Fabrication of α-lactalbumin-coated chamomile nano-emulsion for their synergistic anticancer and anti-inflammatory applications DOI
Ali G. Alkhathami,

Mahmoud Ashry,

Omkulthom Al Kamaly

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 12, 2025

Language: Английский

Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells DOI

Rasoul Shahbazi,

Davoud Jafari-Gharabaghlou, Zohreh Mirjafary

et al.

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(2), P. 442 - 455

Published: March 1, 2023

Language: Английский

Citations

21
The development of nanocarriers for natural products DOI
Liying Huang, Shicui Luo, Sen Tong

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems

Language: Английский

Citations

6
Potential Anti-Proliferative Effect of Nano-formulated Curcumin Through Modulating Micro RNA- 132, Cyclin D1, and hTERT Genes Expression in Breast Cancer Cell Lines DOI

Somayeh Amirsaadat,

Davoud Jafari-Gharabaghlou, Mehdi Dadashpour

et al.

Journal of Cluster Science, Journal Year: 2023, Volume and Issue: 34(5), P. 2537 - 2546

Published: Feb. 8, 2023

Language: Английский

Citations

15
Fabricating niosomal-PEG nanoparticles co-loaded with metformin and silibinin for effective treatment of human lung cancer cells DOI Creative Commons

Elnaz Salmani-Javan,

Davoud Jafari-Gharabaghlou,

Esat Bonabi

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Aug. 17, 2023

Background Despite current therapies, lung cancer remains a global issue and requires the creation of novel treatment methods. Recent research has shown that biguanides such as metformin (MET) silibinin (SIL) have potential anticancer effect. As consequence, effectiveness MET SIL in combination against cells was investigated this study to develop an effective method. Methods Niosomal nanoparticles were synthesized via thin-film hydration method, field emission scanning electron microscopy (FE-SEM), Fourier transform infrared (FTIR), atomic force (AFM), dynamic light scattering (DLS) techniques used evaluate their physico-chemical characteristics. The cytotoxic effects free drug-loaded (NPs), well combination, on A549 assessed using MTT assay. An apoptosis test while under influence medication identify molecular mechanisms behind programmed cell death. With use cycle test, it determined whether pharmaceutical caused stop progressing. Additionally, qRT-PCR technique levels hTERT, BAX, BCL-2 gene expression after 48-h treatment. Results In cytotoxicity assay, growth inhibited by both SIL. Compared individual dramatically synergistically decreased IC50 values cells. Furthermore, produced lower better anti-proliferative effect Real-time PCR results showed hTERT significantly reduced lines treated with compared single treatments (p< 0.001). Conclusion It is anticipated nano-niosomal-formed would improve outcomes therapeutic efficiency

Language: Английский

Citations

14
Recent advances in molecular targeted therapy of lung cancer: Possible application in translation medicine. DOI

Elnaz Salmani-Javan,

Mahdi Farhoudi Sefidan Jadid,

Nosratollah Zarghami

et al.

PubMed, Journal Year: 2024, Volume and Issue: 27(2), P. 122 - 133

Published: Jan. 1, 2024

Lung cancer is one of the leading causes death among all deaths. This classified into two different histological subtypes: non-small cell lung (NSCLC), which most common subtype, and small (SCLC), aggressive subtype. Understanding molecular characteristics has expanded our knowledge cellular origins pathways affected by each these subtypes contributed to development new therapies. Traditional treatments for include surgery, chemotherapy, radiotherapy. Advances in understanding nature specificity have led immunotherapy, newest specialized treatment cancer. Each advantages disadvantages side effects. Today, combination therapy reduces effects increases speed recovery. Despite significant progress that been made last decade, further research drugs therapies needed extend clinical benefits improve outcomes In this review article, we discussed their combinations from advanced newest.

Language: Английский

Citations

5
Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review DOI
Priya Gupta, Yub Raj Neupane, Mohd. Aqil

et al.

Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 13(11), P. 2739 - 2766

Published: June 1, 2023

Language: Английский

Citations

11
Phytometabolites as modulators of breast cancer: a comprehensive review of mechanistic insights DOI
Priyanka Sharma, Khushi Gupta,

Sumit Kumar Khandai

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 3, 2024

Language: Английский

Citations

4
Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells DOI

Salah Jaafar Abdulkareem,

Davoud Jafari-Gharabaghlou,

Mahdi Farhoudi-Sefidan-Jadid

et al.

DARU Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 32(1), P. 133 - 144

Published: Jan. 3, 2024

Language: Английский

Citations

4
Effect of different nanoparticles on physicochemical and biological properties of emulsion templated poly (ɛ-caprolactone) scaffolds DOI
Anilkumar Yadav, Meenal Agrawal,

Sonam Takkar

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135597 - 135597

Published: Oct. 1, 2024

Language: Английский

Citations

4
EGF-induced P-gp expression in tumor vasculature contributes to therapeutic resistance to Doxorubicin-PEG-liposomes in mice bearing Doxorubicin-resistant B16-BL6 tumors DOI
Masato Maruyama,

Tomoki Ueda,

Yusuke Ienaka

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106690 - 106690

Published: Feb. 1, 2025

Language: Английский

Citations

0