Springer eBooks, Год журнала: 2024, Номер unknown, С. 157 - 183
Опубликована: Янв. 1, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Май 23, 2024
Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.
Язык: Английский
Процитировано
17
Ageing and Neurodegenerative Diseases, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 26, 2025
With aging, neural stem cells (NSCs) undergo age-related changes, including metabolic abnormalities, disrupted protein homeostasis, mitochondrial dysfunction, reduced genetic stability, and more notably, a diminished capacity for proliferation differentiation. These changes may contribute to the development of neurodegenerative diseases such as Alzheimer’s disease (AD) Parkinson’s (PD). In these conditions, disease-specific pathological interact with alterations NSCs, resulting in impairment neurogenesis, which further leads cognitive, mood, motor decline. Based on potential therapeutics targeting neurogenesis cell-based therapies restore functions NSCs replace degenerated neurons, aiming ameliorate functional decline diseases. While therapies, cell transplantation secretome therapy, show great treatment diseases, challenges tumorigenesis, immune rejection, extraction or storage need be addressed. A better understanding age- disease-related underlying mechanism driving benefits drawbacks therapeutic approaches provide insights novel disease-modifying interventions future
Язык: Английский
Процитировано
0
Methods in molecular biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Ophthalmology, Год журнала: 2025, Номер 45(1)
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
ACS Pharmacology & Translational Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
0
Translational Oncology, Год журнала: 2025, Номер 56, С. 102391 - 102391
Опубликована: Апрель 14, 2025
Язык: Английский
Процитировано
0
World Journal of Stem Cells, Год журнала: 2024, Номер 16(10), С. 860 - 872
Опубликована: Окт. 24, 2024
The burgeoning field of bioengineering has witnessed significant strides due to the advent stem cell models, particularly in their application advanced therapy medicinal products (ATMPs). In this review, we examine multifaceted impact these developments, emphasizing potential models enhance sophistication ATMPs and offer alternatives animal testing. Stem cell-derived tissues are promising because they can reshape preclinical landscape by providing more physiologically relevant ethically sound platforms for drug screening disease modelling. We also discuss critical challenges reproducibility accuracy measurements ensure integrity utility research application. Moreover, review highlights imperative align with regulatory standards, ensuring using cells translates into safe effective clinical therapies. With approval serving as a gateway adoption, collaborative efforts between scientists regulators vital progression applications from bench bedside. advocate balanced approach that nurtures innovation within framework rigorous validation compliance, cell-base solutions maximized promote public trust patient health ATMPs.
Язык: Английский
Процитировано
3
Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)
Опубликована: Апрель 7, 2025
Neurodegeneration is one of the leading factor for death globally, affecting millions people. Developing animal models are critical to understand biological processes and comprehend pathological hallmarks neurodegenerative diseases. For decades, many have served as excellent tools determine disease progression, develop diagnostic methods design novel therapies against distinct pathologies. Here, we provide a comprehensive overview both, mammalian non-mammalian models, with focus on three most common aggressive disorders: Alzheimer's disease, Parkinson's Spinocerebellar ataxia-1. We highlight various approaches including transgene, gene transfer, chemically-induced used models. In particular, discuss applications both contributions in research neurodegeneration. It exciting learn roles pathomechanisms, identifying biomarkers hence devising interventions treat neuropathological conditions.
Язык: Английский
Процитировано
0
Translational Research in Anatomy, Год журнала: 2025, Номер unknown, С. 100404 - 100404
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Animal Models and Experimental Medicine, Год журнала: 2024, Номер unknown
Опубликована: Окт. 7, 2024
Abstract Animal models have been a crucial tool in neuroscience research for decades, providing insights into the biomedical and evolutionary mechanisms of nervous system, disease, behavior. However, their use has raised concerns on several ethical, clinical, scientific considerations. The welfare animals 3R principles (replacement, reduction, refinement) are focus ethical concerns, targeting importance reducing stress suffering these models. Several laws guidelines applied developed to protect animal rights during experimenting. Concurrently, clinic fields, discussions relevance model findings human organisms increased. Latest data suggest that considerable amount time results not translatable humans, costing money. Alternative methods, such as vitro (cell culture, microscopy, organoids, micro physiological systems) techniques silico (computational) modeling, emerged potential replacements models, more accurate minimized cost. By adopting alternative methods promoting considerations practices, we can achieve goals while upholding our responsibility both humans other animals. Our goal is present thorough review used from biomedical, evolutionary, perspectives. novelty this lies integrating diverse points views provide an understanding advantages disadvantages discussing methods.
Язык: Английский
Процитировано
2