Gout Urate and Crystal Deposition Disease, Год журнала: 2025, Номер 3(2), С. 7 - 7
Опубликована: Апрель 10, 2025
Monosodium urate, calcium pyrophosphate, and basic phosphate crystals are the most common types of found in joints. Each type crystal has been associated with onset different joint diseases. However, mechanisms identified for one often generalized to others; thus, overlooking specific distinct molecular cellular responses activated by each crystal. This review describes similarities differences main molecules underlying diseases three crystals. Specifically, current knowledge on properties formation, induction resolution inflammation, involved pain processing senescence, role mitochondria genomic instability elucidated. A more complete detailed study induced is necessary advance our understanding pathogenesis help identify innovative opportunities prevention treatment deposition disease.
Язык: Английский