

Язык: Английский

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