Scientific Reports,
Год журнала:
2021,
Номер
11(1)
Опубликована: Июнь 14, 2021
Mesenchymal
stromal/stem
cells
(MSCs)
are
currently
being
used
in
clinical
trials
as
proposed
treatments
for
a
large
range
of
genetic,
immunological,
orthopaedic,
cardiovascular,
endocrine
and
neurological
disorders.
MSCs
potent
anti-inflammatory
mediators
which
considered
immune
evasive
employ
secreted
vesicles
to
communicate
repair
damaged
tissue.
Despite
their
prolific
use
therapy,
sex
specific
mechanism
action
is
rarely
potential
confounding
factor
use.
The
purpose
this
study
was
examine
the
potency
functionality
both
female
male
adipose
derived
order
gain
further
insights
into
donor
selection.
Methods
MSC
were
expanded
passage
4,
secretome
harvested
stored
at
-
80c.
To
assess
also
primed
assessed
via
functional
assays,
ELISA,
multiplex
immunophenotyping.
Results
Female
(fMSC),
consistently
suppressed
Peripheral
blood
mononuclear
cell
(PBMC)
proliferation
significantly
(p
<
0.0001)
more
than
(mMSC).
In
co-culture
mPBMCs,
showed
60.7
±
15.6%
suppression
with
fMSCs
compared
22.5
13.6%
mMSCs.
Similarly,
fPBMCs
by
67.9
10.4%
29.4
9.3%
enhanced
immunosuppression
attributed
production
higher
concentrations
such
IDO1
(3301
pg/mL
vs
1699
pg/mL)
perhaps
others
including
IL-1RA
(1025
701
pg/mL),
PGE-2
(6142
2448
prolonged
expression
VCAM-1
post
activation
relative
contrast,
mMSCs
produces
inflammatory
G-CSF
(806
503
pg/mL).
Moreover,
correlated
fMSCs,
but
not
induced
downregulation
IL-2
receptor
sustained
early
T
marker,
CD69
PBMCs
highlighting
differences
immunomodulation
potentials
between
sexes.
Conclusion
conclusion,
our
data
shows
that
vitro
counterparts.
inability
match
driven
microenvironment
advantage
evident
likely
red
flag
when
using
allogeneic
therapeutic
disease
states.
Diabetes,
Год журнала:
2020,
Номер
69(9), С. 1857 - 1863
Опубликована: Июль 15, 2020
Coronavirus
disease
2019
(COVID-19)
is
a
novel
threat
that
seems
to
result
from
the
collusion
between
new
pandemic
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
and
an
existing
metabolic
driven
by
obesity.
This
Perspective
explores
evolving
epidemiological,
clinical,
biological,
molecular
evidence
propose
unfolding
paradigm
in
which
old
age,
chronic
(such
as
obesity,
type
diabetes,
syndrome),
male
biological
sex
produce
deadly
symbiosis
dysregulated
immunometabolism
systemic
inflammation
intensifies
virally
induced
hyperinflammation
associated
with
SARS-CoV-2
infection.
It
intended
inspire
research
directions
stimulate
funding
this
field.
Journal of Endocrinological Investigation,
Год журнала:
2023,
Номер
47(2), С. 299 - 306
Опубликована: Сен. 23, 2023
Abstract
Purpose
There
is
a
growing
awareness
of
the
importance
understanding
gender
differences
in
obesity.
The
aim
this
short
review
was
to
revise
current
evidence
on
anthropometric
characteristics
and
nutritional
pharmacological
aspects
obesity
from
perspective.
Methods
A
literature
search
within
PubMed
performed.
Selected
publications
related
were
reviewed.
Results
prevalence
among
men
higher
than
women,
but
women
have
percentage
body
fat
content
compared
men,
appears
be
an
important
factor
manifestation
central
(android)
or
peripheral
(gynoid)
In
addition,
while
most
clinical
trials,
are
still
underrepresented,
registration
trials
anti-obesity
drugs,
commonly
up-represented
gender-specific
analysis
uncommon.
Considering
that
adipose
tissue
one
factors
affecting
volume
distribution
many
mainly
lipophilic
might
expected
pharmacokinetics
pharmacodynamics
drugs.
Indeed,
although
Liraglutide
3
mg,
long-acting
glucagon-like
peptide-1
receptor
agonist,
naltrexone/bupropion
display
properties,
currently,
gender–dose
adjustment
for
both
these
drugs
administration
not
recommended.
despite
predicted
responders
treatment
offer
substantial
opportunities
efficient
use,
especially
expensive
new
therapies,
such
as
data
identify
early
yet
been
investigated.
Finally,
bariatric
surgery
disparity
reflects
healthcare
practices.
Weight
loss
similar,
differing
effects:
need
more
correction
face
psychology
challenges;
worse
physiology
fewer
comorbidity
improvements.
Conclusion
Gender
exist
phenotype,
distribution,
drug
efficacy,
trial
representation,
different
secondary
effects
surgery.
variable
analysis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1588 - 1588
Опубликована: Янв. 13, 2023
Metabolic
syndrome
(Mets)
is
a
clinical
condition
characterized
by
cluster
of
major
risk
factors
for
cardiovascular
disease
(CVD)
and
type
2
diabetes:
proatherogenic
dyslipidemia,
elevated
blood
pressure,
dysglycemia,
abdominal
obesity.
Each
factor
has
an
independent
effect,
but,
when
aggregated,
they
become
synergistic,
doubling
the
developing
diseases
causing
1.5-fold
increase
in
all-cause
mortality.
We
will
highlight
gender
differences
epidemiology,
etiology,
pathophysiology,
expression
aforementioned
Mets
components.
Moreover,
we
discuss
new
biochemical
markers
metabolic
risk.
Abstract
Studying
circadian
rhythms
in
most
human
tissues
is
hampered
by
difficulty
collecting
serial
samples.
Here
we
reveal
the
transcriptome
and
metabolic
pathways
of
white
adipose
tissue.
Subcutaneous
tissue
was
taken
from
seven
healthy
males
under
highly
controlled
‘constant
routine’
conditions.
Five
biopsies
per
participant
were
at
six-hourly
intervals
for
microarray
analysis
silico
integrative
modelling.
We
identified
837
transcripts
exhibiting
expression
profiles
(2%
41619
transcript
targeting
probes
on
array),
with
clear
separation
peaking
morning
(258
probes)
evening
(579
probes).
There
only
partial
overlap
our
rhythmic
published
animal
blood
data.
Morning-peaking
associated
regulation
gene
expression,
nitrogen
compound
metabolism,
nucleic
acid
biology;
evening-peaking
organic
cofactor
metabolism
redox
activity.
In
pathway
further
indicated
lipid
metabolism;
it
also
predicted
variation
key
such
as
citric
cycle
branched
chain
amino
degradation.
summary,
vivo
exist
multiple
pathways,
including
those
involved
core
aspects
cellular
biochemistry.
Obesity Surgery,
Год журнала:
2020,
Номер
30(12), С. 5086 - 5100
Опубликована: Окт. 6, 2020
Abstract
Emerging
evidence
highlights
that
dysfunction
of
adipose
tissue
contributes
to
impaired
insulin
sensitivity
and
systemic
metabolic
deterioration
in
obese
state.
Of
note,
adipocyte
hypertrophy
serves
as
a
critical
event
which
associates
closely
with
dysfunction.
An
increase
cell
size
exacerbates
hypoxia
inflammation
well
excessive
collagen
deposition,
finally
leading
dysregulation.
Specific
mechanisms
include
dysregulated
differentiation
maturation
preadipocytes,
enlargement
lipid
droplets,
abnormal
osmolarity
sensors.
Also,
weight
loss
therapies
exert
profound
influence
on
size.
Here,
we
summarize
the
role
development
disturbances.
Future
studies
are
required
establish
standard
criterion
measurement
better
clarify
impact
changes
homeostasis.
Adipose,
or
fat,
tissue
(AT)
was
once
considered
an
inert
that
primarily
existed
to
store
lipids,
and
not
historically
recognized
as
important
organ
in
the
regulation
maintenance
of
health.
With
rise
obesity
more
rigorous
research,
AT
is
now
a
highly
complex
metabolic
involved
host
physiological
functions,
including
glucose
homeostasis
multitude
endocrine
capabilities.
dysfunction
has
been
implicated
several
disease
states,
most
notably
obesity,
syndrome
type
2
diabetes.
The
study
provided
useful
insight
developing
strategies
combat
these
prevalent
diseases.
This
review
highlights
major
functions
adipose
consequences
can
occur
when
disruption
leads
systemic
dysfunction.
We
conducted
a
systematic
review
and
meta-analysis
of
the
associations
between
prenatal
exposure
to
persistent
organic
pollutants
(POPs)
childhood
obesity.
focused
on
organochlorines
(dichlorodiphenyltrichloroethane
[DDT],
dichlorodiphenyldichloroethylene
[DDE],
hexachlorobenzene
[HCB],
polychlorinated
biphenyls
[PCBs]),
perfluoroalkyl
polyfluoroalkyl
substances
(PFAS),
polybrominated
diphenyl
ethers
(PBDEs)
that
are
POPs
more
widely
studied
in
environmental
birth
cohorts
so
far.
search
two
databases
(PubMed
Embase)
through
July/09/2021
identified
33
studies
reporting
with
organochlorine
exposure,
21
PFAS,
five
PBDEs.
qualitative
review.
Additionally,
we
performed
random-effects
meta-analyses
POP
exposures,
data
estimates
from
at
least
three
prospective
studies,
BMI-z.
Prenatal
DDE
HCB
levels
were
associated
higher
BMI
z-score
(beta:
0.12,
95%
CI:
0.03,
0.21;
I
