Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course

Multiple Sclerosis Journal, Год журнала: 2020, Номер 26(12), С. 1459 - 1469

Опубликована: Апрель 23, 2020

Objectives: To provide clinicians who treat multiple sclerosis (MS) patients with evidence-based or expert opinion–based recommendations for promoting exercise and lifestyle physical activity across disability levels. Methods: The National MS Society (“Society”) convened clinical research experts in the fields of MS, exercise, rehabilitation, to (1) reach consensus on optimal individuals at levels 0–9.0 Expanded Disability Status Scale (EDSS) (2) identify address barriers/facilitators participation. Recommendations: Based current evidence opinion, makes following recommendations, endorsed by Consortium Multiple Sclerosis Centers: Healthcare providers should endorse promote benefits/safety every person MS. Early evaluation a occupational therapist sport scientist, experienced (hereafter referred as “specialists”), is recommended establish an individualized and/or plan. Taking into account comorbidities symptom fluctuations, healthcare encourage ⩾150 min/week activity. Progress toward these targets be gradual, based person’s abilities, preferences, safety. If increases exercise/physical becomes more challenging, referrals specialists are essential ensure safe appropriate prescriptions. When mobility very limited, facilitated trained assistant.

Язык: Английский

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Advances in Neurodegenerative Diseases

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(5), С. 1709 - 1709

Опубликована: Фев. 21, 2023

Neurological disorders are the leading cause of physical and cognitive disability across globe, currently affecting approximately 15% worldwide population [...].

Язык: Английский

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Exercise as medicine in Parkinson’s disease

Journal of Neurology Neurosurgery & Psychiatry, Год журнала: 2024, Номер 95(11), С. 1077 - 1088

Опубликована: Фев. 28, 2024

Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while symptomatic treatments have limited effects in certain domains cause side effects. Identification of interventions that prevent, slow, halt mitigate the therefore pivotal. Exercise safe represents a cornerstone rehabilitation, but exercise may even more fundamental benefits could change clinical practice. In PD, existing knowledge base supports as (1) protective lifestyle factor preventing (ie, primary prevention), (2) potential disease-modifying therapy secondary prevention) (3) effective treatment tertiary prevention). Based on current evidence, paradigm shift proposed, stating should be individually prescribed medicine persons with at early stage, alongside conventional medical treatment.

Язык: Английский

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High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial

Multiple Sclerosis Journal, Год журнала: 2017, Номер 24(12), С. 1635 - 1644

Опубликована: Авг. 21, 2017

Background: Aerobic exercise can improve cognitive performance in healthy elderly people. Objective: The aim of this study was to investigate the influence a 3-week high-intensity aerobic programme (high-intensity training group (HIT)) on persons with multiple sclerosis (MS) compared standard (control (CT)). Methods: A total 60 MS (Expanded Disability Status Scale (EDSS): 1.0–6.5) were randomized HIT (3×/week for 20 minutes, including five 3-minute intervals at 80% peak oxygen uptake (VO 2-peak )) or CT (continuously 5×/week 30 minutes/session 65% VO ). Cognitive assessed using Brief International Assessment entry ( t 0 ) and discharge 1 Furthermore, , brain-derived neurotrophic factor, serotonin matrix metalloproteinases (MMP)-2 -9 measured. Results: Compared CT, significantly improved verbal memory. Significant improvements over time executive functions found both groups. Secondary outcomes indicated significant reduction MMP-2 only. Conclusion: represents promising strategy memory physical fitness MS. Further research is needed determine impact biomarkers

Язык: Английский

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Is Aerobic or Resistance Training the Most Effective Exercise Modality for Improving Lower Extremity Physical Function and Perceived Fatigue in People With Multiple Sclerosis? A Systematic Review and Meta-analysis

Archives of Physical Medicine and Rehabilitation, Год журнала: 2021, Номер 102(10), С. 2032 - 2048

Опубликована: Апрель 24, 2021

ObjectiveThe purpose of this systematic review was to investigate whether aerobic training (AT) or resistance (RT) is most effective in terms improving lower limb physical function and perceived fatigue persons with multiple sclerosis (PwMS).Data SourcesNine databases (MEDLINE, EMBASE, Cumulative Index Nursing Allied Health, Complementary Medicine Database, Physiotherapy Evidence SPORTDiscus, PsycINFO, Web Science, Scopus) were electronically searched April 2020.Study SelectionIncluded studies randomized controlled trials (RCTs) involving PwMS attending 1 2 exercise interventions: AT RT. Studies had include at least objective self-reported outcome extremity and/or fatigue.Data ExtractionData extracted using a customized spreadsheet, which included detailed information on patient characteristics, interventions, outcomes. The methodological quality the independently assessed by reviewers Tool for Assessment Study Quality Reporting Exercise rating scale.Data SynthesisTwenty-seven articles reporting data from 22 RCTS (AT=14, RT=8) including 966 PwMS. modalities found be equally short walk test (AT: effect size [ES]=0.33 [95% confidence interval (CI), −1.49 2.06]; RT: ES=0.27 CI, 0.07-0.47]) long performance ES=0.37 −0.04 0.78]; ES=0.36 −0.35 1.08]), as well reducing ES=−0.61 −1.10 −0.11]; ES=−0.41 −0.80 −0.02]). Findings other functional mobility tests along walking sparse inconclusive.ConclusionsAT RT appear highly Clinicians can thus use either modality target impairments these In future perspective, head-to-head are warranted. Future MS further encouraged adapt consensus “core battery” facilitate comparison results across modalities.

Язык: Английский

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Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression

Journal of Neurology, Год журнала: 2022, Номер 269(6), С. 2922 - 2940

Опубликована: Янв. 27, 2022

Abstract Background A moderate to high level of physical activity, including regular exercise, represents an established behavioral and rehabilitative approach for persons with multiple sclerosis (pwMS). Although being increasingly proposed limit disease activity progression, high-quality evidence is lacking. Objective The objective the study provide valuable information MS clinicians researchers by systematically evaluating current state (i) whether exercise interventions affect clinical measures progression in pwMS (i.e., EDSS, relapse rate, lesion load, brain volume, MSFC) (ii) how fitness interact these measures. Methods Literature search was conducted MEDLINE, EMBASE, CINAHL, SPORTDiscus. Evaluation quality done based on standards published American Academy Neurology. Results It likely that improves MSFC score, whereas EDSS volume are remain unchanged over intervention period. possible decreases rate. from cross-sectional studies indicate beneficial effects a or which, however, not corroborated quality. Conclusions (supportive) disease-modifying effect cannot be concluded. rather low existing RCTs underlines need conduct more well-designed assessing different as primary end points. major limitation short duration which limits meaningful exercise-induced most disability Findings difficult contextualize regarding importance due their solely associative character PROSPERO registration number CRD42020188774.

Язык: Английский

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“Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function

Sports Medicine, Год журнала: 2023, Номер 53(S1), С. 49 - 65

Опубликована: Июнь 27, 2023

There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices brain health and function. Creatine can increase stores, which may help explain some positive measures cognition memory, especially in aging adults or during times metabolic stress (i.e., sleep deprivation). Furthermore, has shown promise for improving outcome associated with muscular dystrophy, traumatic injury (including concussions children), depression, anxiety. However, whether any sex- age-related differences exist regard to function relatively unknown. The purpose this narrative review to: (1) provide an up-to-date summary discussion current body research focusing (2) discuss possible response bioenergetics, function, neurological diseases.

Язык: Английский

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The Potential of Transcranial Direct Current Stimulation (tDCS) in Improving Quality of Life in Patients with Multiple Sclerosis: A Review and Discussion of Mechanisms of Action

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 373 - 373

Опубликована: Янв. 9, 2025

Background/Objectives: Multiple sclerosis (MS) is the most prevalent incurable nontraumatic neurological disability in young individuals. It causes numerous symptoms, including tingling, fatigue, muscle spasms, cognitive deficits, and neuropsychiatric disorders. This disease significantly worsens quality of life (QoL), this dimension general functioning provides valuable information about effectiveness treatment well-being. There are psychological interventions that can improve QoL, but their number limited. Therefore, searching for new methods as effective safe possible ongoing. Methods: review examines potential transcranial direct current stimulation (tDCS) improving patients with MS. Searches were conducted PubMed/Medline, Research Gate, Cochrane databases. Results: The search yielded seven studies which QoL was a primary or secondary outcome. Stimulation protocols displayed heterogeneity, especially concerning choice site. Four demonstrated tDCS all (two) used anodal left DLPFC. motor cortex has produced mixed results. mechanisms action MS explained. These include improved synaptic plasticity, increased cerebral blood flow, salience network engagement through tDCS, reduction beta-amyloid deposition. limitations also detailed, recommendations future research made. Conclusions: While evidence limited, shown to some studies. Prefrontal appears promising, further recommended explore approach.

Язык: Английский

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Exploring Perceptions of Physical Activity in Individuals Newly Diagnosed with Multiple Sclerosis

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1199 - 1199

Опубликована: Фев. 12, 2025

Background: Physical activity is essential in enhancing the quality of life for individuals with multiple sclerosis (MS). However, there limited evidence regarding unique barriers newly diagnosed MS face. The purpose this qualitative study to understand perspectives persons about physical activity. Methods: Four focus groups were conducted (n = 12). Participants asked open-ended questions related and facilitators activity, knowledge surrounding they would find helpful, how best receive information track their progress. Results: themes generated from data: (1) lack leads fear aversion, (2) reimagining frustration, (3) navigating constraints a busy world, (4) accountability key maintaining presence barriers. findings used adapt an existing coaching intervention model increase engagement specifically soon after diagnosis. Conclusions: This underscores distinct challenges encountered by MS, most notably time imposed symptoms employment commitments. These highlight necessity developing tailored intervention, such as ENGAGE-MS, that prioritizes education, accessibility, adaptability maximize benefits develop long-term, sustainable behaviors.

Язык: Английский

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Präventive Neurologie – nie zu früh und nie zu spät

DGNeurologie, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

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