Comparison of Pathophysiological Mechanisms Among Crystal-Induced Arthropathies DOI Open Access

M. Zangari,

Roberto Luisetto,

Roberto Pilot

et al.

Gout Urate and Crystal Deposition Disease, Journal Year: 2025, Volume and Issue: 3(2), P. 7 - 7

Published: April 10, 2025

Monosodium urate, calcium pyrophosphate, and basic phosphate crystals are the most common types of found in joints. Each type crystal has been associated with onset different joint diseases. However, mechanisms identified for one often generalized to others; thus, overlooking specific distinct molecular cellular responses activated by each crystal. This review describes similarities differences main molecules underlying diseases three crystals. Specifically, current knowledge on properties formation, induction resolution inflammation, involved pain processing senescence, role mitochondria genomic instability elucidated. A more complete detailed study induced is necessary advance our understanding pathogenesis help identify innovative opportunities prevention treatment deposition disease.

Language: Английский

Updates in Deposition Arthritis Other Than Gout DOI
Mark Kong, Huw Walters, James Teh

et al.

Seminars in Musculoskeletal Radiology, Journal Year: 2025, Volume and Issue: 29(02), P. 275 - 292

Published: March 31, 2025

Abstract This article focuses on updates in calcium pyrophosphate deposition disease (CPPD) and basic phosphate (BCPD), highlighting recent advances imaging the understanding of these conditions. It explores their clinical presentations, crystal formation mechanisms, diagnostic challenges. CPPD BCPD are often underrecognized causes arthritis, criteria presented.

Language: Английский

Citations

0
Comparison of Pathophysiological Mechanisms Among Crystal-Induced Arthropathies DOI Open Access

M. Zangari,

Roberto Luisetto,

Roberto Pilot

et al.

Gout Urate and Crystal Deposition Disease, Journal Year: 2025, Volume and Issue: 3(2), P. 7 - 7

Published: April 10, 2025

Monosodium urate, calcium pyrophosphate, and basic phosphate crystals are the most common types of found in joints. Each type crystal has been associated with onset different joint diseases. However, mechanisms identified for one often generalized to others; thus, overlooking specific distinct molecular cellular responses activated by each crystal. This review describes similarities differences main molecules underlying diseases three crystals. Specifically, current knowledge on properties formation, induction resolution inflammation, involved pain processing senescence, role mitochondria genomic instability elucidated. A more complete detailed study induced is necessary advance our understanding pathogenesis help identify innovative opportunities prevention treatment deposition disease.

Language: Английский

Citations

0