The Interplay of Aging, Sleep Dysregulation, and Mitochondrial Dysfunction in Metabolic and Neurodegenerative Diseases

Pharmacological Research, Год журнала: 2025, Номер 212, С. 107614 - 107614

Опубликована: Янв. 18, 2025

Язык: Английский

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Mitochondria Express Functional Signaling Ligand-Binding Receptors that Regulate their Biological Responses – the Novel Role of Mitochondria as Stress-Response Sentinels

Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Evidence accumulated mitochondria, as the "powerplants of cell," express several functional receptors for external ligands that modify their function and regulate cell biology. This review sheds new light on role these organelles in sensing stimuli to facilitate energy production cellular needs. is possible because mitochondria some membranes are responsible autonomous responses. not surprising given widely accepted hypothesis intracellular originated from prokaryotic ancestors fused with eukaryotic cells during early evolution. It has been reported estrogen, androgen, glucocorticoid, 5-hydroxytryptamine, melatonin, cannabinoid receptors. What intriguing recent evidence showing could also be directly regulated by active mediators complement (complosome) intrinsic purinergic signaling. Accordingly, they cleavage fragments (C5a C3a) well adenosine triphosphate (ATP), which, besides its crucial transferring cells, an important signaling molecule interacting P2X7 receptor expressed only surface but membrane. Based this, complosome emerge cooperating regulators reactive oxygen species (ROS) release activators pattern recognition Nlrp3 inflammasome. activation within beneficial "hormetic zone response" regulates metabolism, proliferation, migration, adaptation surrounding challenges microenvironment a favorable way.

Язык: Английский

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Exploring the bidirectional relationship between chronic kidney disease and obstructive sleep apnea

SLEEP, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Mitochondrial dysfunction as the missing link between circadian syndrome and dementia

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100125 - 100125

Опубликована: Март 1, 2025

Язык: Английский

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The immune response and autophagy of Macrobrachium rosenbergii against Aeromonas veronii infection

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Год журнала: 2025, Номер unknown, С. 101488 - 101488

Опубликована: Март 1, 2025

Язык: Английский

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Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and Neuroendocrinopathy

Journal of Molecular Neuroscience, Год журнала: 2024, Номер 74(4)

Опубликована: Ноя. 8, 2024

Язык: Английский

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