Identification of stem cell-related gene signature and integrative analyses in patients with lower-grade gliomas DOI Creative Commons
Longyang Jiang, Jun Zhu, Xuping Yang

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Сен. 15, 2023

Abstract Background: Cancer stem cell genes were proven to be associated with the prognosis of multiple cancers. Nevertheless, and role division-related in lower-grade glioma (LGG) remains unclear. Objective: This study constructs a reliable risk model for predicting LGG patients. Methods: The mutation data, FPKM data corresponding clinical information 511 patients downloaded from TCGA database. We carried out LASSO regression analysis multivariate cox build gene model. Kaplan-Meier survival was used evaluate overall (OS) rate ROC curve assesses its power across entire set. score validated Chinese Glioma Genome Atlas (CGGA). employed univariate independent prognostic multifactor determine whether scores could as factors predict clinicopathological characteristics LGG. A nomogram constructed In addition, we analyzed relationship between high low groups immune infiltration drug sensitivity. Results: 11 selected (EV12B, ING2, MLLT3, NCOA3, NOTCH1, PRDM15, SFRP2, SMYD5, THOC2, TIAL1 WNT7A) construct model, which CGGA. accompanied by calibration curves presented 1-, 3-, 5-year low-risk group had longer than those high-risk group. might serveas diagnostic biomarkers related Drug sensitivity showed Bortrezomib (p<0.0001), Etoposide Tamoxifen Temozolomide (p<0.0001) more sensitive Conclusion: Our built consisting may new biomarker These preliminary findings provide some useful values future studies.

Язык: Английский

First genome-wide association study and genomic prediction for growth traits in spotted sea bass (Lateolabrax maculatus) using whole-genome resequencing DOI
Chong Zhang, Haishen Wen,

Yonghang Zhang

и другие.

Aquaculture, Год журнала: 2022, Номер 566, С. 739194 - 739194

Опубликована: Дек. 22, 2022

Язык: Английский

Процитировано

26
The role of CircRNA/miRNA/mRNA axis in breast cancer drug resistance DOI Creative Commons
Mohammad H. Ghazimoradi, Sadegh Babashah

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Сен. 5, 2022

Multidrug resistance is one of the major obstacles in treatment cancers. This undesirable feature increases mortality rate cancers, including breast cancer. Circular RNA (CircRNA)/microRNA (miRNA)/messenger (mRNA) important axes with roles promotion and heterogeneous pathway includes mRNA oncogenes tumor suppressors, which are controlled by miRNAs CircRNAs. Unfortunately, this network could be easily deregulated, resulting drug development. Therefore, understanding these dysregulations may thus help to identify effective therapeutic targets. On basis, we try review latest findings field, us better comprehend significant axis

Язык: Английский

Процитировано

24
Genomic Characterization of Crossbred-Driven Adaptation in the Endangered Yangba Cattle of China DOI Creative Commons

Bao Cai,

Yandong Kang,

Ziqiang Ding

и другие.

Animals, Год журнала: 2025, Номер 15(7), С. 1065 - 1065

Опубликована: Апрель 6, 2025

This study unveils the unique origins, evolution, and genetic variations of Yangba cattle, an endangered breed in China, through a comparative genomic analysis involving 202 individuals from 21 domestic international breeds. Genetic component revealed that cattle comprise four ancestral lineages: Eurasian taurine (18%), East Asian (26%), Chinese indicine (39%), Indian (17%). Their high diversity low inbreeding coefficient set them apart significantly mainstream commercial Gene introgression indicated influx material has enhanced cattle's adaptability to environmental stress, while endowed with advantages muscle development tissue repair. A genome-wide selection scan identified strong positive signals for genes such as ABCC2, which is involved immune regulation, NCOA3, plays role growth cattle. systematically elucidates, first time, composite composition mechanisms adaptive evolution These findings offer critical insights into conservation sustainable utilization resources underscore importance implementing effective breeding programs.

Язык: Английский

Процитировано

0
PCAF acetylates AIB1 to form a transcriptional coactivator complex to promote glycolysis in endometrial cancer DOI Creative Commons
Di Wu, Mingxia Li, Mingyang Wang

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Сен. 5, 2024

Despite rapid advances in molecular biology, personalized therapy remains a clinical challenge for endometrial cancer due to its complex and heterogeneous tumor microenvironment.Based on findings, AIB1 is marker molecule poor prognosis may serve as potential therapeutic target. Moreover, it well known that aerobic glycolysis plays an important role tumour energy metabolism. It has been previously reported various hormone-related studies affects promotes development. However, the link between estrogen-dependent unclear.

Язык: Английский

Процитировано

2
ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma DOI
Rachel Han, Josephine K. Dermawan, Elizabeth G. Demicco

и другие.

Genes Chromosomes and Cancer, Год журнала: 2022, Номер 61(11), С. 645 - 652

Опубликована: Май 6, 2022

Abstract Spindle cell rhabdomyosarcoma represents a rare neoplasm characterized by monomorphic spindle cells with fascicular architecture and variable skeletal muscle differentiation. Following incidental identification of ZFP64::NCOA3 gene fusion in an unclassified sarcoma resembling adult‐type fibrosarcoma, we performed retrospective archival review identified four additional cases similar histology identical fusion. All tumors arose adult males (28–71 years). The neoplasms were found the deep soft tissues, two gluteal, one each thigh, abdominal wall, chest wall. Morphologically, distinctive herringbone pattern collagenous to myxoid stroma. nuclei relatively mitotic activity. Three had immunoreactivity for MyoD1, contained expression desmin smooth actin. tested myogenin, CD34, S100, pankeratin, epithelial membrane antigen negative. Targeted RNA sequencing revealed product all five tumors. patients developed distant metastases, ultimately succumbed their disease within 2 years initial diagnosis. This study suggests fusions define novel subtype morphology aggressive clinical behavior. potential morphologic immunohistochemical overlap several other types underscores value molecular testing as diagnostic adjunct ensure accurate classification management these neoplasms.

Язык: Английский

Процитировано

6
Bone marrow mesenchymal stem cells‐derived exosomes mediate nuclear receptor coactivator‐3 expression in osteoblasts by delivering miR‐532‐5p to influence osteonecrosis of the femoral head development DOI
Xiaoyong Lan, Haiping Ma,

Yipin Xiong

и другие.

Cell Biology International, Год журнала: 2022, Номер 46(12), С. 2185 - 2197

Опубликована: Сен. 18, 2022

Exosomes (Exo) originated from bone marrow mesenchymal stem cells (BMSCs) have therapeutic impacts on osteonecrosis of the femoral head (ONFH), and microRNA (miR)-532-5p has been confirmed to participate in ONFH progression. In research, it was figured out whether BMSCs-Exo could relieve by delivering miR-532-5p. MG-63 were treated with DEX construct an cell model vitro. The effects Exo miR-532-5p viability, lactate dehydrogenase (LDH) content, apoptosis BMSCs detected. rat established, effect pathological damage rats evaluated. Changes nuclear receptor coactivator-3 (NCOA3) apoptotic proteins assessed western blot. relationship between NCOA3 verified dual luciferase reporter experiments. elevated vivo vitro ONFH-models, while expression reduced. Overexpression aggravated toxicity osteoblasts, decreased promoted apoptosis. Knockdown made further attenuate toxic osteoblasts inhibited protective miR-532-5p-delivering reversed silencing. addition, experiments also that knockdown enhanced rats. This study demonstrates inhibits osteoblast viability promote targeting NCOA3, thereby aggravating development.

Язык: Английский

Процитировано

4
Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma DOI Creative Commons

Imani Bijou,

Yang Liu, Dong Lu

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(4), С. e0289902 - e0289902

Опубликована: Апрель 29, 2024

Mantle cell lymphoma (MCL) has a poor prognosis and high relapse rates despite current therapies, necessitating novel treatment regimens. Inhibition of SRC-3 show effectiveness in vivo vitro other B lymphomas. Additionally, previous studies have shown that is highly expressed the lymph nodes non-Hodgkin’s patients, suggesting may play role progression lymphoma. This study aimed to investigate inhibitors, SI-10 SI-12, mantle The cytotoxic effects SI-12 were evaluated demonstrated dose-dependent cytotoxicity panel MCL lines. efficacy was confirmed two ibrutinib-resistant models: an immunocompetent disseminated A20 mouse model B-cell human PDX MCL. Notably, also resulted significant extension survival with low toxicity both murine models. We investigated as anti-lymphoma compound via inhibition activity. These findings indicate targeting should be combination clinical therapeutics strategy expand therapeutic index improve outcomes.

Язык: Английский

Процитировано

0
Evaluation of the diagnostic utility of NCOA3, Maspin and VHL protein expression in pancreatic ductal adenocarcinoma: An immunohistochemical study DOI
Noha Elkady,

Walaa Elgendy,

Mohamed T. Badr

и другие.

Annals of Diagnostic Pathology, Год журнала: 2024, Номер 73, С. 152356 - 152356

Опубликована: Июнь 18, 2024

Язык: Английский

Процитировано

0
Pathological discrimination between luteinized thecoma associated with sclerosing peritonitis and thecoma DOI Creative Commons
Jia Liu, Jia Wei,

Yiqun Yang

и другие.

Medicine, Год журнала: 2023, Номер 102(23), С. e33911 - e33911

Опубликована: Июнь 9, 2023

Similarities between luteinized thecoma associated with sclerosing peritonitis (LTSP) and thecoma, cause difficulty in clinical differential diagnoses. To improve the situation, we selected 10 specified molecular pathological markers that are frequently used pathology of ovarian sex cord-stromal tumors to determine whether they exert a discriminatory effect.Applying immunohistochemistry, analyzed expression alpha-1,6-mannosylglycoprotein 6-beta-n-acetylglucosaminyltransferase B (MGAT5B), nuclear receptor coactivator 3 (NCOA3), proliferation marker protein Ki-67 (MKI67), estrogen receptor, progesterone Vimentin, tyrosine-protein kinase erbB-2, Catenin beta-1 (β-Catenin), CD99 antigen (CD99) Wilms tumor (WT1) 102 cases diseases containing 11 LTSP 91 thecoma. Whole-exome sequencing fluorescence situ hybridization were examine MGAT5B-NCOA3 fusion gene LTSP. Statistical analysis was performed using t test, one-way variance post hoc test.Six significant verified for discrimination 4 upregulating indicators MGAT5B, NCOA3, MKI67, β-Catenin, 2 downregulating WT1 cells. In addition, identified first time significantly rich compared thecoma.We 6 CD99, LTSP; this work will help clinicians discriminate medical conditions treat patients accurately.

Язык: Английский

Процитировано

1
Phytochemicals as estrogen receptor modulators?—a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment DOI Open Access
Claudia Beatriz Hereñú, Rosana Crespo

Translational Cancer Research, Год журнала: 2023, Номер 12(12), С. 3249 - 3254

Опубликована: Дек. 1, 2023

Язык: Английский

Процитировано

1