Frontiers in Neurology, Год журнала: 2024, Номер 15
Опубликована: Дек. 3, 2024
Psychiatric disorders is a major public health problem and epilepsy contributes significantly to depression. We aimed explore the relationship between dietary patterns mental illness in patients with epilepsy.
Язык: Английский
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 10, 2024
Abstract The association between the composite dietary antioxidant index (CDAI) and hyperlipidemia remains unclear. Therefore, this study aimed to investigate relationship CDAI hyperlipidemia. data used in were obtained from National Health Nutrition Examination Survey (NHANES) dataset spanning 2005 2020. Based on 24-h recall interviews, was calculated using intake of six antioxidants. Univariate multivariate logistic regression models employed occurrence Additionally, restricted cubic spline (RCS) analysis utilized potential non-linear relationships risk final included 30,788 adults United States, among whom 25,525 (82.91%) diagnosed with A significant negative correlation observed unadjusted (Odds ratio [OR] 0.97 [95% CI 0.96, 0.98]) multi-variable adjusted (OR 0.98 0.97, 0.99]) models. When values analyzed as a categorical variable, individuals highest quartile 0.82 0.73, 0.92]) exhibited nearly one fifth decreased compared those lowest quartile. RCS revealed linear ( P for nonlinearity = 0.124). results remained consistent across subgroups except under age 60 or diabetes mellitus. There hyperlipidemia, indicating that maintaining an optimal level could effectively reduce incidence
Язык: Английский
Процитировано
5
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Авг. 17, 2024
Epilepsy is a major global health challenge, affecting approximately 50 million people across the globe and resulting in significant economic impacts on individuals society. Oxidative stress implicated pathogenesis of epilepsy, highlighting potential antioxidant-rich dietary patterns offering preventive protective benefits by mitigating oxidative stress. The Composite Dietary Antioxidant Index (CDAI) provides measure for assessing antioxidant intake, yet its link to epilepsy remains unexplored.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Дек. 5, 2024
The impact of antioxidant intake on the prognosis osteoarthritis (OA) patients remains unclear. aim this study was to investigate relationship between composite dietary index (CDAI) and all-cause mortality in OA patients. A total 35,590 participants with from National Health Nutrition Examination Survey (1999–2020) were included study. We analysed associations CDAI risk via a multivariate Cox regression model. Restricted cubic spline used dose–response mortality. also conducted stratified analyses interaction tests explore underlying effect modification. After multivariable adjustment, each one-unit increase associated 2.1% reduction Compared those low group, multivariate-adjusted hazard ratios (HRs) for high group lower [Model 1 (HR 0.648, 95% CI 0.557–0.754), Model 2 0.739, 0.627–0.871), 3 0.788, 0.661–0.941)]. observed negative nonlinear (P < 0.05). Stratification confirmed robustness results. found higher significantly These results highlight potential advantages monitoring evaluating status preventing among OA.
Язык: Английский
Процитировано
4
Frontiers in Nutrition, Год журнала: 2025, Номер 11
Опубликована: Янв. 16, 2025
Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted adverse effects high reactive oxygen species (ROS) levels in progression chronic noncommunicable also during infections. On other hand, antioxidants play a crucial role preventing oxidative or postponing cell damage via direct scavenging free radicals indirectly Keap1/Nrf2/ARE pathway, among others. Dietary can be obtained from various sources, mainly through plant-based diet, including fruits vegetables. The dietary antioxidant index (DAI) has been developed assess total intake diet. This review delineated performance DAI risk assessment different diseases. It is suggested that score prevents obesity-related diseases, diabetes mellitus, hyperuricemia, dyslipidemia, metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, negatively associated with Helicobacter pylori Human papillomavirus infection, thus reducing gastric cervical cancer. Also, osteoporosis, miscarriage, infertility, mental illnesses. However, further prospective observations clinical trials are warranted confirm application studied.
Язык: Английский
Процитировано
0
Nutrition Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1652 - 1652
Опубликована: Фев. 14, 2025
Selenoprotein S (SELENOS), one of the carrier proteins dietary selenium (Se), is a key regulator inflammation, oxidative stress, and endoplasmic reticulum (ER) all which are implicated in pathogenesis stroke. However, causality between SELENOS stroke risk remains poorly understood. This study aimed to explore association genetically determined plasma levels all-cause stroke, ischemic intracerebral hemorrhage (ICH) using two-sample Mendelian randomization (MR) approach. We analyzed data from three large-scale Genome-Wide Association Study (GWAS) meta-analyses individuals European descent. The fixed-effect inverse-variance weighted (IVW) model analysis revealed that elevated were associated with an increased ICH. Sensitivity analyses showed no evidence pleiotropy or heterogeneity, leave-one-out confirmed robustness our results. Here, we show causally linked risk. Although effect sizes modest, these findings suggest may play role pathogenesis, emphasizing need for further mechanistic functional studies. Finally, shed light on importance tailored Se intake management context prevention.
Язык: Английский
Процитировано
0
International Journal of Medical Sciences, Год журнала: 2025, Номер 22(5), С. 1184 - 1193
Опубликована: Фев. 18, 2025
Background: Increasing evidence has revealed oxidative stress as an essential risk factor in the development of rheumatoid arthritis (RA). Composite dietary antioxidant index (CDAI) is important tool for assessing capacity. However, association between CDAI and RA still unclear. Method: The data 26501 participants from NHANES database 2003-2018 cycle were collected to investigate relationship risk. Logistic regression was used examine odds ratio (OR) Restricted cubic spline (RCS) utilized test potential nonlinear relationship. Stratified analysis sensitivity also performed strengthen reliability results. Results: Multivariate logistic with full adjustment covariates showed that OR (95% confidence interval (CI)) 0.974 (0.955, 0.993). A negative correlation identified by RCS (p nonlinearity=0.046). In both subgroup analysis, this present. Conclusion: Our work suggests higher antioxidants intake correlated a lower incidence, thus providing some recommendations daily diets. Further clinical studies are acquired better validate current findings.
Язык: Английский
Процитировано
0
BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 9, 2025
Antioxidants have been investigated for their potential to prevent cardiovascular disease (CVD); however, association with mortality risk in patients CVD has not thoroughly evaluated. The aim of this study was assess the relationship between individual antioxidants and composite dietary antioxidant index (CDAI) death CVD. This included 1,395 participants from National Health Nutrition Examination Survey (2001-2010). Cox proportional hazards models were employed estimate hazard ratios (HRs) 95% confidence intervals （CIs） (including vitamins A, C, E, selenium, carotenoids zinc) CDAI levels relation all-cause death. Additionally, restricted cubic splines (RCS) utilized further investigate nonlinear relationships. Individual antioxidants, including vitamin C inversely associated both CVD-cause As CDAI, compared first tertile(T1) fully adjusted HR third tertile (T3) 0.62 (95% CI: 0.46, 0.85). For mortality, individuals T3 also exhibited a significantly reduced risk, an 0. 58 35,0.97). RCS analysis revealed linear while non-linear, inverted L-shaped observed mortality. Higher are cardiovascular-cause These findings suggest that increasing intake may serve as strategy improving outcomes population.
Язык: Английский
Процитировано
0
Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11
Опубликована: Июнь 28, 2024
Oxidative stress is a known pathogenic mechanism in cardiovascular disease (CVD), yet the association between dietary antioxidants and CVD general population remains underexplored. This study leverages data from National Health Nutrition Examination Survey (NHANES) to investigate of composite antioxidant index with US adults.
Язык: Английский
Процитировано
3
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Окт. 16, 2024
Over the past 23 years, there has been a thorough analysis of literature concerning nutritional interventions, nutrients, and feeding approaches related to stroke. Furthermore, scientific knowledge map was established, elucidating current state research, examining its development trends, offering new research viewpoints for future. This study aimed investigate global emerging trends in interventions stroke from 2000 2023 through bibliometric analysis.
Язык: Английский
Процитировано
2