Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Язык: Английский
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Язык: Английский
Psicothema, Год журнала: 2024, Номер 36(4), С. 309 - 318
Опубликована: Янв. 1, 2024
Background:: Suicide is a preventable public health and social problem. Suicidal behavior complex multifactorial phenomenon whose characterization, assessment, prevention, intervention, postvention require comprehensive approach focused on the meaning in person’s life their suffering biographical, cultural context. It an extraordinarily variable over time highly dependent contextual elements. Method:: This editorial includes determinants of this phenomenon, key aspects linked to dehumanization healthcare settings, problems iatrogenic harm universal prevention programs for schoolchildren adolescents, good clinical practices collected scientific literature. Results:: The highlights importance research suicidal from any intervention level, whether educational, community, social, or health, as all are involved prevention. Conclusions:: goal help improve biographical circumstances people with behaviors meaningfulness lives. must be done through collective scaffolding which most vulnerable can ask when they need it, well guide themselves towards worth living.
Язык: Английский
Процитировано
7Health Education Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Objective: The aim of this study was to describe the strategies used by Canadian healthcare providers assist men in strengthening their intimate partner relationships. Design: Qualitative research study. Method: Data were collected through semi-structured individual interviews. Using interpretive descriptive methods, secondary analysis inductively identified 10 Canadian-based providers. Participants comprised six counsellors, one registered psychologist, associate certified coach, father support supervisor and programme facilitator. Result: Three thematic findings developed: (1) equipping with lifelong relationship skills; (2) knowing transforming masculinities; (3) understanding men’s experiences using trauma-informed care approaches. Theme 1 stressed importance attentively listening for cues, establishing dialogue expressing emotions meet needs. Emphasised need create safe spaces respect disclosures about previous experiences. 2 highlighted significance masculinities promote pro-social values identifying mobilising strengths assets. Providers explored attitudes masculinity created opportunities model transformative approaches towards equitable 3 emphasised better understand trauma order situate progress By acknowledging trauma, aimed undo harmful patterns emotional suppression facilitate healing. Conclusion: This identities working reflexivity, behaviour help-seeking
Язык: Английский
Процитировано
1Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 309 - 309
Опубликована: Фев. 23, 2025
Background: Depression is one of the most serious and common health problems among youth population responsible for initiation many diseases. As per World Health Organization, 3.8% suffers from mental depression, globally. The monoamine oxidase-A (MAO-A) enzyme degradation neurotransmitters leading to lower levels neurotransmitters. Methods: Chalcones (C1-C15) were synthesized by reacting substituted acetophenone with various benzaldehydes in a basic ethanolic solvent at 80 °C under microwave irradiation conditions. To compare reaction time product yield, conventional method synthesis chalcones was also performed. spectroscopically characterized screened initially inhibitory activities against MAO-A MAO-B. best active compounds undertaken IC50 determination followed reversibility inhibition analysis antioxidant assay. Moreover, silico molecular docking ADME pharmacokinetic investigations accomplished. Results: Most inhibited MAO-A, specifically, C14 C6 exhibited highest values 7.91 ± 0.08 μM 8.45 0.19 μM, respectively. Both these reversible displaying up 60% recovery enzymatic activity when diluted substrate (Tyramine). results study indicated scores −9.56 Kcal/mol (C14) −9.45 (C6) π-π stacking interaction crucial amino acid Trp-397. determined cross blood–brain barrier (BBB) displayed favorable gastrointestinal (GI) absorption. Further, assay demonstrated that possess modest free radical scavenging potential. Conclusions: This potential morpholine-substituted as promising pharmacophore development novel antidepressant lead compounds.
Язык: Английский
Процитировано
1Psychiatry Research, Год журнала: 2025, Номер 347, С. 116391 - 116391
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
1Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134505 - 134505
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
6Disease-a-Month, Год журнала: 2024, Номер 70(9), С. 101725 - 101725
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
4BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Июнь 11, 2024
Abstract Background Rates of self-harm and suicide are rising for young people globally many implicate social media in this problem. To address concern to increase the confidence adults communicate safely about with people, #chatsafe Guide Parents Carers was developed Australia. With significant uptake resource among Australian adults, aim current study update contextualise audiences 15 countries globally. improve relevance parents carers these countries, present sought understand concerns held by parents, prevention professionals around world topics explore extent which a such as would be helpful within their communities. Methods Seven focus groups were conducted via Zoom ( n = 40) from countries. Transcribed data coded thematically analysed using both inductive deductive processes. Results Six themes reported: (1) Two scary ‘S’ words; (2) Country culture impact who talks (or is silent) suicide; (3) The need protective ecosystem; (4) tool that can help worldwide; (5) should consider local context end users its (6) A range marketing dissemination strategies needed reach information. Findings informed contextualisation adult Conclusions findings underscore universal psychoeducation initiatives provide skills knowledge support mental health online offline, resources like #chastafe play an important role providing reliable information across cultures contexts.
Язык: Английский
Процитировано
4Journal of Affective Disorders, Год журнала: 2024, Номер 370, С. 328 - 336
Опубликована: Ноя. 5, 2024
Язык: Английский
Процитировано
4Journal of Affective Disorders, Год журнала: 2024, Номер 354, С. 642 - 648
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
3The Lancet Psychiatry, Год журнала: 2024, Номер 11(9), С. 671 - 672
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
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