Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Май 11, 2022
The
gut
microbiota
has
been
associated
with
primary
Sjogren’s
syndrome
(pSS),
yet
the
biological
implications
of
these
associations
are
often
elusive.
We
analyzed
fecal
through
16S
rRNA
gene
amplification
and
sequencing
in
30
patients
pSS
20
healthy
controls
(HCs);
At
same
time,
metabolome
was
characterized
by
ultrahigh-performance
liquid
chromatography–mass
spectrometry.
In
addition,
correlation
analyses
data
were
performed
to
identify
meaningful
associations.
found
that
composition
significantly
different
from
HCs.
is
increased
abundances
proinflammatory
microbes,
especially
Escherichia-Shigella
,
decreased
anti-inflammatory
microbes.
Concerning
metabolome,
a
multivariate
model
33
metabolites
efficiently
distinguished
cases
controls.
Through
KEGG
enrichment
analysis,
we
mainly
involved
amino
acid
metabolism
lipid
metabolism.
analysis
indicated
there
certain
correlations
between
patients.
an
abundance
be
correlated
high
levels
four
(aflatoxin
M1,
glycocholic
acid,
L-histidine
phenylglyoxylic
acid).
Our
research
suggests
patients,
specific
combination
changes
metabolic
states.
factor
related
dysbiosis,
which
may
promote
intestinal
damage
affect
Life,
Год журнала:
2024,
Номер
14(5), С. 559 - 559
Опубликована: Апрель 26, 2024
The
gastrointestinal
tract
is
home
to
trillions
of
diverse
microorganisms
collectively
known
as
the
gut
microbiota,
which
play
a
pivotal
role
in
breaking
down
undigested
foods,
such
dietary
fibers.
Through
fermentation
these
food
components,
short-chain
fatty
acids
(SCFAs)
acetate,
propionate,
and
butyrate
are
produced,
offering
numerous
health
benefits
host.
production
absorption
SCFAs
occur
through
various
mechanisms
within
human
intestine,
contingent
upon
types
fibers
reaching
specific
engaged
fermentation.
Medical
literature
extensively
documents
supplementation
SCFAs,
particularly
butyrate,
treatment
gastrointestinal,
metabolic,
cardiovascular,
gut-brain-related
disorders.
This
review
seeks
provide
an
overview
dynamics
involved
gut.
Additionally,
it
will
focus
on
roles
promoting
metabolic
health,
well
their
current
therapeutic
implications.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114620 - 114620
Опубликована: Март 31, 2023
There
is
emerging
evidence
that
microbiota
and
its
metabolites
play
an
important
role
in
helath
diseases.
In
this
regard,
gut
has
been
found
as
a
crucial
component
influences
immune
responses
well
immune-related
disorders
such
autoimmune
Gut
bacterial
dysbiosis
shown
to
cause
disease
altered
metabolite
synthesis,
leading
immunological
metabolic
dysregulation.
Of
note,
the
produce
short-chain
fatty
acids
(SCFAs)
acetate,
butyrate,
propionate,
remodeling
these
linked
pathophysiology
of
number
type
1
diabetes,
multiple
sclerosis,
inflammatory
bowel
disease,
rheumatoid
arthritis,
celiac
systemic
lupus
erythematosus.
review,
we
will
address
most
recent
findings
from
noteworthy
studies
investigating
impact
SCFAs
on
various
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Янв. 8, 2024
Tryptophan
(TRP)
contributes
to
individual
immune
homeostasis
and
good
condition
via
three
complex
metabolism
pathways
(5-hydroxytryptamine
(5-HT),
kynurenine
(KP),
gut
microbiota
pathway).
Indole
propionic
acid
(IPA),
one
of
the
TRP
derivatives
pathway,
has
raised
more
attention
because
its
impact
on
metabolic
disorders.
Here,
we
retrospect
increasing
evidence
that
metabolites/IPA
derived
from
proteolysis
host
health
disease.
IPA
can
activate
system
through
aryl
hydrocarbon
receptor
(AHR)
and/or
Pregnane
X
(PXR)
as
a
vital
mediator
among
diet-caused
microbe
cross-talk.
Different
levels
in
systemic
circulation
predict
risk
NAFLD,
T2DM,
CVD.
is
suggested
alleviate
cognitive
impairment
oxidative
damage,
reduce
inflammation,
inhibit
lipid
accumulation
attenuate
symptoms
putatively
enhance
intestinal
epithelial
barrier,
maintain
homeostasis.
Now,
provide
general
description
relationships
between
various
physiological
pathological
processes,
which
support
an
opportunity
for
diet
intervention
diseases.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Diabetes
mellitus
represents
a
significant
global
health
problem.
The
number
of
people
suffering
from
this
metabolic
disease
is
constantly
rising
and
although
the
incidence
heterogeneous
depending
on
region,
country,
economic
situation,
lifestyle,
diet
level
medical
care,
it
increasing
worldwide,
especially
among
youths
children,
mainly
due
to
lifestyle
environmental
changes.
pathogenesis
two
most
common
subtypes
diabetes
mellitus,
type
1
(T1DM)
2
(T2DM),
substantially
different,
so
each
form
characterized
by
different
causation,
etiology,
pathophysiology,
presentation,
treatment.
Research
in
recent
decades
increasingly
indicates
potential
role
gut
microbiome
initiation,
development,
progression
disease.
Intestinal
microbes
their
fermentation
products
have
an
important
impact
host
metabolism,
immune
system,
nutrient
digestion
absorption,
barrier
integrity
protection
against
pathogens.
This
review
summarizes
current
evidence
changes
microbial
populations
both
types
mellitus.
Attention
focused
abundance
specific
bacterial
groups
at
taxonomic
levels
humans,
shift
also
assessed
relation
geographic
location,
age,
antidiabetic
drug.
causal
relationship
between
bacteria
still
unclear,
future
studies
applying
new
methodological
approaches
broader
range
microorganisms
inhabiting
digestive
tract
are
urgently
needed.
would
not
only
provide
better
understanding
disease,
but
use
beneficial
species
probiotics
for
treatment
diabetes.
Diabetes Research and Clinical Practice,
Год журнала:
2020,
Номер
172, С. 108645 - 108645
Опубликована: Дек. 24, 2020
The
microbiome
is
greatly
significant
for
immune
system
development
and
homeostasis.
Dysbiosis
in
gut
microbial
composition
function
linked
to
responses
the
of
metabolic
diseases,
including
diabetes
mellitus
(DM).
However,
skin
changes
diabetic
patients
their
role
DM
are
poorly
elucidated.
In
this
review,
we
summarize
recent
findings
about
association
between
microbiota
DM,
highlighting
roles
proinflammatory
status
DM.
Moreover,
although
there
evidence
that
connection
causes
same
activated
innate
response,
additional
studies
needed
explore
mechanism.
These
might
inform
future
prevention,
diagnosis
treatment.
Frontiers in Endocrinology,
Год журнала:
2021,
Номер
12
Опубликована: Окт. 19, 2021
Metagenomics
studies
have
shown
that
type
2
diabetes
(T2D)
is
associated
with
an
altered
gut
microbiota.
Whereas
different
microbiota
patterns
been
observed
in
independent
human
cohorts,
reduction
of
butyrate-producing
bacteria
has
consistently
found
individuals
T2D,
as
well
those
prediabetes.
Butyrate
produced
the
large
intestine
by
microbial
fermentations,
particularly
dietary
fiber,
and
serves
primary
fuel
for
colonocytes.
It
also
acts
histone
deacetylase
inhibitor
ligand
to
G-protein
coupled
receptors,
affecting
cellular
signaling
target
cells,
such
enteroendocrine
cells.
Therefore,
butyrate
become
attractive
drug
treatment
strategies
devised
increase
its
intestinal
levels,
example
supplementation
or
through
fecal
transplant
(FMT).
In
this
review,
we
provide
overview
current
literature
indicating
these
yielded
encouraging
results
short-term
benefits
humans,
but
long-term
improvements
glycemic
control
not
reported
so
far.
Further
are
required
find
effective
approaches
restore
levels
gut,
investigate
their
impact
on
glucose
regulation
T2D.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Авг. 12, 2021
Type
2
diabetes
mellitus
(T2DM)
is
a
complex
disorder
comprehensively
influenced
by
genetic
and
environmental
risk,
research
increasingly
has
indicated
the
role
of
microbial
dysbiosis
in
T2DM
pathogenesis.
However,
studies
comparing
microbiome
characteristics
between
healthy
controls
have
reported
inconsistent
results.
To
further
identify
describe
intestinal
flora
patients,
we
performed
systematic
review
meta-analysis
stool
profiles
to
discern
explore
heterogeneity
among
7
(600
cases,
543
controls,
1143
samples
total).
Using
random
effects
model
fixed
model,
observed
significant
differences
beta
diversity,
but
not
alpha
individuals
with
controls.
We
identified
various
operational
taxonomic
unit
(OTUs)
bacterial
genera
odds
ratios
for
T2DM.
The
signatures
derived
from
single
study
stepwise
feature
selection
could
be
applied
other
studies.
By
training
on
multiple
studies,
improved
detection
accuracy
disease
specificity
also
discuss
relationship
T2DM-enriched
or
T2DM-depleted
probiotics
provide
new
ideas
prevention
improvement.
