Composite dietary antioxidant index is inversely and nonlinearly associated with cardiovascular disease, atherosclerotic cardiovascular disease, and cardiovascular mortality in people with dyslipidemia: evidence from NHANES 2001–2018
Frontiers in Nutrition,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 7, 2025
Dyslipidemia
is
a
major
risk
factor
for
cardiovascular
disease
(CVD)
and
atherosclerotic
CVD
(ASCVD).
The
composite
dietary
antioxidant
index
(CDAI),
an
emerging
measure
of
combined
exposure,
may
provide
insights
into
the
relationship
between
diet
CVD/ASCVD
outcomes.
We
aimed
to
explore
association
CDAI
prevalence
CVD/ASCVD,
as
well
mortality
in
individuals
with
dyslipidemia.
was
assessed
by
integrating
vitamins
A,
C,
E,
zinc,
selenium,
carotenoids.
diagnosed
according
widely
established
criteria.
Data
on
were
obtained
through
self-reports,
while
prospective
matching
participant
records
National
Death
Index
database.
Multivariate
logistic
regression
analysis
Cox
proportional
hazards
used
these
associations
calculate
odds
ratios
[OR],
hazard
[HR],
95%
confidence
intervals
[CI],
respectively.
A
total
23,126
participants
dyslipidemia
from
NHANES
2001-2018
included.
After
adjusting
potential
confounders,
inversely
associated
both
ASCVD
populations
(OR
CI
0.979
(0.964,
0.995)
0.977
(0.961,
0.993),
respectively).
Similar
observed
specific
types
CVD.
also
(HR
=
0.957,
0.939-0.976,
p
<
0.0001).
Restricted
cubic
spline
threshold
effects
analyses
indicated
that
nonlinearly
significant
occurring
only
when
CDAI≤0;
however,
>
-2.
Furthermore,
age,
sex,
drinking
found
modify
body
mass
influenced
mortality.
events
dyslipidemic
populations.
These
findings
highlight
patterns
alleviate
burden
underscore
importance
personalized
strategies.
Язык: Английский
A cross-sectional study exploring relationships between triglyceride glucose index, atherogenic index of plasma, and chronic pain: NHANES 1999–2004
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 25, 2025
Triglyceride
glucose
(TyG)
index
and
atherogenic
of
plasma
(AIP)
are
indicators
insulin
resistance.
However,
inadequate
evidence
indicates
that
the
TyG
index,
AIP,
chronic
pain
linked.
Data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
between
1999
2004
were
used.
Directed
acyclic
graphs
used
to
identify
11
potential
confounders.
The
AIP
treated
as
continuous
variables
in
multivariate
logistic
regression
models
assess
their
association
with
pain.
Furthermore,
nonlinear
relationships
these
indices
outcomes
investigated
using
restricted
cubic
spline
plots.
Subsequently,
subgroup
analyses
conducted
for
sensitive
populations.
Receiver
operating
characteristic
curves
compare
outcomes.
Ultimately,
two
sensitivity
performed.
This
study
identified
associations
16,996,513
Americans.
odds
ratio
95%
confidence
interval
(per
1
standard
deviation
increase)
was
1.17
(1.02,
1.33),
1.19
(1.07,
1.34).
According
analyses,
exposure
outcome
more
pronounced
non-diabetic
population.
performed
similarly
assessing
ROC
curves.
Additionally,
results
matched
conclusions
main
study.
Nonlinear
correlations
among
adults
United
States.
demonstrated
displayed
similar
effectiveness
predicting
risk
Язык: Английский
The Composite Dietary Antioxidant Index is Associated With Common Non-communicable Diseases: The Mediation and Joint Effects of Inflammatory Indices
Biological Research For Nursing,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Purpose:
To
evaluate
the
associations
between
composite
dietary
antioxidant
index
(CDAI)
and
common
non-communicable
diseases
(NCDs)
explore
potential
effects
of
inflammatory
indices
in
these
associations.
Methods:
We
included
20,097
adults
from
National
Health
Nutrition
Examination
Survey
2003-2018.
Multivariable
logistic
regressions
were
applied
to
CDAI
NCDs.
Mediation
analysis
was
used
role
Results:
Higher
associated
with
a
downward
trend
incidence
obesity,
cardiovascular
disease
(CVD),
chronic
respiratory
diseases,
kidney
(CKD)
(p
for
<
0.05).
The
association
CVD
influenced
by
C-reactive
protein
(CRP),
red
blood
cell
width
(RDW),
neutrophil
lymphocyte
ratio
(NLR),
mediated
proportions
3.490%,
5.173%,
2.351%,
respectively.
NLR
partially
contributed
link
CKD,
mediating
2.746%.
Additionally,
we
observed
additive
interactions
CRP
(RERI
(95%
CI):
0.282
(0.070,
0.494),
AP
0.539
(0.088,
0.991),
as
well
RDW
on
0.318
(0.124,
0.511),
0.717
(0.217,
1.218)).
There
also
appeared
be
weak
multiplicative
interaction
(p-int
=
0.049).
Conclusion:
Our
investigation
ascertained
that
related
Moreover,
played
an
important
Язык: Английский