medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 5, 2024
ABSTRACT
Nonfatal
suicidality
is
the
most
robust
predictor
of
suicide
death.
However,
only
∼10%
those
who
survive
an
attempt
go
on
to
die
by
suicide.
Moreover,
∼50%
deaths
occur
in
absence
prior
known
attempts,
suggesting
risks
other
than
nonfatal
need
be
identified.
We
studied
data
from
4,000
population-ascertained
and
26,191
population
controls
improve
understanding
leading
This
study
included
2,253
3,375
with
evidence
(SUI_SI/SB
CTL_SI/SB)
diagnostic
codes
natural
language
processing
electronic
health
records
notes.
Characteristics
these
groups
were
compared
1,669
suicides
no
SI/SB
(SUI_None)
22,816
lifetime
(CTL_None).
The
SUI_None
CTL_None
had
fewer
diagnoses
older
SUI_SI/SB
CTL_SI/SB.
Mental
far
less
common
both
groups;
mental
problems
associated
death
presence
SI/SB.
Physical
conversely
more
often
risk
Pending
replication,
results
indicate
highly
significant
clinical
differences
among
versus
without
Health Education Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Objective:
The
aim
of
this
study
was
to
describe
the
strategies
used
by
Canadian
healthcare
providers
assist
men
in
strengthening
their
intimate
partner
relationships.
Design:
Qualitative
research
study.
Method:
Data
were
collected
through
semi-structured
individual
interviews.
Using
interpretive
descriptive
methods,
secondary
analysis
inductively
identified
10
Canadian-based
providers.
Participants
comprised
six
counsellors,
one
registered
psychologist,
associate
certified
coach,
father
support
supervisor
and
programme
facilitator.
Result:
Three
thematic
findings
developed:
(1)
equipping
with
lifelong
relationship
skills;
(2)
knowing
transforming
masculinities;
(3)
understanding
men’s
experiences
using
trauma-informed
care
approaches.
Theme
1
stressed
importance
attentively
listening
for
cues,
establishing
dialogue
expressing
emotions
meet
needs.
Emphasised
need
create
safe
spaces
respect
disclosures
about
previous
experiences.
2
highlighted
significance
masculinities
promote
pro-social
values
identifying
mobilising
strengths
assets.
Providers
explored
attitudes
masculinity
created
opportunities
model
transformative
approaches
towards
equitable
3
emphasised
better
understand
trauma
order
situate
progress
By
acknowledging
trauma,
aimed
undo
harmful
patterns
emotional
suppression
facilitate
healing.
Conclusion:
This
identities
working
reflexivity,
behaviour
help-seeking
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: June 11, 2024
Abstract
Background
Rates
of
self-harm
and
suicide
are
rising
for
young
people
globally
many
implicate
social
media
in
this
problem.
To
address
concern
to
increase
the
confidence
adults
communicate
safely
about
with
people,
#chatsafe
Guide
Parents
Carers
was
developed
Australia.
With
significant
uptake
resource
among
Australian
adults,
aim
current
study
update
contextualise
audiences
15
countries
globally.
improve
relevance
parents
carers
these
countries,
present
sought
understand
concerns
held
by
parents,
prevention
professionals
around
world
topics
explore
extent
which
a
such
as
would
be
helpful
within
their
communities.
Methods
Seven
focus
groups
were
conducted
via
Zoom
(
n
=
40)
from
countries.
Transcribed
data
coded
thematically
analysed
using
both
inductive
deductive
processes.
Results
Six
themes
reported:
(1)
Two
scary
‘S’
words;
(2)
Country
culture
impact
who
talks
(or
is
silent)
suicide;
(3)
The
need
protective
ecosystem;
(4)
tool
that
can
help
worldwide;
(5)
should
consider
local
context
end
users
its
(6)
A
range
marketing
dissemination
strategies
needed
reach
information.
Findings
informed
contextualisation
adult
Conclusions
findings
underscore
universal
psychoeducation
initiatives
provide
skills
knowledge
support
mental
health
online
offline,
resources
like
#chastafe
play
an
important
role
providing
reliable
information
across
cultures
contexts.
Psicothema,
Journal Year:
2024,
Volume and Issue:
36(4), P. 309 - 318
Published: Jan. 1, 2024
Background::
Suicide
is
a
preventable
public
health
and
social
problem.
Suicidal
behavior
complex
multifactorial
phenomenon
whose
characterization,
assessment,
prevention,
intervention,
postvention
require
comprehensive
approach
focused
on
the
meaning
in
person’s
life
their
suffering
biographical,
cultural
context.
It
an
extraordinarily
variable
over
time
highly
dependent
contextual
elements.
Method::
This
editorial
includes
determinants
of
this
phenomenon,
key
aspects
linked
to
dehumanization
healthcare
settings,
problems
iatrogenic
harm
universal
prevention
programs
for
schoolchildren
adolescents,
good
clinical
practices
collected
scientific
literature.
Results::
The
highlights
importance
research
suicidal
from
any
intervention
level,
whether
educational,
community,
social,
or
health,
as
all
are
involved
prevention.
Conclusions::
goal
help
improve
biographical
circumstances
people
with
behaviors
meaningfulness
lives.
must
be
done
through
collective
scaffolding
which
most
vulnerable
can
ask
when
they
need
it,
well
guide
themselves
towards
worth
living.
World Journal of Psychiatry,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: Jan. 14, 2025
Suicide
is
defined
as
the
act
of
a
person
attempting
to
take
their
own
life
by
causing
death.
complex
phenomenon
that
influenced
multitude
factors,
including
psychosocial,
cultural,
and
religious
aspects,
well
genetic,
biochemical,
environmental
factors.
From
biochemical
perspective,
it
crucial
consider
communication
between
endocrine,
immune,
nervous
systems
when
studying
etiology
suicide.
Several
pathologies
involve
bidirectional
peripheral
activity
central
system
action
molecules
such
cytokines,
hormones,
neurotransmitters.
These
humoral
signals,
present
in
optimal
quantities,
are
responsible
for
maintaining
physiological
homeostasis,
mood
states.
Stress
elevates
cortisol
proinflammatory
cytokines
levels
alter
neurotransmitters
balance,
thereby
increasing
risk
developing
psychiatric
disorder
subsequently
suicidal
behavior.
This
review
provides
an
integrative
perspective
about
neurochemical,
immunological,
endocrinological
disturbances
associated
with
behavior,
particular
focus
on
those
alterations
may
serve
potential
markers
and/or
indicators
state
preceding
tragic
act.
Big Data and Cognitive Computing,
Journal Year:
2025,
Volume and Issue:
9(1), P. 16 - 16
Published: Jan. 20, 2025
As
suicide
rates
increase
globally,
there
is
a
growing
need
for
effective,
data-driven
methods
in
mental
health
monitoring.
This
study
leverages
advanced
artificial
intelligence
(AI),
particularly
natural
language
processing
(NLP)
and
machine
learning
(ML),
to
identify
suicidal
ideation
from
Twitter
data.
A
predictive
model
was
developed
process
social
media
posts
real
time,
using
NLP
sentiment
analysis
detect
textual
emotional
cues
associated
with
distress.
The
aims
potential
risks
accurately,
while
minimizing
false
positives,
offering
practical
tool
targeted
interventions.
achieved
notable
performance,
an
accuracy
of
85%,
precision
88%,
recall
83%
detecting
posts.
Advanced
preprocessing
techniques,
including
tokenization,
stemming,
feature
extraction
term
frequency–inverse
document
frequency
(TF-IDF)
count
vectorization,
ensured
high-quality
data
transformation.
random
forest
classifier
selected
its
ability
handle
high-dimensional
effectively
capture
linguistic
patterns
linked
ideation.
model’s
reliability
supported
by
precision–recall
AUC
score
0.93,
demonstrating
real-time
monitoring
intervention.
By
identifying
behavioral
triggers,
such
as
isolation
bullying,
this
framework
provides
scalable
efficient
solution
support,
contributing
significantly
prevention
strategies
worldwide.
BMJ Open,
Journal Year:
2025,
Volume and Issue:
15(2), P. e091923 - e091923
Published: Feb. 1, 2025
During
the
perinatal
period,
women
have
an
increased
risk
for
psychiatric
disorders,
which
are
highly
prevalent
in
this
context.
In
addition,
there
significant
delays
diagnosing
these
conditions,
worsening
their
prognosis
and
increasing
societal
burden.
Studies
describing
disorders
period
often
focus
on
specific
disorders;
only
postpartum
depression
and,
to
a
lesser
extent,
anxiety
studied.
There
also
very
few
evaluations
conducted
by
clinicians
based
semistructured
interview,
relying
diagnostic
criteria
of
international
nosography.
This
multicentric
prospective
study
will
recruit
140
adult
pregnant
randomly
selected
second
trimester
(T2)
ultrasound
consultations.
The
primary
outcome
is
prevalence
any
disorder
assessed
with
standardised
assessment,
Mini-International
Neuropsychiatric
Interview
(M.I.N.I.).
Within
10
days
after
T2
appointment,
we
conduct
M.I.N.I.,
collect
demographic
data,
evaluate
suicidal
behaviour
Columbia-Suicide
Severity
Rating
Scale,
describe
negative
life
events
from
past
year
using
Paykel
questionnaire
evaluation
social
deprivation
(Evaluation
Deprivation
Inequalities
Health
Healthcare
Centres
score).
Participants
complete
self-administered
questionnaires
that
screen
pathologies.
We
build
biological
sample
collection.
At
two
months
post
partum,
repeat
questionnaires,
adding
assessment
mother-child
bonding.
Patients
can
choose
between
in-person
or
telemedicine
visits
both
occasions.
All
participants
be
required
provide
written
informed
consent.
has
received
ethical
approval
French
National
Committee
('Comité
de
Protection
des
Personnes
Ouest
VI')
(approval
number:
23.03919.000236).
Results
disseminated
through
peer-reviewed
journal
publications
at
scientific
conferences
meetings.
NCT06297252.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 309 - 309
Published: Feb. 23, 2025
Background:
Depression
is
one
of
the
most
serious
and
common
health
problems
among
youth
population
responsible
for
initiation
many
diseases.
As
per
World
Health
Organization,
3.8%
suffers
from
mental
depression,
globally.
The
monoamine
oxidase-A
(MAO-A)
enzyme
degradation
neurotransmitters
leading
to
lower
levels
neurotransmitters.
Methods:
Chalcones
(C1-C15)
were
synthesized
by
reacting
substituted
acetophenone
with
various
benzaldehydes
in
a
basic
ethanolic
solvent
at
80
°C
under
microwave
irradiation
conditions.
To
compare
reaction
time
product
yield,
conventional
method
synthesis
chalcones
was
also
performed.
spectroscopically
characterized
screened
initially
inhibitory
activities
against
MAO-A
MAO-B.
best
active
compounds
undertaken
IC50
determination
followed
reversibility
inhibition
analysis
antioxidant
assay.
Moreover,
silico
molecular
docking
ADME
pharmacokinetic
investigations
accomplished.
Results:
Most
inhibited
MAO-A,
specifically,
C14
C6
exhibited
highest
values
7.91
±
0.08
μM
8.45
0.19
μM,
respectively.
Both
these
reversible
displaying
up
60%
recovery
enzymatic
activity
when
diluted
substrate
(Tyramine).
results
study
indicated
scores
−9.56
Kcal/mol
(C14)
−9.45
(C6)
π-π
stacking
interaction
crucial
amino
acid
Trp-397.
determined
cross
blood–brain
barrier
(BBB)
displayed
favorable
gastrointestinal
(GI)
absorption.
Further,
assay
demonstrated
that
possess
modest
free
radical
scavenging
potential.
Conclusions:
This
potential
morpholine-substituted
as
promising
pharmacophore
development
novel
antidepressant
lead
compounds.