Endophytic fungi-bioinspired nanoparticles potential to control infectious disease DOI
Sohail Khan, Fazlurrahman Khan, Ashwani Mathur

и другие.

Critical Reviews in Microbiology, Год журнала: 2025, Номер unknown, С. 1 - 23

Опубликована: Май 5, 2025

The growing demand for nanomedicine and its potentially diverse biological function required the investigation of raw materials fabricating nanomaterial. Current developments have emphasized implementation green chemistry to develop metal-oxide metal nanoparticles. Endophytic fungi emerged as a potential reservoir bioactive compounds exemplified by unique structures influential antibacterial properties. Over past decade, substantial progress has been achieved in uncovering profiling these valuable compounds. These endophytic fungi-derived chemicals applications various Nanoparticle synthesis from derived fungi, be it whole extracts or pure components, owing their accessibility, cost-effectiveness fabrication, material-tissue compatibility, modest cytotoxicity toward higher organism cells. Nanoparticles utilized treat diseases, including those caused bacterial, viral, fungal pathogens. present review provides comprehensive discussion mechanistic insight into application fungi-bioinspired nanoparticles therapeutic agents control microbial infection. underlying action mechanism involved antimicrobial also discussed. highlights attributes that may significantly benefit future researchers

Язык: Английский

Unveiling biological activities of biosynthesized starch/silver-selenium nanocomposite using Cladosporium cladosporioides CBS 174.62 DOI Creative Commons
Fathy M. Elkady, Amr H. Hashem, Salem S. Salem

и другие.

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Март 8, 2024

Abstract Background and objectives Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. Methodology St/Ag-Se NC was using Cladosporium cladosporioides CBS 174.62 ( C. ) strain. shape average particle size investigated scanning electron microscope (SEM) high-resolution transmission (HR-TEM), respectively. On other hand, on two cancer cell lines red blood (RBCs) evaluated its hydrogen peroxide (H 2 O scavenging Moreover, effects microbial species in both planktonic biofilm growth forms examined. Results successfully oval spherical mean diameter 67.87 nm as confirmed by HR-TEM analysis. showed promising anticancer activity toward human colorectal carcinoma (HCT-116) breast (MCF-7) where IC 50 21.37 19.98 µg/ml, Similarly, little RBCs observed low concentration. As well, highest H (42.84%) recorded at concentration mg/ml. Additionally, Staphylococcus epidermidis S. ATCC 12,228 Candida albicans 10,231 highly affected bacterial fungal strains minimum inhibitory concentrations (MICs) 18.75 noticeable dependent. A high suppression percentage, 87.5% 68.05%, aureus when exposed 1 mg/ml 0.5 mg/ml, Conclusion excellent antioxidant activity, haemocompatibility, anti-proliferative concentrations. Also, it exhibited antibiofilm activities.

Язык: Английский

Процитировано

17

Biogenic Nanomaterials: Synthesis, Characterization, and Applications DOI
Salem S. Salem, Alsayed E. Mekky

Environmental science and engineering, Год журнала: 2024, Номер unknown, С. 13 - 43

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

12

Hindering the biofilm of microbial pathogens and cancer cell lines development using silver nanoparticles synthesized by epidermal mucus proteins from Clarias gariepinus DOI Creative Commons
Ahmed N. Alabssawy, Mohammed Abu‐Elghait, Ahmad M. Azab

и другие.

BMC Biotechnology, Год журнала: 2024, Номер 24(1)

Опубликована: Май 4, 2024

Abstract Scientists know very little about the mechanisms underlying fish skin mucus, despite fact that it is a component of immune system. Fish mucus an important defence against invasive infections. Recently, and its are gaining interest among immunologists. Characterization was done on obtained silver nanoparticles Ag combined with Clarias gariepinus catfish epidermal proteins (EMP-Ag-NPs) through UV–vis, FTIR, XRD, TEM, SEM. Ag-NPs ranged in size from 4 to 20 nm, spherical form angles were 38.10°, 44.20°, 64.40°, 77.20°, Where wavelength change after formation EMP-Ag-NPs as indicate dark brown, broad band recorded at 391 nm. Additionally, antimicrobial, antibiofilm anticancer activities assessed. The present results demonstrate high activity unicellular fungi C. albicans , followed by E. faecalis . Antibiofilm showed strong both S. aureus P. aeruginosa pathogens dose-dependent manner, without affecting planktonic cell growth. Also, cytotoxicity effect investigated normal cells (Vero), breast cancer (Mcf7) hepatic carcinoma (HepG2) lines concentrations (200–6.25 µg/mL) current highly 100, 5 25 µg/mL exhibited rounding, shrinkage, deformation granulation Mcf7 HepG2 IC50 19.34 31.16 respectively while Vero appeared rounded concentration 50 shape 25, 12.5 6.25 µg/ml 35.85 µg/mL. This study evidence potential efficacy biologically generated substitute medicinal agent harmful microorganisms. Furthermore, highlights their inhibitory lines.

Язык: Английский

Процитировано

11

An Eco-Friendly Synthesis Approach for Enhanced Photocatalytic and Antibacterial Properties of Copper Oxide Nanoparticles Using Coelastrella terrestris Algal Extract DOI Creative Commons

Manisha Khandelwal,

Sunita Choudhary,

Harish Mangesh

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4137 - 4162

Опубликована: Май 1, 2024

Background: In the current scenario, synthesis of nanoparticles (NPs) using environmentally benign methods has gained significant attention due to their facile processes, cost-effectiveness, and eco-friendly nature. Methods: present study, copper oxide (CuO NPs) were synthesized aqueous extract Coelastrella terrestris algae as a reducing, stabilizing, capping agent. The CuO NPs characterized by X-ray diffraction (XRD), UV-visible spectroscopy (UV-Vis), Fourier transform infrared (FTIR), dynamic light scattering (DLS), field emission scanning electron microscopy (FE-SEM) coupled with energy-dispersive (EDS). Results: XRD investigation revealed that biosynthesized nanocrystalline high-phase purity size in range 4.26 nm 28.51 nm. FTIR spectra confirmed existence secondary metabolites on surface NPs, characteristic Cu–O vibrations being identified around 600 cm − 1 , 496 440 . FE-SEM images predicted enhancement algal amount converted flattened rice-like structures into flower petal-like structures. Furthermore, degradation ability was investigated against Amido black 10B (AB10B) dye. results displayed optimal efficacy AB10B dye 94.19%, obtained at 6 pH, 50 ppm concentration dye, 0.05 g dosage 90 min pseudo-first-order rate constant 0.0296 CuO-1 through exhibited notable antibacterial S. aureus zone inhibition (ZOI) 22 mm P. aeruginosa ZOI 17 mm. Conclusion: Based findings this it can be concluded utilizing for presents promising solution addressing environmental contamination. Keywords: green synthesis, photocatalysis, activity, wastewater treatment

Язык: Английский

Процитировано

11

Biosynthesis and characterization of selenium and silver nanoparticles using Trichoderma viride filtrate and their impact on Culex pipiens DOI Creative Commons

Heba Abd-elKhalek,

Ali A. Badawy, Abdulaziz A. Al–Askar

и другие.

Green Processing and Synthesis, Год журнала: 2024, Номер 13(1)

Опубликована: Янв. 1, 2024

Abstract Some of the significant globally prevalent vector-borne illnesses are caused by Culex pipiens . Synthetic pesticides have been widely utilized to eradicate C. , which has led a number health risks for people, insect resistance, and environmental contamination. Alternative strategies therefore vitally needed. In current investigation, Trichoderma viride fungal culture filtrate was used create selenium silver nanoparticles (SeNPs AgNPs, respectively) test them on larvae in their fourth instar stage. The death rate increased significantly when SeNP AgNP concentrations increased, according results. SeNPs AgNPs affected developmental detoxification enzymes at 24 h after being treated with sublethal concentration tested NPs. As result insecticidal effect larvae, considered effective promising larvicidal agents.

Язык: Английский

Процитировано

11

A comprehensive review on antibacterial analysis of natural extract-based metal and metal oxide nanoparticles DOI

M. Shandhiya,

B. Janarthanan,

S. Sharmila

и другие.

Archives of Microbiology, Год журнала: 2024, Номер 206(1)

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

10

Spirulina-mediated biosynthesis of gold nanoparticles: an interdisciplinary study on antimicrobial, antioxidant, and anticancer properties DOI
Mohammad Aamir, Said Hassan, Amir Hamza Khan

и другие.

Journal of Sol-Gel Science and Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

2

Optimization Growth Conditions of Fusarium pseudonygamai for Myco-Synthesized Gold and Silver Nanoparticles Using Response Surface Methodology DOI
Salem S. Salem, Mohamed K. Y. Soliman, Mohamed Salah Azab

и другие.

BioNanoScience, Год журнала: 2024, Номер 14(5), С. 5420 - 5435

Опубликована: Март 9, 2024

Язык: Английский

Процитировано

9

Inorganic nanoparticle-cored dendrimers for biomedical applications: A review DOI Creative Commons
Sepand Tehrani Fateh, Amir Hossein Aghaii, Zahra Aminzade

и другие.

Heliyon, Год журнала: 2024, Номер 10(9), С. e29726 - e29726

Опубликована: Апрель 16, 2024

Hybrid nanostructures exhibit a synergistic combination of features derived from their individual components, showcasing novel characteristics resulting distinctive structure and chemical/physical properties. Surface modifiers play pivotal role in shaping INPs' primary attributes, influencing physicochemical properties, stability, functional applications. Among these modifiers, dendrimers have gained attention as highly effective multifunctional agents for INPs, owing to unique structural qualities, dendritic effects, Dendrimers can be seamlessly integrated with diverse inorganic nanostructures, including metal NPs, carbon silica QDs. Two viable approaches achieving this integration involve either growing or grafting dendrimers, nanostructure-cored dendrimers. The initial step involves functionalizing the nanostructures' surface, followed by generation through stepwise growth attachment pre-synthesized dendrimer branches. This hybridization imparts superior qualities structure, biocompatibility, solubility, high cargo loading capacity, substantial functionalization potential. Combining properties those nanostructure cores creates system suitable applications such theranostics, bio-sensing, component isolation, chemotherapy, cargo-carrying review summarizes recent developments, specific focus on last five years, within realm It delves into INPs explores potential INP-cored biomedical

Язык: Английский

Процитировано

8

A novel functionalized CuTi hybrid nanocomposites: facile one-pot mycosynthesis, characterization, antimicrobial, antibiofilm, antifouling and wastewater disinfection performance DOI Creative Commons

Asmaa G. Almahdy,

Ahmed El-Sayed, Marwa Eltarahony

и другие.

Microbial Cell Factories, Год журнала: 2024, Номер 23(1)

Опубликована: Май 23, 2024

Abstract Background The continuous progress in nanotechnology is rapid and extensive with overwhelming futuristic aspects. Through modernizing inventive synthesis protocols, a paradigm leapfrogging novelties findings are channeled toward fostering human health sustaining the surrounding environment. Owing to overpricing jeopardy of physicochemical synthesizing approaches, quest for ecologically adequate schemes incontestable. By developing environmentally friendly strategies, mycosynthesis nanocomposites has been alluring. Results Herein, novel architecture binary CuO TiO 2 form was fabricated using bionanofactory Candida sp. , first time. For accentuating structural properties CuTi (CuTiNCs), various characterization techniques were employed. UV-Vis spectroscopy detected SPR at 350 nm, XRD ascertained crystalline nature hybrid system. However, absorption peaks 8, 4.5, 0.5 keV confirmed presence Cu, Ti oxygen, respectively, an undefined assemblage polygonal-spheres 15–75 nm aggregated fungal matrix biomolecules as revealed by EDX, SEM TEM. FTIR, ζ-potential TGA reflected long-term stability (− 27.7 mV) self-functionalized CuTiNCs. Interestingly, considerable significant biocide performance 50 µg/mL CuTiNCs against some plant pathogens, compared monometallic counterparts. Further, (200 µg/mL) ceased significantly development Staphylococcus aureus Pseudomonas aeruginosa albicans biofilms 80.3 ± 1.4, 68.7 3.0 55.7 3.0%, respectively. Whereas, 64.63 3.5 89.82 4.3% antimicrofouling potentiality recorded 100 200 µg/ml CuTiNCs, respectively; highlighting their destructive effect marine microfoulers cells decaying extracellular polymeric skeleton visualized SEM. Moreover, (100 µg/ml) exerted outstanding disinfection potency within h reducing microbial load (i.e., total plate count, mold & yeast, coliforms faecal Streptococcus ) domestic agricultural effluents reached >50%. Conclusion synergistic efficiency provided CuNPs TiNPs mycofunctionalized boosted its recruitment antiphytopathogenic, antibiofilm, disinfectant agent realms.

Язык: Английский

Процитировано

7