The Impact of Low Serum Magnesium Levels on COVID-19 Severity and Potential Therapeutic Benefits of Magnesium Supplementation: A Systematic Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

In this review, our objective was to analyze the association between serum magnesium (Mg) levels, Mg supplementation, and coronavirus disease 2019 (COVID-19) outcomes. This systematic review followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, searching major databases until February 2023. Twenty-six studies (11,363 patients) were included: 22 examining levels (8474 four investigating supplementations (2889 patients). Most indicated an lower increased COVID-19 severity, including higher mortality rates prolonged recovery periods. Critical patients demonstrated significantly compared moderate/severe cases. However, some reported conflicting findings, with hypermagnesemia also associated poor outcomes in specific patient populations. Regarding dietary intake correlated shorter hospitalization duration faster recovery. supplementation exceeding 450 mg showed potential benefits, antibody titers pregnant women reduced oxygen support requirements elderly when combined vitamins D B12. While evidence suggests a relationship status outcomes, findings are heterogeneous. Further investigation through well-designed clinical trials is required gain deeper insights into role of pathophysiology therapeutic supplementation.

Language: Английский

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Zinc(II) Complexes: Synthetic and antiviral Perspective

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114355 - 114355

Published: March 1, 2025

Language: Английский

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Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(7), P. 3138 - 3146

Published: Oct. 4, 2021

While the COVID-19 disease progresses mildly or asymptomatically in some people, its progression is severe and symptomatic others, it an issue that requires a scientific response regarding disease. The present study includes 60 people infected with COVID-19, cases were divided into following groups: asymptomatic, mild, moderate, severe. Serum Zn, Se, Cu levels of these groups analyzed by ICP-MS. All measurements patients compared those 32 healthy individuals. When patient group control group, serum Zn Se concentrations statistically low (p < 0.001) group. level decreased significantly 4 different to Although all four change was significant only mild groups. This examined concentrations, biochemical parameters severity them individuals, revealed new targets for diagnosis treatment revealing data may be important.

Language: Английский

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Can Maintaining Optimal Magnesium Balance Reduce the Disease Severity of COVID-19 Patients?

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: March 29, 2022

OPINION article Front. Endocrinol., 29 March 2022Sec. Translational Endocrinology https://doi.org/10.3389/fendo.2022.843152

Language: Английский

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Metal-induced oxidative stress and human plasma protein oxidation after SARS-CoV-2 infection

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 10, 2023

Pathogenesis of COVID-19 by SARS-CoV-2 resulted in a global pandemic and public health emergency 2020. Viral infection can induce oxidative stress through reactive oxygen species (ROS). Inflammation environmental are major sources after infection. Micronutrients such as iron, copper, zinc, manganese play various roles human tissues their imbalance blood impact immune responses against pathogens including SARS CoV-2. We hypothesized that alteration free metal ions during metal-catalyzed oxidation plays critical role towards pathogenesis analyzed convalescent hospitalized patient plasma using orthogonal analytical techniques to determine redox active concentrations, overall protein oxidation, modifications, levels via proteomics understand the consequences metal-induced proteins. Metal analysis ICP-MS showed significantly greater concentrations copper compared healthy controls. demonstrate total carbonylation, other deamidation proteins Proteomics hemoglobulin were elevated plasma. Molecular modeling concurred with potential interactions between iron binding CoV-2 surface Overall, increased metals indicate stress-induced may be consequence host cell resulting altered cellular homeostasis.

Language: Английский

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