Recognizing Dupilumab‐Associated Head and Neck Dermatitis in Skin of Color: A Case Series
Clinical Case Reports,
Год журнала:
2025,
Номер
13(3)
Опубликована: Фев. 26, 2025
ABSTRACT
Dupilumab‐associated
head
and
neck
dermatitis
(HND)
is
a
rare
often
underrecognized
condition,
especially
in
patients
with
skin
of
color.
It
can
vary
from
subtle
to
severe
presentations,
violaceous
hues
seborrheic
distribution
after
dupilumab
initiation.
Early
recognition
management
are
crucial
prevent
treatment
discontinuation.
Язык: Английский
A Case of Cutaneous Fungal Infection Following the Administration of Dupilumab
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
condition
with
multifactorial
etiology.
Herein,
we
report
case
of
patient
AD
undergoing
long-term
topical
treatments
who
developed
dermatophyte
infection
following
the
administration
dupilumab.
Dupilumab
known
to
enhance
barrier
function
and
induce
changes
in
microbiome.
Notably,
head
neck
caused
by
overgrowth
Malassezia
species
due
dupilumab
has
been
widely
discussed.
This
phenomenon
thought
result
from
suppression
T
helper
(Th)2
cytokines
dupilumab,
leading
decrease
proportion
Staphylococcus
aureus
relative
increase
fungal
populations.
Additionally,
feedback
activation
Th17
may
trigger
excessive
inflammation
against
fungi,
contributing
infections.
IL-13
plays
critical
roles
colony
formation,
tralokinumab,
an
inhibitor,
shown
potential
efficacy
treating
this
dermatitis.
While
relationship
between
microbiome
biologics
like
lebrikizumab
nemolizumab
remains
unexplored,
investigating
differential
effects
these
therapies
on
cutaneous
could
provide
deeper
insights
into
not
only
unique
characteristics
each
biologic
agent
but
also
Th2
such
as
IL-4,
IL-13,
IL-31
pathophysiology
AD.
The
present
underscores
importance
comprehensive
therapeutic
approach
for
that
accounts
dynamics
adapts
evolving
throughout
course
treatment.
Язык: Английский
Recognizing secondary infection in patients with atopic dermatitis: Head & neck atopic dermatitis
Meditsinskiy sovet = Medical Council,
Год журнала:
2025,
Номер
2, С. 42 - 48
Опубликована: Март 30, 2025
Atopic
dermatitis
is
a
hereditary
chronic
skin
disease
characterized
by
severe
itching,
recurrent
course
and
association
with
other
diseases
of
atopic
nature,
as
well
numerous
complications,
which
include
the
addition
secondary
infection.
Head
neck
(HNAD)
special
phenotype
that
occurs
in
adolescents
adults.
A
characteristic
feature
HNAD
lesion
areas
rich
sebaceous
glands
(face,
neck,
upper
third
chest
back),
associated
active
participation
Malassezia
fungi
pathogenesis
dermatosis.
The
multifactorial
HNAD,
often
persistent
course,
impossibility
complete
elimination
provoking
factor,
bacterial
infection
against
background
necessitate
comprehensive
approach
to
treatment
this
condition
use
combination
drugs
containing
glucocorticosteroid,
an
antimycotic
antibiotic
relieve
exacerbations.
article
examines
etiology,
mechanisms
development
clinical
features,
modern
methods
therapy,
practical
application
demonstrated
example:
patient,
19
years
old,
complaining
itchy,
flaky
rashes
face
area,
existing
for
3
weeks.
Based
on
picture,
diagnosis
was
made:
neck.
Given
multifaceted
cause
condition,
namely
both
pronounced
immune
response
AD,
colonization
fungi,
open
“gates”
form
erosions,
prescription
topical
glucocorticosteroid
pathogenetically
justified.
Язык: Английский
A multidimensional analysis of prognostic factors in atopic dermatitis
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 17, 2025
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
condition
with
high
prevalence
worldwide
and
multifaceted
pathogenesis.
In
general,
patients
moderate
to
severe
AD
often
experience
relapse
after
discontinuing
treatment.
Therefore,
understand
the
possible
factors
of
look
for
biological
markers
that
predict
or
poor
prognosis
will
be
helpful
clinical
Mutations
in
genes
such
as
FLG,
SPINK5,
STAT,
KIF3A,
claudin-1,
Ovol1,
HLA-DRB1
offer
new
insights
into
genetic
basis
AD.
Routine
may
help
improve
patient
lifestyle,
highlight
importance
environmental
influences
(including
psychological
stress),
support
clinicians
optimizing
anti-infective
treatment
strategies.
The
axis
(CD30–CD30L
axis,
IL-9-IL-18
axis)
provides
pathways
target
future
therapies.
Low
NKG2D
expression
have
adverse
effects
on
prognosis.
Prognostic
biomarkers
can
play
an
important
role
monitoring,
disease
progression
recurrence,
provide
possibility
more
personalized
Язык: Английский