Exploring the Link between Inflammatory Biomarkers and Adipometrics in Healthy Young Adults Aged 20–35 Years

Nutrients, Год журнала: 2024, Номер 16(2), С. 257 - 257

Опубликована: Янв. 15, 2024

Obesity and aging are associated with an inflammatory state, which represents the common background for a wide range of diseases. This study aims to explore correlation between hsCRP, IL-1β, IL-6, TNF-α, IFN-γ, white blood cell count (WBC) adipometrics (arm, waist, hip circumferences: AC, WC, HC; total body fat mass: TBFM, visceral level: VFL, mass index: BMI; waist/hip ratio: WHR; waist/height WHtR) in young healthy adults aged 20-35 years old. The subjects were divided by BMI into overweight/obesity (OW/OB) group normal weight (NW) group, hsCRP level Group 1 (<1 mg/L), 2 (≥1-2.99 3 (≥3 mg/L). concentration all biomarkers was significantly higher OW/OB compared NW exception IL-1β. Significant positive correlations found WBC, adipometrics; IL-6 WHR, WHtR, BMI, VFL; IFN-γ HC, TBFM. IL-1β correlates positively WHR VFL. In Groups 1-3, differences showed significant differences. Subclinical inflammation persists association being overweight obese

Язык: Английский

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Body roundness index as a predictor of all-cause and cardiovascular mortality in patients with diabetes and prediabetes

Diabetes Research and Clinical Practice, Год журнала: 2024, Номер 219, С. 111958 - 111958

Опубликована: Дек. 13, 2024

Язык: Английский

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Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(9), С. 3341 - 3341

Опубликована: Май 8, 2023

Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure commonly ensues in patients with severe and obese phenotype of is now commonplace clinical practice. Severe share congruent cardiovascular, immune, renal derangements that make it difficult ascertain whether convergence two highly prevalent conditions or enables development progression syndrome failure. Nevertheless, provides a unique opportunity assess sustained sizeable loss excess body weight via metabolic bariatric surgery reverses concentric left ventricular remodeling display.

Язык: Английский

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Cardiovascular Disease Risk Reduction and Body Mass Index

Current Hypertension Reports, Год журнала: 2022, Номер 24(11), С. 535 - 546

Опубликована: Июль 5, 2022

Язык: Английский

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The lipidomic and inflammatory profiles of visceral and subcutaneous adipose tissues are distinctly regulated by the SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114535 - 114535

Опубликована: Март 14, 2023

The pharmacological inhibition of sodium-glucose cotransporter 2 (SGLT2) has emerged as a treatment for patients with type diabetes mellitus (T2DM), cardiovascular disease and/or other metabolic disturbances, although some the mechanisms implicated in their beneficial effects are unknown. SGLT2 inhibitor (SGLT2i) empagliflozin been suggested regulator adiposity, energy metabolism, and systemic inflammation adipose tissue. aim our study was to evaluate impact 6-week-empagliflozin on lipidome visceral (VAT) subcutaneous tissue (SAT) from diabetic obese Zucker Diabetic Fatty (ZDF) rats using an untargeted metabolomics approach. We found that increases content diglycerides oxidized fatty acids (FA) VAT, while SAT, it decreases levels several lysophospholipids phosphatidylcholines. Empagliflozin also reduces expression cytokines interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha (TNFα), monocyte-chemotactic protein-1 (MCP-1) IL-10, Cd86 Cd163 M1 M2 macrophage markers no changes except decrease IL-1β. shows effect lipolysis increasing hormone-sensitive lipase (HSL) SAT VAT triglyceride (ATGL) together FA transporter cluster differentiation 36 (CD36). In conclusion, data highlighted differences lipidomes, inflammatory profiles lipolytic function, which suggest distinct metabolism these two white depots after treatment.

Язык: Английский

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Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity

International Journal of Obesity, Год журнала: 2023, Номер 48(4), С. 523 - 532

Опубликована: Дек. 22, 2023

Язык: Английский

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Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension

Hypertension Research, Год журнала: 2024, Номер 47(8), С. 2157 - 2171

Опубликована: Май 21, 2024

Язык: Английский

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Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Май 25, 2024

The stomach-derived hormone ghrelin regulates essential physiological functions. receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in feeding behaviors and diet-induced obesity (DIO). Here, we effects long-term (12-month) high-fat (HFD) versus regular diet on obesity-related measures global GHSR-KO wild-type (WT) Wistar male female rats. Our main findings are that protects against DIO decreases food intake during HFD but not increases thermogenesis brain glucose uptake rats modifies metabolism sex-specific manner, as assessed with small animal positron emission tomography. We use RNA-sequencing show have upregulated expression genes responsible for fat oxidation brown adipose tissue. Central administration novel inverse agonist, PF-5190457, attenuates ghrelin-induced intake, only male, mice. HFD-induced binge-like eating is reduced by agonism both sexes. results support promising target new pharmacotherapies obesity.

Язык: Английский

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The adventitia in arterial development, remodeling, and hypertension

Biochemical Pharmacology, Год журнала: 2022, Номер 205, С. 115259 - 115259

Опубликована: Сен. 21, 2022

Язык: Английский

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Interdialytic home systolic blood pressure variability increases all‐cause mortality in hemodialysis patients

Clinical Cardiology, Год журнала: 2024, Номер 47(4)

Опубликована: Март 29, 2024

Abstract Background The association between Interdialytic home blood pressure variability (BPV) and the prognosis of patients undergoing maintenance hemodialysis (MHD) largely unknown. Hypothesis We proposed hypothesis that interdialytic BPV exert effect on cardiac all‐cause mortality among individuals MHD. Methods A total 158 receiving MHD at unit Wuhan Fourth Hospital December 2019 August 2020 were included in this prospective cohort study. Patients divided into tertiles according to systolic (SBPV), primary endpoints death. Kaplan–Meier analysis was used assess relationship long‐term survival SBPV. In addition, Cox proportional hazards regression models identify risk factors contributing poor prognosis. Results death gradually increased SBPV (3.5% vs. 14.8% 19.2%, p for trend = .021; 11.5% 27.8% 44.2%, <.001). revealed compared Tertile 1, hazard ratios 2 3 3.13 ( .026) 3.24 .021), respectively, after adjustment a series covariates. Conclusions findings positive correlation elevated with

Язык: Английский

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