Medical Oncology, Год журнала: 2025, Номер 42(6)
Опубликована: Май 12, 2025
Язык: Английский
Theranostics, Год журнала: 2024, Номер 15(3), С. 993 - 1016
Опубликована: Дек. 2, 2024
Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.
Язык: Английский
Процитировано
34
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.
Язык: Английский
Процитировано
4
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 18, 2025
Abstract Researchers have found that mutations in the BRCA gene associated with breast cancer a 40–50% chance of being high risk for hereditary (BC). Therefore, detecting BRCA1 is crucial genetic analysis, early detection, and clinical treatment BC. Traditional detection methods include high-performance liquid chromatography (HPLC), single-strand conformation polymorphism assays (SSCP), PCR, real-time DNA sequencing. However, these are limited by cost, analysis time, complexity. it necessary to develop an ultrasensitive, fast, low-cost, simple method detection. In recent years, various BC biosensing strategies been investigated, including optical, electrical, electrochemical, mechanical biosensing. particular, sensitivity short times electrochemical biosensors make them suitable recognizing biomarkers. Additionally, can be increased incorporating nanomaterials. this regard, main focus present study introduction common diagnosing BRCA-1/2 genes. addition introducing as efficient tool, also discusses latest most significant developed gene.
Язык: Английский
Процитировано
2
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Окт. 8, 2022
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to COVID-19 and has become a pandemic worldwide with mortality of millions. Nanotechnology can be used deliver antiviral medicines or other types viral reproduction-inhibiting medications. At various steps infection, nanotechnology could suggest practical solutions for usage in the fight against infection. Nanotechnology-based approaches help SARS-CoV-2 Nanoparticles play an essential role progressing treatment vaccine production efficacy safety. Nanocarriers have increased speed development efficiency vaccines. As result, investigation into nanoparticles as nano-delivery systems nanotherapeutics new effective methods are inhibiting In this article, we compare attributes several evaluate their capability create novel vaccines different diseases, especially disease. Graphical
Язык: Английский
Процитировано
62
Molecular Biology Reports, Год журнала: 2023, Номер 50(4), С. 3023 - 3033
Опубликована: Янв. 20, 2023
Язык: Английский
Процитировано
37
Medical Oncology, Год журнала: 2023, Номер 40(6)
Опубликована: Май 8, 2023
Язык: Английский
Процитировано
30
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 80, С. 104167 - 104167
Опубликована: Янв. 11, 2023
Язык: Английский
Процитировано
26
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Март 11, 2024
Apoptosis is a programmed cell death comprising two signaling cascades including the intrinsic and extrinsic pathways. This process has been shown to be involved in therapy response of different cancer types, making it an effective target for treating cancer. Cancer considered challenging issue global health. cells possess six biological characteristics during their developmental known as hallmarks. Hallmarks include continuous growth signals, unlimited proliferation, resistance proliferation inhibitors, apoptosis escaping, active angiogenesis, metastasis. Sesquiterpene lactones are one large diverse groups planet-derived phytochemicals that can used sources variety drugs. Some sesquiterpene many activities such anti-inflammatory, anti-viral, anti-microbial, anti-malarial, anticancer, anti-diabetic, analgesic. review article briefly overviews pathways interactions between modulators both Also, present summarizes potential effects on lines animal models. The main purpose give clear picture current knowledge about pro-apoptotic various cancers provide future direction therapeutics.
Язык: Английский
Процитировано
11
Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Июнь 27, 2023
Introduction: In recent years, various nanoparticles (NPs) have been discovered and synthesized for the targeted therapy of cancer cells. Targeted delivery increases local concentration therapeutics minimizes side effects. Therefore, NPs-mediated drug systems become a promising approach treatment cancers. As result, in current study, we aimed to design silibinin-loaded magnetic niosomes (MNNPs) investigate their cytotoxicity property colorectal cell treatment. Methods: MNPs ferrofluids were prepared encapsulated into (NIOs) by thin film hydration method. Afterward, morphology, size, chemical structure MNNPs evaluated using TEM, DLS, FT-IR techniques, respectively. Results Discussion: The distribution number was obtained at about 50 nm 70 with surface charge -19.0 mV TEM DLS analysis, Silibinin loading efficiency NIOs 90%, release pattern showed controlled maximum amount 49% 70%, within 4 h pH = 7.4 5.8, To effect, HT-29 cells treated drugs 24 48 MTT as well flow cytometry assays. Obtained results demonstrated promoted (5-fold decrease viability) compared pure silibinin (3-fold while had no significant cytotoxic effect on HEK-293 (normal line) cells, cellular uptake level line enhanced control group. conclusion, complex can be considered an efficient
Язык: Английский
Процитировано
22