Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients?

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Март 29, 2022

OPINION article Front. Endocrinol., 29 March 2022Sec. Translational Endocrinology https://doi.org/10.3389/fendo.2022.843152

Язык: Английский

---

Metal-induced oxidative stress and human plasma protein oxidation after SARS-CoV-2 infection

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Фев. 10, 2023

Pathogenesis of COVID-19 by SARS-CoV-2 resulted in a global pandemic and public health emergency 2020. Viral infection can induce oxidative stress through reactive oxygen species (ROS). Inflammation environmental are major sources after infection. Micronutrients such as iron, copper, zinc, manganese play various roles human tissues their imbalance blood impact immune responses against pathogens including SARS CoV-2. We hypothesized that alteration free metal ions during metal-catalyzed oxidation plays critical role towards pathogenesis analyzed convalescent hospitalized patient plasma using orthogonal analytical techniques to determine redox active concentrations, overall protein oxidation, modifications, levels via proteomics understand the consequences metal-induced proteins. Metal analysis ICP-MS showed significantly greater concentrations copper compared healthy controls. demonstrate total carbonylation, other deamidation proteins Proteomics hemoglobulin were elevated plasma. Molecular modeling concurred with potential interactions between iron binding CoV-2 surface Overall, increased metals indicate stress-induced may be consequence host cell resulting altered cellular homeostasis.

Язык: Английский

---

Preparation and activity study of Ruoqiang jujube polysaccharide copper chelate

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 11, 2024

Background: Polysaccharide metal chelate exhibit both immunoregulatory activity and element supplementation effects. Methods: In this study, Ruoqiang jujube polysaccharide copper (RJP-Cu) was prepared the preparation conditions were optimized using response surface method. Subsequently, RJP-Cu administered to lambs evaluate its impact on growth performance, ion (Cu 2+ ) supplementation, immune enhancement, intestinal flora evaluated. Results: The results indicated that optimal chelation included a sodium citrate content of 0.5 g, reaction temperature 50°C, solution pH 8.0, resulting in Cu concentration 583°mg/kg RJP-Cu. Scanning electron microscopy (SEM) revealed significant structural changes RJP before after chelation. displaying characteristic peaks polysaccharides chelates. Blood routine indexes showed no differences among RJP-Cu-High dose group (RJP-Cu-H), RJP-Cu-Medium (RJP-Cu-M), RJP-Cu-low (RJP-Cu-L) control ( p > 0.05). However, compared with group, RJP-Cu-H, M, L groups significantly enhanced lamb production performance < Furthermore, increased serum concentration, total antioxidant capacity (T-AOC), catalase (CAT), superoxide dismutase (T-SOD) contents RJP-Cu-H exhibited increases IgA IgG antibodies, as well secretion cytokines IL-2, IL-4, TNF-α (p species abundance microbiota, quantity beneficial bacteria, decrease harmful bacteria. led promotion synthesis various Short Chain Fatty Acids (SCFAs), improvements atrazine degradation clavulanic acid biosynthesis lambs, while reducing cell apoptosis lipopolysaccharide biosynthesis. Conclusion: Thus, these findings demonstrate RJP-Cu, chelate, could effectively promote increase content, potentially induce positive immunomodulatory effects by regulating enzymes, cytokines, flora, related metabolic pathways.

Язык: Английский

---

The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients Infected with SARS-CoV-2 and Potentially Non-Infected Participants: A Cross-Sectional Study

Nutrients, Год журнала: 2021, Номер 13(10), С. 3368 - 3368

Опубликована: Сен. 25, 2021

Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations 25-hydroxyvitamin (25(OH)D) in COVID-19 outpatients with those potentially non-infected participants. The association clinical symptoms vitamin status was also examined. A checklist laboratory examination were applied to collect data a cross-sectional conducted on 53 infected Serum concentration 25(OH)D not significantly lower patients moderate illness (19 ± 12 ng/mL) than asymptomatic or mild (29 18 ng/mL), trend noted for (p = 0.054). Infected (101 µg/dL) showed participants (114 13 0.01). Patients normal (odds ratio (OR), 0.19; p ≤ 0.001) insufficient (OR, 0.3; 0.007) at second seventh days disease had decreased OR general deficiency. revealed importance measurement predict progression pulmonary that

Язык: Английский

---

The Associations of Iron Related Biomarkers with Risk, Clinical Severity and Mortality in SARS-CoV-2 Patients: A Meta-Analysis

Nutrients, Год журнала: 2022, Номер 14(16), С. 3406 - 3406

Опубликована: Авг. 19, 2022

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), is spreading rapidly around the world and has led to millions of infections deaths. Growing evidence indicates that iron metabolism associated with COVID-19 progression, iron-related biomarkers have great potential for detecting these diseases. However, results previous studies are conflicting, there not consistent numerical magnitude relationship between those COVID-19. Thereby, we aimed integrate current further explore their relationships through a meta-analysis. We searched peer-reviewed literature in PubMed, Scopus Web Science up 31 May 2022. A random effects model was used pooling standard mean difference (SMD) calculation corresponding 95% confidence interval (CI). I2 evaluate heterogeneity among studies. total 72 eligible articles were included It found ferritin levels patients increased severity disease, whereas serum hemoglobin showed opposite trends. In addition, non-survivors had higher (SMD (95%CI): 1.121 (0.854, 1.388); Z = 8.22 p < 0.001; 95.7%, 0.001), lower −0.483 (−0.597, −0.368), 8.27, 0.9%, =0.423) significantly TIBC −0.612 (−0.900, −0.324), 4.16, 71%, 0.016) than survivors. This meta-analysis demonstrates ferritin, iron, banding capacity (TIBC) strongly risk, mortality COVID-19, providing strong predicting occurrence progression.

Язык: Английский

---