Recognizing Dupilumab‐Associated Head and Neck Dermatitis in Skin of Color: A Case Series

Clinical Case Reports, Journal Year: 2025, Volume and Issue: 13(3)

Published: Feb. 26, 2025

ABSTRACT Dupilumab‐associated head and neck dermatitis (HND) is a rare often underrecognized condition, especially in patients with skin of color. It can vary from subtle to severe presentations, violaceous hues seborrheic distribution after dupilumab initiation. Early recognition management are crucial prevent treatment discontinuation.

Language: Английский

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A Case of Cutaneous Fungal Infection Following the Administration of Dupilumab

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin condition with multifactorial etiology. Herein, we report case of patient AD undergoing long-term topical treatments who developed dermatophyte infection following the administration dupilumab. Dupilumab known to enhance barrier function and induce changes in microbiome. Notably, head neck caused by overgrowth Malassezia species due dupilumab has been widely discussed. This phenomenon thought result from suppression T helper (Th)2 cytokines dupilumab, leading decrease proportion Staphylococcus aureus relative increase fungal populations. Additionally, feedback activation Th17 may trigger excessive inflammation against fungi, contributing infections. IL-13 plays critical roles colony formation, tralokinumab, an inhibitor, shown potential efficacy treating this dermatitis. While relationship between microbiome biologics like lebrikizumab nemolizumab remains unexplored, investigating differential effects these therapies on cutaneous could provide deeper insights into not only unique characteristics each biologic agent but also Th2 such as IL-4, IL-13, IL-31 pathophysiology AD. The present underscores importance comprehensive therapeutic approach for that accounts dynamics adapts evolving throughout course treatment.

Language: Английский

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Recognizing secondary infection in patients with atopic dermatitis: Head & neck atopic dermatitis

Meditsinskiy sovet = Medical Council, Journal Year: 2025, Volume and Issue: 2, P. 42 - 48

Published: March 30, 2025

Atopic dermatitis is a hereditary chronic skin disease characterized by severe itching, recurrent course and association with other diseases of atopic nature, as well numerous complications, which include the addition secondary infection. Head neck (HNAD) special phenotype that occurs in adolescents adults. A characteristic feature HNAD lesion areas rich sebaceous glands (face, neck, upper third chest back), associated active participation Malassezia fungi pathogenesis dermatosis. The multifactorial HNAD, often persistent course, impossibility complete elimination provoking factor, bacterial infection against background necessitate comprehensive approach to treatment this condition use combination drugs containing glucocorticosteroid, an antimycotic antibiotic relieve exacerbations. article examines etiology, mechanisms development clinical features, modern methods therapy, practical application demonstrated example: patient, 19 years old, complaining itchy, flaky rashes face area, existing for 3 weeks. Based on picture, diagnosis was made: neck. Given multifaceted cause condition, namely both pronounced immune response AD, colonization fungi, open “gates” form erosions, prescription topical glucocorticosteroid pathogenetically justified.

Language: Английский

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A multidimensional analysis of prognostic factors in atopic dermatitis

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 17, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin condition with high prevalence worldwide and multifaceted pathogenesis. In general, patients moderate to severe AD often experience relapse after discontinuing treatment. Therefore, understand the possible factors of look for biological markers that predict or poor prognosis will be helpful clinical Mutations in genes such as FLG, SPINK5, STAT, KIF3A, claudin-1, Ovol1, HLA-DRB1 offer new insights into genetic basis AD. Routine may help improve patient lifestyle, highlight importance environmental influences (including psychological stress), support clinicians optimizing anti-infective treatment strategies. The axis (CD30-CD30L axis, IL-9-IL-18 axis) provides pathways target future therapies. Low NKG2D expression have adverse effects on prognosis. Prognostic biomarkers can play an important role monitoring, disease progression recurrence, provide possibility more personalized

Language: Английский

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