Validation of the 2024 European Association for the Study of Obesity diagnostic criteria: A comprehensive assessment of obesity‐related mortality risks

Diabetes Obesity and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Aims Obesity is a global public health challenge, and the traditional WHO‐proposed diagnostic criteria based on body mass index (BMI) often fail to fully assess related risks. The European Association for Study of (EASO) has proposed new that combine BMI, waist‐to‐height ratio (WtHR) complications more accurately evaluate obesity‐related Materials Methods This study utilized data from National Health Nutrition Examination Survey database, covering years 1999–2018. validated EASO diagnosing obesity, defined as BMI ≥25 kg/m 2 , WtHR ≥0.5 presence 12 complications. associations between obesity mortality were assessed using Kaplan–Meier survival curves Cox proportional hazards regression analyses. Mediation analysis was conducted explore potential mechanisms by which impacts patient prognosis. Results A total 39 066 participants included, with mean age 43.6 years; 51.3% male. Over median follow‐up period 141 months, 3708 deaths recorded. prevalence 63.04% according criteria. rate ≥30 only 35.55%. achieved C‐index 0.5549, surpasses predictive accuracy criterion, 0.5265. indicated when criterion diagnose it associated all‐cause cardiovascular disease (CVD)‐related mortality, but did not predict cancer‐related mortality. diagnosed significantly an increased risk (hazard [HR] 95% confidence interval [CI]: 1.13 [1.02, 1.24]), CVD (HR CI: 1.48 [1.20, 1.83]) cancer 1.26 [1.03, 1.54]). When simplified any top five (diabetes mellitus, hypertension, CVD, metabolic syndrome ageing) criteria, had highest (0.612), remained independent prognostic factor poor overall CI mortality: 1.41 [1.26, 1.58], HR 2.08 [1.61, 2.68] 1.32 [1.06, 1.65]). Conclusions confirms value EASO, suggesting these offer accurate assessment

Язык: Английский

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Weight-adjusted waist index shows superior detection of coronary artery disease than body mass index in NHANES 1999–2020

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 27, 2025

Coronary artery disease (CAD) is a leading cause of morbidity and mortality globally, highlighting the need for improved risk assessment tools. Traditional measures like body mass index (BMI) do not fully capture associated with fat distribution. The weight-adjusted waist (WWI) has emerged as potential anthropometric measure that may provide more precise evaluation central adiposity its cardiovascular risks. We analyzed data from 49,240 participants in National Health Nutrition Examination Survey (NHANES) 1999 to 2020. Participants were stratified into quartiles based on WWI: Q1 (WWI < 10.43), Q2 (10.43 ≤ WWI 10.99), Q3 (10.99 11.56), Q4 ≥ 11.56). primary outcome was self-reported coronary (CAD). Multivariate logistic regression, generalized additive models, analyses conducted. predictive performance versus CAD assessed using receiver operating characteristic (ROC) curves, differences area under curve (AUC) evaluated by DeLong's test. regression analysis showed positive association between prevalence, which persisted after adjusting confounding variables. Higher increased CAD, Group 4 showing highest compared 1 (OR 2.06, 95% CI 1.37–3.09, P 0.001). This relationship observed BMI risk. Subgroup revealed prevalence pronounced aged 60 years (P interaction ROC demonstrated had superior ability (AUC 0.694 vs. 0.547, De-long test stronger US population, this particularly among younger adults. Longitudinal studies are needed establish relationship.

Язык: Английский

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NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 12, 2024

NOD-like receptor protein 3 (NLRP3) inflammasome is an intracellular sensing complex that possesses NACHT, leucine-rich repeat, and pyrin domain, playing a crucial role in innate immunity. Activation of the NLRP3 leads to production pro-inflammatory cellular contents, such as interleukin (IL)-1β IL-18, induction inflammatory cell death known pyroptosis, thereby amplifying or sustaining inflammation. While balanced response beneficial for resolving damage promoting tissue healing, excessive activation pyroptosis can have harmful effects. The involvement has been observed various cardiovascular diseases (CVD). Indeed, its associated are closely linked key risk factors including hyperlipidemia, diabetes, hypertension, obesity, hyperhomocysteinemia. Exercise compared with medicine highly effective measure both preventing treating CVD. Interestingly, emerging evidence suggests exercise improves CVD inhibits activity pyroptosis. In this review, mechanisms pathogenic critically discussed. Importantly, purpose emphasize managing by suppressing proposes it foundation developing novel treatment strategies.

Язык: Английский

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Effectiveness of retro and forward walking on cardiac autonomic function, cardiorespiratory fitness, and body composition in overweight female university students: a randomized-controlled trial

Sport Sciences for Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

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Impact of Excess Adiposity on Cardiorespiratory Fitness in Children and Adolescents with Kawasaki Disease

Life, Год журнала: 2025, Номер 15(2), С. 264 - 264

Опубликована: Фев. 10, 2025

(1) Background: To assess the impact of excessive body fat on cardiorespiratory fitness (CRF) and coronary artery health in children adolescents following acute Kawasaki disease (KD-CA). (2) Methods: A retrospective study KD-CA patients (ages 8–16) who completed cardiopulmonary exercise testing (CPET) last five years. Participants were classified based mass index (BMI) (FMI) into normal adiposity groups. Coronary (CA) Z-scores calculated using Lambda-Mu-Sigma method, with peak VO2 (peak Z-score) derived from a database Hong Kong Chinese adolescents. Primary outcomes included Z-score, Max-Z (maximum CA Z-score), anaerobic threshold metabolic equivalent (AT MET), MET, pulse oxygen. Statistical analyses conducted to evaluate differences across (3) Results: total 112 (mean age: 11.71 ± 2.54 years). The mean Z-score was −0.63 0.98. BMI FMI had significantly higher oxygen levels compared those (both p < 0.001). Additionally, showed AT (p = 0.049), lower 0.026) than participants. Boys, especially adiposity, superior oxygen, girls. (4) Conclusions: Excessive is associated reduced CRF elevated Max Z-score. These findings highlight need monitor composition optimize cardiovascular this population.

Язык: Английский

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Association between non-highdensity lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular-kidney-metabolic syndrome: evidence from NHANES 2001–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 28, 2025

Objective This research is to analyze the connection between NHHR and CKD occurrence using NHANES from 2001 2018. It will evaluate feasibility of as a tool for predicting CKM syndrome offer valuable insights personalized treatment approaches within U.S. population. Methods Data 16,575 individuals aged 20 69 years were analyzed, having excluded those who pregnant with incomplete data. was characterized by simultaneous presence Cardiometabolic Syndrome (CMS). For statistical analysis, weighted logistic regression models applied, accounting variables such age, gender, ethnicity, educational background, marital status, lifestyle factors, preexisting health conditions. Differently, restricted cubic splines (RCS) applied investigate any possible nonlinear relationships in study. Results The revealed that more prevalent among 60 older, women representing 55.36% affected. Additionally, levels notably elevated patients when compared without ( p &lt; 0.0001). As increased, prevalence also rose, highest quartile (Q4: 36.06%). A positive indicated multivariable regression, especially upper quartiles (Q3 Q4). Moreover, RCS analysis displayed noteworthy occurrence. subgroup uncovered significant interactions influenced BMI Hypertension. Conclusion With rising global syndrome, early identification high-risk could inform targeted prevention intervention strategies. Future should focus on validating diverse populations exploring its clinical utility, well examining relationship other biomarkers metabolic dysfunction better understand syndrome’s complex pathophysiology.

Язык: Английский

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Pathophysiology of Maternal Obesity and Hypertension in Pregnancy

Journal of Cardiovascular Development and Disease, Год журнала: 2025, Номер 12(3), С. 91 - 91

Опубликована: Март 3, 2025

Obesity is one of the biggest health problems in 21st century and leading disorder amongst women fertile age. Maternal obesity associated with several adverse maternal fetal outcomes. In this group women, risk for development hypertensive disorders pregnancy (HDPs), such as gestational hypertension (GH) pre-eclampsia (PE), increased. fact, there a linear association between an increase pre-pregnancy body mass index (BMI) PE. Excessive weight gain during also related to PE GH. The role pathophysiology HDP complex most likely due interaction factors that cause state poor cardiometabolic health. Adipokines seem have central development, especially Hypoadiponectinemia, hyperleptinemia, insulin resistance (IR), proinflammatory are metabolic disturbances pathogenesis, contributing its by inducing endothelial dysfunction. Hypertriglyceridemia suggested be part disease mechanisms HDP. Therefore, review seeks explore scientific literature assess complications

Язык: Английский

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Cardiorespiratory fitness and health in children and adolescents: an overview of systematic reviews with meta-analyses representing over 125 000 observations covering 33 health-related outcomes

British Journal of Sports Medicine, Год журнала: 2025, Номер unknown, С. bjsports - 109184

Опубликована: Март 18, 2025

Objective To synthesise data on the associations between cardiorespiratory fitness (CRF) and health in children adolescents, evaluate certainty of evidence identify knowledge gaps. Design An overview systematic reviews with meta-analyses. Results were pooled using forest plots evaluated GRADE. Data sources Medline, Embase, Scopus, CINAHL SPORTDiscus searched from January 2002 to March 2024. Eligibility criteria for selected studies Systematic meta-analyses exploring CRF adolescents aged <18 years. From 9062 records identified, 14 included. Meta-analysed 125 164 observations covering 33 outcomes compiled, showing favourable (n=26) or null (n=7) CRF. Among general populations, weak-to-moderate, links indicators anthropometry adiposity, cardiometabolic vascular health, mental well-being. clinical was lower participants a condition compared healthy controls, largest difference newly diagnosed cancer (mean difference=−19.6 mL/kg/min; 95%CI: −21.4,–17.8). Patients cystic fibrosis had greater risk all-cause mortality when comparing low vs. high (relative risk=4.9; 1.1, 22.1). The ranged very moderate. Conclusion shows promising numerous paediatric though calls further research. High-quality longitudinal is warranted confirm findings investigate predictive role childhood future health.

Язык: Английский

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In‐Hospital Outcomes in Patients With Acute Myocardial Infarction and No Standard Modifiable Cardiovascular Risk Factors Across Varying Body Mass Index: Findings From the CCC‐ACS Project

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Background Individuals who present with acute myocardial infarction in the absence of standard modifiable cardiovascular risk factors (ie, SMuRF‐less) seem to have a significantly increased mortality; however, it remains unclear whether “SMuRF paradox” would be influenced by patients' baseline body mass index (BMI) status. Methods Using data from CCC‐ACS (Improving Care for Cardiovascular Disease China–Acute Coronary Syndrome) project November 2014 July 2019, we analyzed patients and without SMuRFs categorized their BMI as underweight (<18.5 kg/m 2 ), normal weight (18.5–24 overweight (24–28 obese (>28 ). The primary outcome was in‐hospital all‐cause mortality. Multivariable logistic regression models were used estimate BMI‐stratified associations between SMuRF‐less status outcomes. Results study included 44 538 first‐presentation infarction, whom 4454 SMuRF‐less. incidence SMuRF‐lessness declined 16.2% 6.5% category, prevailed more frequently among women older people regardless Patients had significant increase mortality than ≥1 SMuRF (adjusted odds ratio [OR], 1.750 [95% CI, 1.057–2.896], P <0.001). highest rate observed group (3.5%). Considering obesity reference group, exhibited OR, 3.854 2.130–6.973], Conclusions Among compared those SMuRF, higher mortality, especially underweight, whereas survival most favorable obesity. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT0230661.

Язык: Английский

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Liver at crossroads: unraveling the links between obesity, chronic liver diseases, and the mysterious obesity paradox

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 14, 2024

Obesity is a global health issue that intricately linked to the development and progression of chronic liver disease (CLD). This bidirectional connection, coupled with obesity paradox (OP), presents management dilemma. The established influence on (CLD) surpassed by liver's impact onset advancement obesity. Patients CLD always experience increased energy expenditure, reduced appetite, low protein synthesis, all which might lead weight loss. However, metabolic disturbances, hormonal imbalances, inflammatory signaling, immobility, drugs, alterations in nutrient metabolism can contribute exacerbation Despite propagation OP concept, none guidelines has changed, recommending being overweight. Research bias confounders be lifebuoy explanation. Additionally, overlooking lethal morbidities for survival benefits full suffering seems an illogical idea. Therefore, rather than endorsing overweight status, emphasis should placed improving cardiorespiratory fitness preventing sarcopenia achieve better outcomes patients CLD. Accordingly, complex interplay between obesity, CLD, concept requires sophisticated individualized approach. Maximizing mitigating considered essential strategies attaining most favourable

Язык: Английский

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