Asian Pacific Journal of Cancer Prevention,
Год журнала:
2024,
Номер
25(7), С. 2539 - 2550
Опубликована: Июль 1, 2024
Colorectal
cancer
is
a
significant
global
health
concern
with
high
mortality
rates.
Silibinin
compound
derived
from
milk
thistle
anticancer
properties
and
may
be
potential
treatment
option
for
colorectal
cancer.
Its
poor
solubility
limits
its
clinical
application,
but
various
strategies,
such
as
nanoparticle
encapsulation,
have
shown
promise.
In
this
study,
PEGylated
niosomal
drug
delivery
system
was
used
to
enhance
the
of
silibinin,
anti-proliferative
effects
were
evaluated
against
human
cell
lines.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 223 - 223
Опубликована: Фев. 4, 2024
Niosomes
are
vesicular
nanocarriers,
biodegradable,
relatively
non-toxic,
stable,
and
inexpensive,
that
provide
an
alternative
for
lipid-solid
carriers
(e.g.,
liposomes).
may
resolve
issues
related
to
the
instability,
fast
degradation,
bioavailability,
insolubility
of
different
drugs
or
natural
compounds.
can
be
very
efficient
potential
systems
specific
delivery
anticancer,
antioxidant,
anti-inflammatory,
antimicrobial,
antibacterial
molecules.
This
review
aims
present
overview
their
composition,
most
common
formulation
techniques,
as
well
recent
utilizations
in
cancer
therapy.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 27, 2023
Introduction:
In
recent
years,
various
nanoparticles
(NPs)
have
been
discovered
and
synthesized
for
the
targeted
therapy
of
cancer
cells.
Targeted
delivery
increases
local
concentration
therapeutics
minimizes
side
effects.
Therefore,
NPs-mediated
drug
systems
become
a
promising
approach
treatment
cancers.
As
result,
in
current
study,
we
aimed
to
design
silibinin-loaded
magnetic
niosomes
(MNNPs)
investigate
their
cytotoxicity
property
colorectal
cell
treatment.
Methods:
MNPs
ferrofluids
were
prepared
encapsulated
into
(NIOs)
by
thin
film
hydration
method.
Afterward,
morphology,
size,
chemical
structure
MNNPs
evaluated
using
TEM,
DLS,
FT-IR
techniques,
respectively.
Results
Discussion:
The
distribution
number
was
obtained
at
about
50
nm
70
with
surface
charge
-19.0
mV
TEM
DLS
analysis,
Silibinin
loading
efficiency
NIOs
90%,
release
pattern
showed
controlled
maximum
amount
49%
70%,
within
4
h
pH
=
7.4
5.8,
To
effect,
HT-29
cells
treated
drugs
24
48
MTT
as
well
flow
cytometry
assays.
Obtained
results
demonstrated
promoted
(5-fold
decrease
viability)
compared
pure
silibinin
(3-fold
while
had
no
significant
cytotoxic
effect
on
HEK-293
(normal
line)
cells,
cellular
uptake
level
line
enhanced
control
group.
conclusion,
complex
can
be
considered
an
efficient
Indian Journal of Microbiology Research,
Год журнала:
2023,
Номер
10(1), С. 1 - 10
Опубликована: Май 1, 2023
Probiotics
are
beneficial
microorganisms
that
have
shown
to
possess
numerous
health
benefits.
Recently,
there
has
been
budding
interests
in
the
utilization
of
probiotics
as
a
prospective
weapon
for
cancer
deterrence
and
management.
The
antioncogenic
attributes
were
provided
through
various
mechanisms
such
immune
modulation,
production
anticancer
compounds,
regulation
intestinal
microbiota.
current
study
shed
light
on
probiotic
strains
explored
their
mechanisms.
However,
use
prevention
treatment
also
poses
several
challenges,
including
identification
specific
with
most
potent
effects,
optimal
dosage
duration
treatment,
hazards
allied
implementation
live
microorganisms.
Additionally,
heterogeneity
types
patients'
microbiomes
further
complicate
selection
clinical
applications.
Hence,
future
should
concentrate
development
alternative
approaches
microbial-derived
components,
genetically
modified
probiotics,
synthetic
biology
overcome
these
challenges
enhance
potential
probiotics.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 17, 2023
Background
Despite
current
therapies,
lung
cancer
remains
a
global
issue
and
requires
the
creation
of
novel
treatment
methods.
Recent
research
has
shown
that
biguanides
such
as
metformin
(MET)
silibinin
(SIL)
have
potential
anticancer
effect.
As
consequence,
effectiveness
MET
SIL
in
combination
against
cells
was
investigated
this
study
to
develop
an
effective
method.
Methods
Niosomal
nanoparticles
were
synthesized
via
thin-film
hydration
method,
field
emission
scanning
electron
microscopy
(FE-SEM),
Fourier
transform
infrared
(FTIR),
atomic
force
(AFM),
dynamic
light
scattering
(DLS)
techniques
used
evaluate
their
physico-chemical
characteristics.
The
cytotoxic
effects
free
drug-loaded
(NPs),
well
combination,
on
A549
assessed
using
MTT
assay.
An
apoptosis
test
while
under
influence
medication
identify
molecular
mechanisms
behind
programmed
cell
death.
With
use
cycle
test,
it
determined
whether
pharmaceutical
caused
stop
progressing.
Additionally,
qRT-PCR
technique
levels
hTERT,
BAX,
BCL-2
gene
expression
after
48-h
treatment.
Results
In
cytotoxicity
assay,
growth
inhibited
by
both
SIL.
Compared
individual
dramatically
synergistically
decreased
IC50
values
cells.
Furthermore,
produced
lower
better
anti-proliferative
effect
Real-time
PCR
results
showed
hTERT
significantly
reduced
lines
treated
with
compared
single
treatments
(p<
0.001).
Conclusion
It
is
anticipated
nano-niosomal-formed
would
improve
outcomes
therapeutic
efficiency
Asian Pacific Journal of Cancer Prevention,
Год журнала:
2023,
Номер
24(5), С. 1817 - 1825
Опубликована: Май 1, 2023
In
recent
years,
molecular
targeted
therapy
has
attracted
more
attention
from
researchers
due
to
its
high
efficiency
and
fewer
side
effects.
Researchers
are
attempting
find
specific
ways
treat
diseases.
It
been
found
that
there
different
targets
for
the
treatment
of
diseases
such
as
cancer,
obesity,
metabolic
syndrome.
is
important
a
potential
target
in
order
lessen
effects
current
treatments.
G
Protein-coupled
receptors
(GPCRs)
large
family
transmembrane
proteins
expressed
many
organs,
leading
activation
internal
signal
transduction
cascades
through
binding
ligands,
including
neurotransmitters,
peptides,
lipids.
Due
critical
role
GPCRs
cells,
it
could
be
target.
protein-coupled
receptor
75
(GPR75)
novel
member
GPCR
an
diseases,
Until
now,
three
ligands
have
detected
GPR75,
20-HETE,
CCL5,
RANTES.
Recent
studies
suggest
triggers
signaling
pathways
PI3K/Akt
RAS/MAPK,
aggressive
phenotype
prostate
cancer
cells.
Additionally,
RAS/MAPK
activate
NF-κB,
which
significant
various
development
proliferation,
migration,
apoptosis.
The
findings
indicate
inhibiting
GPR75
humans
leads
increase
insulin
sensitivity
glucose
tolerance,
well
reduction
body
fat
storage.
According
these
discoveries,
drug
syndrome,
cancer.
this
review,
we
aimed
discuss
therapeutic
impact
obesity
underscore
possible
pathways.
