Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells

Pharmacological Reports, Год журнала: 2023, Номер 75(2), С. 442 - 455

Опубликована: Март 1, 2023

Язык: Английский

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The development of nanocarriers for natural products

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(3)

Опубликована: Май 1, 2024

Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems

Язык: Английский

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Research progress on the signaling pathway mechanism of terpenoids against breast cancer

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Март 31, 2025

Язык: Английский

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Potential Anti-Proliferative Effect of Nano-formulated Curcumin Through Modulating Micro RNA- 132, Cyclin D1, and hTERT Genes Expression in Breast Cancer Cell Lines

Journal of Cluster Science, Год журнала: 2023, Номер 34(5), С. 2537 - 2546

Опубликована: Фев. 8, 2023

Язык: Английский

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Fabricating niosomal-PEG nanoparticles co-loaded with metformin and silibinin for effective treatment of human lung cancer cells

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Авг. 17, 2023

Background Despite current therapies, lung cancer remains a global issue and requires the creation of novel treatment methods. Recent research has shown that biguanides such as metformin (MET) silibinin (SIL) have potential anticancer effect. As consequence, effectiveness MET SIL in combination against cells was investigated this study to develop an effective method. Methods Niosomal nanoparticles were synthesized via thin-film hydration method, field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FTIR), atomic force (AFM), dynamic light scattering (DLS) techniques used evaluate their physico-chemical characteristics. The cytotoxic effects free drug-loaded (NPs), well combination, on A549 assessed using MTT assay. An apoptosis test while under influence medication identify molecular mechanisms behind programmed cell death. With use cycle test, it determined whether pharmaceutical caused stop progressing. Additionally, qRT-PCR technique levels hTERT, BAX, BCL-2 gene expression after 48-h treatment. Results In cytotoxicity assay, growth inhibited by both SIL. Compared individual dramatically synergistically decreased IC50 values cells. Furthermore, produced lower better anti-proliferative effect Real-time PCR results showed hTERT significantly reduced lines treated with compared single treatments (p< 0.001). Conclusion It is anticipated nano-niosomal-formed would improve outcomes therapeutic efficiency

Язык: Английский

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Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review

Drug Delivery and Translational Research, Год журнала: 2023, Номер 13(11), С. 2739 - 2766

Опубликована: Июнь 1, 2023

Язык: Английский

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Recent advances in molecular targeted therapy of lung cancer: Possible application in translation medicine.

PubMed, Год журнала: 2024, Номер 27(2), С. 122 - 133

Опубликована: Янв. 1, 2024

Lung cancer is one of the leading causes death among all deaths. This classified into two different histological subtypes: non-small cell lung (NSCLC), which most common subtype, and small (SCLC), aggressive subtype. Understanding molecular characteristics has expanded our knowledge cellular origins pathways affected by each these subtypes contributed to development new therapies. Traditional treatments for include surgery, chemotherapy, radiotherapy. Advances in understanding nature specificity have led immunotherapy, newest specialized treatment cancer. Each advantages disadvantages side effects. Today, combination therapy reduces effects increases speed recovery. Despite significant progress that been made last decade, further research drugs therapies needed extend clinical benefits improve outcomes In this review article, we discussed their combinations from advanced newest.

Язык: Английский

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Zinc Oxide Nanoparticles and Cancer Chemotherapy: Helpful Tools for Enhancing Chemo-sensitivity and Reducing Side Effects?

Biological Trace Element Research, Год журнала: 2023, Номер 202(5), С. 1878 - 1900

Опубликована: Авг. 28, 2023

Язык: Английский

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Phytometabolites as modulators of breast cancer: a comprehensive review of mechanistic insights

Medical Oncology, Год журнала: 2024, Номер 41(2)

Опубликована: Янв. 3, 2024

Язык: Английский

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Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells

DARU Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 32(1), С. 133 - 144

Опубликована: Янв. 3, 2024

Язык: Английский

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